1RTK

Crystal Structure Analysis of the Bb segment of Factor B complexed with 4-guanidinobenzoic acid

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1rtka1	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Eukaryotic proteases	Factor B	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1rtka2	Alpha and beta proteins (a/b)	vWA-like	vWA-like	Integrin A (or I) domain	Complement factor B domain	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Eukaryotic proteases	8029932	4000286	SCOP2 (2022-06-29)
A	SCOP2 Family	Integrin A (or I) domain	8029933	4000639	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Trypsin-like serine proteases	8042311	3000114	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	vWA-like	8042312	3000832	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Trypsin_1	e1rtkA1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin_1	ECOD (1.6)
A	VWA	e1rtkA2	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: vWA-like	F: VWA	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.410	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	von Willebrand factor, type A domain	CATH (4.3.0)
A	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00092	von Willebrand factor type A domain (VWA)	von Willebrand factor type A domain	-	Domain
A	PF00089	Trypsin (Trypsin)	Trypsin	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Complement factor B Bb fragment	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity protein binding binding complement binding	biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus humoral immune response positive regulation of biological process complement activation, alternative pathway positive regulation of response to stimulus complement activation positive regulation of immune response response to stress biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus humoral immune response positive regulation of biological process complement activation, alternative pathway positive regulation of response to stimulus complement activation positive regulation of immune response response to stress innate immune response regulation of immune system process positive regulation of immune system process regulation of biological process immune response defense response biological regulation defense response to symbiont immune effector process regulation of response to stimulus immune system process defense response to other organism regulation of immune response activation of immune response organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	extracellular region extracellular space cellular anatomical entity blood microparticle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular membrane-bounded organelle cell periphery plasma membrane membrane extracellular region extracellular space cellular anatomical entity blood microparticle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular membrane-bounded organelle cell periphery plasma membrane membrane protein-containing complex catalytic complex classical-complement-pathway C3/C5 convertase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR011360	Complement B/C2	Family
A	IPR028341	Complement factor B	Family
A	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
A	IPR001314	Peptidase S1A, chymotrypsin family	Family
A	IPR033116	Serine proteases, trypsin family, serine active site	Active Site
A	IPR001254	Serine proteases, trypsin domain	Domain
A	IPR002035	von Willebrand factor, type A	Domain
A	IPR000436	Sushi/SCR/CCP domain	Domain
A	IPR018114	Serine proteases, trypsin family, histidine active site	Active Site
A	IPR035976	Sushi/SCR/CCP superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P00751	age-related macular degeneration complement factor b deficiency atypical hemolytic-uremic syndrome myasthenia gravis atypical hemolytic-uremic syndrome with B factor anomaly systemic lupus erythematosus ulcerative colitis hemolytic-uremic syndrome Libman-Sacks Disease macular degeneration membranous glomerulonephritis ovarian cancer age related macular degeneration 14 retinal degeneration wet macular degeneration age-related macular degeneration complement factor b deficiency atypical hemolytic-uremic syndrome myasthenia gravis atypical hemolytic-uremic syndrome with B factor anomaly systemic lupus erythematosus ulcerative colitis hemolytic-uremic syndrome Libman-Sacks Disease macular degeneration membranous glomerulonephritis ovarian cancer age related macular degeneration 14 retinal degeneration wet macular degeneration cervical cancer Hashimoto thyroiditis hypertensive disorder lung carcinoma neuromyelitis optica psoriasis skin basal cell carcinoma autism spectrum disorder brain injury heart disease non-alcoholic fatty liver disease psoriatic arthritis squamous cell lung carcinoma vitiligo endometriosis hemolytic anemia hepatitis B virus infection

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.