1RXT

Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D	d1rxtd1	Alpha and beta proteins (a+b)	Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	N-myristoyl transferase, NMT	N-myristoyl transferase, NMT	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1rxta1	Alpha and beta proteins (a+b)	Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	N-myristoyl transferase, NMT	N-myristoyl transferase, NMT	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1rxtb1	Alpha and beta proteins (a+b)	Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	N-myristoyl transferase, NMT	N-myristoyl transferase, NMT	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1rxtc1	Alpha and beta proteins (a+b)	Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	N-myristoyl transferase, NMT	N-myristoyl transferase, NMT	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8032315	3000403	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8032317	3000403	SCOP2B (2022-06-29)
A	SCOP2 Family	N-myristoyl transferase NMT	8019935	4001819	SCOP2 (2022-06-29)
A	SCOP2 Family	N-myristoyl transferase NMT	8019937	4001819	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Acyl-CoA N-acyltransferases (Nat)	8032315	3000403	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Acyl-CoA N-acyltransferases (Nat)	8032317	3000403	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8032317	3000403	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8032315	3000403	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8032315	3000403	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8032317	3000403	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	PF01233	e1rxtD1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: PF01233	ECOD (1.6)
D	PF02799	e1rxtD2	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: PF02799	ECOD (1.6)
A	PF01233	e1rxtA1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: PF01233	ECOD (1.6)
A	PF02799	e1rxtA2	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: PF02799	ECOD (1.6)
B	PF01233	e1rxtB1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: PF01233	ECOD (1.6)
B	PF02799	e1rxtB2	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: PF02799	ECOD (1.6)
C	PF01233	e1rxtC4	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: PF01233	ECOD (1.6)
C	PF02799	e1rxtC3	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: PF02799	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)
A	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)
B	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)
C	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF01233	Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain (NMT)	Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain	The N and C-terminal domains of NMT are structurally similar, each adopting an acyl-CoA N-acyltransferase-like fold.	Domain
A, B, C, D	PF02799	Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain (NMT_C)	Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain	The N and C-terminal domains of NMT are structurally similar, each adopting an acyl-CoA N-acyltransferase-like fold.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Glycylpeptide N-tetradecanoyltransferase 1	myristoyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity catalytic activity, acting on a protein peptidyl-lysine N6-myristoyltransferase activity glycylpeptide N-tetradecanoyltransferase activity N-acyltransferase activity	cellular biosynthetic process lipoprotein biosynthetic process lipoprotein metabolic process organonitrogen compound biosynthetic process N-terminal protein lipidation N-terminal protein myristoylation protein acylation protein lipidation organic substance metabolic process protein myristoylation peptidyl-amino acid modification organic substance biosynthetic process N-terminal peptidyl-glycine N-myristoylation protein metabolic process cellular biosynthetic process lipoprotein biosynthetic process lipoprotein metabolic process organonitrogen compound biosynthetic process N-terminal protein lipidation N-terminal protein myristoylation protein acylation protein lipidation organic substance metabolic process protein myristoylation peptidyl-amino acid modification organic substance biosynthetic process N-terminal peptidyl-glycine N-myristoylation protein metabolic process protein modification process organonitrogen compound metabolic process cellular metabolic process primary metabolic process macromolecule biosynthetic process biosynthetic process N-terminal protein amino acid modification peptidyl-glycine modification macromolecule modification metabolic process cellular process macromolecule metabolic process cellular ketone metabolic process small molecule metabolic process protein localization localization cellular localization cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane cellular response to stimulus response to light stimulus regulation of cellular process response to stimulus regulation of response to external stimulus signaling regulation of opsin-mediated signaling pathway regulation of signal transduction detection of abiotic stimulus cellular response to environmental stimulus cell communication cellular response to light stimulus signal transduction regulation of G protein-coupled receptor signaling pathway rhodopsin mediated signaling pathway detection of light stimulus phototransduction detection of external stimulus regulation of biological process regulation of signaling biological regulation detection of visible light response to external stimulus cellular response to radiation detection of stimulus regulation of response to stimulus regulation of cell communication response to radiation response to abiotic stimulus G protein-coupled receptor signaling pathway cellular response to abiotic stimulus phototransduction, visible light developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR022676	Glycylpeptide N-tetradecanoyltransferase, N-terminal	Domain
A, B, C, D	IPR016181	Acyl-CoA N-acyltransferase	Homologous Superfamily
A, B, C, D	IPR022677	Glycylpeptide N-tetradecanoyltransferase, C-terminal	Domain
A, B, C, D	IPR000903	Glycylpeptide N-tetradecanoyltransferase	Family
A, B, C, D	IPR022678	Glycylpeptide N-tetradecanoyltransferase, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P30419	astrocytic tumor glioblastoma malignant glioma ovarian cancer atypical teratoid rhabdoid tumor hypertensive disorder medulloblastoma primitive neuroectodermal tumor dermatomyositis lung cancer osteosarcoma psoriasis

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.