1R0D

HIP1R THATCH DOMAIN CORE

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1r0da_	All alpha proteins	I/LWEQ domain	I/LWEQ domain	I/LWEQ domain	Huntingtin interacting protein 12	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1r0db_	All alpha proteins	I/LWEQ domain	I/LWEQ domain	I/LWEQ domain	Huntingtin interacting protein 12	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth D]	d1r0dd_	All alpha proteins	I/LWEQ domain	I/LWEQ domain	I/LWEQ domain	Huntingtin interacting protein 12	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth E]	d1r0de_	All alpha proteins	I/LWEQ domain	I/LWEQ domain	I/LWEQ domain	Huntingtin interacting protein 12	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E [auth F]	d1r0df_	All alpha proteins	I/LWEQ domain	I/LWEQ domain	I/LWEQ domain	Huntingtin interacting protein 12	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F [auth G]	d1r0dg_	All alpha proteins	I/LWEQ domain	I/LWEQ domain	I/LWEQ domain	Huntingtin interacting protein 12	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G [auth H]	d1r0dh_	All alpha proteins	I/LWEQ domain	I/LWEQ domain	I/LWEQ domain	Huntingtin interacting protein 12	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H [auth I]	d1r0di_	All alpha proteins	I/LWEQ domain	I/LWEQ domain	I/LWEQ domain	Huntingtin interacting protein 12	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	I/LWEQ domain	8026287	4002528	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	I/LWEQ domain-like	8038666	3001382	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	I/LWEQ domain-like	8038666	3001382	SCOP2B (2022-06-29)
C [auth D]	SCOP2B Superfamily	I/LWEQ domain-like	8038666	3001382	SCOP2B (2022-06-29)
D [auth E]	SCOP2B Superfamily	I/LWEQ domain-like	8038666	3001382	SCOP2B (2022-06-29)
E [auth F]	SCOP2B Superfamily	I/LWEQ domain-like	8038666	3001382	SCOP2B (2022-06-29)
F [auth G]	SCOP2B Superfamily	I/LWEQ domain-like	8038666	3001382	SCOP2B (2022-06-29)
G [auth H]	SCOP2B Superfamily	I/LWEQ domain-like	8038666	3001382	SCOP2B (2022-06-29)
H [auth I]	SCOP2B Superfamily	I/LWEQ domain-like	8038666	3001382	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	I_LWEQ	e1r0dA1	A: alpha bundles	X: Four-helical up-and-down bundle	H: alpha-catenin-related	T: I/LWEQ domain (Pfam 01608)	F: I_LWEQ	ECOD (1.6)
B	I_LWEQ	e1r0dB1	A: alpha bundles	X: Four-helical up-and-down bundle	H: alpha-catenin-related	T: I/LWEQ domain (Pfam 01608)	F: I_LWEQ	ECOD (1.6)
C [auth D]	I_LWEQ	e1r0dD1	A: alpha bundles	X: Four-helical up-and-down bundle	H: alpha-catenin-related	T: I/LWEQ domain (Pfam 01608)	F: I_LWEQ	ECOD (1.6)
D [auth E]	I_LWEQ	e1r0dE1	A: alpha bundles	X: Four-helical up-and-down bundle	H: alpha-catenin-related	T: I/LWEQ domain (Pfam 01608)	F: I_LWEQ	ECOD (1.6)
E [auth F]	I_LWEQ	e1r0dF1	A: alpha bundles	X: Four-helical up-and-down bundle	H: alpha-catenin-related	T: I/LWEQ domain (Pfam 01608)	F: I_LWEQ	ECOD (1.6)
F [auth G]	I_LWEQ	e1r0dG1	A: alpha bundles	X: Four-helical up-and-down bundle	H: alpha-catenin-related	T: I/LWEQ domain (Pfam 01608)	F: I_LWEQ	ECOD (1.6)
G [auth H]	I_LWEQ	e1r0dH1	A: alpha bundles	X: Four-helical up-and-down bundle	H: alpha-catenin-related	T: I/LWEQ domain (Pfam 01608)	F: I_LWEQ	ECOD (1.6)
H [auth I]	I_LWEQ	e1r0dI1	A: alpha bundles	X: Four-helical up-and-down bundle	H: alpha-catenin-related	T: I/LWEQ domain (Pfam 01608)	F: I_LWEQ	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1410.10	Mainly Alpha	Up-down Bundle	I/LWEQ domain	I/LWEQ domain	CATH (4.3.0)
B	1.20.1410.10	Mainly Alpha	Up-down Bundle	I/LWEQ domain	I/LWEQ domain	CATH (4.3.0)
C [auth D]	1.20.1410.10	Mainly Alpha	Up-down Bundle	I/LWEQ domain	I/LWEQ domain	CATH (4.3.0)
D [auth E]	1.20.1410.10	Mainly Alpha	Up-down Bundle	I/LWEQ domain	I/LWEQ domain	CATH (4.3.0)
E [auth F]	1.20.1410.10	Mainly Alpha	Up-down Bundle	I/LWEQ domain	I/LWEQ domain	CATH (4.3.0)
F [auth G]	1.20.1410.10	Mainly Alpha	Up-down Bundle	I/LWEQ domain	I/LWEQ domain	CATH (4.3.0)
G [auth H]	1.20.1410.10	Mainly Alpha	Up-down Bundle	I/LWEQ domain	I/LWEQ domain	CATH (4.3.0)
H [auth I]	1.20.1410.10	Mainly Alpha	Up-down Bundle	I/LWEQ domain	I/LWEQ domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C [auth D], D [auth E], E [auth F], A, B, C [auth D], D [auth E], E [auth F], F [auth G], G [auth H], H [auth I]	PF01608	I/LWEQ domain (I_LWEQ)	I/LWEQ domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C [auth D], D [auth E], E [auth F], A, B, C [auth D], D [auth E], E [auth F], F [auth G], G [auth H], H [auth I]	Huntingtin Interacting Protein 12	binding phospholipid binding lipid binding phosphatidylinositol binding clathrin binding protein binding clathrin light chain binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding SH3 domain binding protein domain specific binding ion binding binding phospholipid binding lipid binding phosphatidylinositol binding clathrin binding protein binding clathrin light chain binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding SH3 domain binding protein domain specific binding ion binding anion binding phosphatidylinositol-3,4-bisphosphate binding small molecule binding identical protein binding phosphatidylinositol-3,5-bisphosphate binding phosphatidylinositol bisphosphate binding phosphatidylinositol phosphate binding protein heterodimerization activity protein dimerization activity phosphatidylinositol-4,5-bisphosphate binding protein homodimerization activity cargo adaptor activity clathrin adaptor activity protein-macromolecule adaptor activity molecular adaptor activity phosphatidylinositol-3,4,5-trisphosphate binding	regulation of protein stability biological regulation regulation of biological quality protein stabilization regulation of localization import into cell regulation of biological process regulation of cellular process regulation of cellular component organization regulation of transport transport regulation of vesicle-mediated transport establishment of localization vesicle-mediated transport regulation of protein stability biological regulation regulation of biological quality protein stabilization regulation of localization import into cell regulation of biological process regulation of cellular process regulation of cellular component organization regulation of transport transport regulation of vesicle-mediated transport establishment of localization vesicle-mediated transport cellular component organization localization cellular process cellular component organization or biogenesis endocytosis regulation of endocytosis positive regulation of programmed cell death regulation of apoptotic process positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death positive regulation of cellular process regulation of receptor-mediated endocytosis clathrin-dependent endocytosis receptor-mediated endocytosis regulation of clathrin-dependent endocytosis cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus signaling regulation of signal transduction cell surface receptor protein tyrosine kinase signaling pathway cell communication positive regulation of response to stimulus positive regulation of ERBB signaling pathway regulation of epidermal growth factor receptor signaling pathway epidermal growth factor receptor signaling pathway signal transduction enzyme-linked receptor protein signaling pathway positive regulation of epidermal growth factor receptor signaling pathway regulation of ERBB signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of response to stimulus ERBB signaling pathway regulation of cell communication positive regulation of signaling cell junction organization postsynapse organization synapse organization regulation of Arp2/3 complex-mediated actin nucleation regulation of cytoskeleton organization regulation of actin filament-based process negative regulation of biological process regulation of actin nucleation actin filament-based process negative regulation of cellular process negative regulation of supramolecular fiber organization negative regulation of actin nucleation negative regulation of Arp2/3 complex-mediated actin nucleation regulation of actin filament organization actin cytoskeleton organization negative regulation of cellular component organization negative regulation of cytoskeleton organization actin filament organization Arp2/3 complex-mediated actin nucleation regulation of organelle organization organelle organization negative regulation of organelle organization regulation of actin cytoskeleton organization regulation of supramolecular fiber organization actin nucleation supramolecular fiber organization cytoskeleton organization regulation of protein binding positive regulation of molecular function regulation of molecular function positive regulation of protein binding regulation of binding positive regulation of binding regulation of catalytic activity positive regulation of protein metabolic process positive regulation of peptidase activity positive regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of primary metabolic process positive regulation of metabolic process regulation of cysteine-type endopeptidase activity involved in apoptotic process organic substance metabolic process regulation of proteolysis proteolysis regulation of endopeptidase activity positive regulation of macromolecule metabolic process protein metabolic process activation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity organonitrogen compound metabolic process regulation of protein metabolic process regulation of peptidase activity positive regulation of catalytic activity primary metabolic process regulation of macromolecule metabolic process positive regulation of hydrolase activity positive regulation of cysteine-type endopeptidase activity regulation of hydrolase activity positive regulation of endopeptidase activity positive regulation of proteolysis metabolic process macromolecule metabolic process regulation of metabolic process negative regulation of programmed cell death negative regulation of apoptotic process positive regulation of clathrin coat assembly positive regulation of cellular component organization protein-containing complex organization positive regulation of cellular component biogenesis regulation of clathrin coat assembly regulation of cellular component biogenesis clathrin coat assembly cellular component biogenesis regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly regulation of platelet-derived growth factor receptor signaling pathway positive regulation of platelet-derived growth factor receptor-beta signaling pathway positive regulation of platelet-derived growth factor receptor signaling pathway platelet-derived growth factor receptor-beta signaling pathway platelet-derived growth factor receptor signaling pathway regulation of platelet-derived growth factor receptor-beta signaling pathway developmental process multicellular organism development multicellular organismal process digestive system development anatomical structure development system development regulation of cellular component size negative regulation of protein polymerization regulation of actin filament polymerization negative regulation of actin filament polymerization protein polymerization actin polymerization or depolymerization actin filament polymerization regulation of actin polymerization or depolymerization negative regulation of protein-containing complex assembly regulation of protein polymerization regulation of actin filament length regulation of anatomical structure size regulation of gastric acid secretion system process secretion digestive system process regulation of system process acid secretion regulation of digestive system process gastric acid secretion regulation of secretion digestion regulation of multicellular organismal process positive regulation of organelle organization apoptotic mitochondrial changes mitochondrial outer membrane permeabilization involved in programmed cell death mitochondrial membrane organization positive regulation of mitochondrial membrane permeability involved in apoptotic process positive regulation of mitochondrial membrane permeability positive regulation of membrane permeability positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of mitochondrial membrane permeability mitochondrial transport mitochondrion organization membrane organization apoptotic signaling pathway positive regulation of transport regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of mitochondrion organization regulation of membrane permeability regulation of mitochondrial membrane permeability involved in apoptotic process mitochondrial outer membrane permeabilization	clathrin-coated pit membrane cellular anatomical entity endomembrane system intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular vesicle intracellular membrane-bounded organelle intracellular organelle coated vesicle membrane cytoplasmic vesicle membrane bounding membrane of organelle clathrin-coated pit membrane cellular anatomical entity endomembrane system intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular vesicle intracellular membrane-bounded organelle intracellular organelle coated vesicle membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle clathrin-coated vesicle coated vesicle vesicle organelle membrane clathrin-coated vesicle membrane synapse cell junction glutamatergic synapse cytoskeleton intracellular non-membrane-bounded organelle non-membrane-bounded organelle neuron spine neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection postsynapse dendrite dendritic tree perinuclear region of cytoplasm cell body neuronal cell body mitochondrion cell periphery cell cortex plasma membrane plasma membrane region synaptic membrane apical part of cell apical plasma membrane ruffle cell leading edge leading edge membrane ruffle membrane cell projection membrane neuron projection cytoplasm cytoplasmic region plasma membrane bounded cell projection cytoplasm dendrite cytoplasm postsynaptic density neuron to neuron synapse postsynaptic specialization asymmetric synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C [auth D], D [auth E], E [auth F], A, B, C [auth D], D [auth E], E [auth F], F [auth G], G [auth H], H [auth I]	IPR008942	ENTH/VHS	Homologous Superfamily
A, B, C [auth D], D [auth E], E [auth F], A, B, C [auth D], D [auth E], E [auth F], F [auth G], G [auth H], H [auth I]	IPR030224	Sla2 family	Family
A, B, C [auth D], D [auth E], E [auth F], A, B, C [auth D], D [auth E], E [auth F], F [auth G], G [auth H], H [auth I]	IPR002558	I/LWEQ domain	Domain
A, B, C [auth D], D [auth E], E [auth F], A, B, C [auth D], D [auth E], E [auth F], F [auth G], G [auth H], H [auth I]	IPR032422	Huntingtin-interacting protein 1, clathrin-binding domain	Domain
A, B, C [auth D], D [auth E], E [auth F], A, B, C [auth D], D [auth E], E [auth F], F [auth G], G [auth H], H [auth I]	IPR011417	AP180 N-terminal homology (ANTH) domain	Domain
A, B, C [auth D], D [auth E], E [auth F], A, B, C [auth D], D [auth E], E [auth F], F [auth G], G [auth H], H [auth I]	IPR035964	I/LWEQ domain superfamily	Homologous Superfamily
A, B, C [auth D], D [auth E], E [auth F], A, B, C [auth D], D [auth E], E [auth F], F [auth G], G [auth H], H [auth I]	IPR013809	ENTH domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C [auth D], D [auth E], E [auth F], A, B, C [auth D], D [auth E], E [auth F], F [auth G], G [auth H], H [auth I]	Pharos: O75146	atrial fibrillation adrenal cortex carcinoma B-cell chronic lymphocytic leukemia malignant mesothelioma pancreatic intraductal papillary-mucinous carcinoma subependymal giant cell astrocytoma bipolar disorder oligodendroglioma pilocytic astrocytoma tuberculosis atypical teratoid rhabdoid tumor large cell medulloblastoma osteosarcoma pituitary cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.