Annotations: 1QKN

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1qkna_	All alpha proteins	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Estrogen receptor beta	RAT (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Nuclear receptor ligand-binding domain	8026344	4001384	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Nuclear receptor ligand-binding domain	8038723	3001442	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Hormone_recep_1	e1qknA1	A: alpha arrays	X: Nuclear receptor ligand-binding domain (From Topology)	H: Nuclear receptor ligand-binding domain (From Topology)	T: Nuclear receptor ligand-binding domain	F: Hormone_recep_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.565.10	Mainly Alpha	Orthogonal Bundle	Retinoid X Receptor	Retinoid X Receptor	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	ESTROGEN RECEPTOR BETA	estrogen binding binding hormone binding sequence-specific DNA binding DNA binding organic cyclic compound binding nucleic acid binding estradiol binding steroid binding lipid binding protein-containing complex binding chromatin binding promoter-specific chromatin binding steroid hormone binding estrogen binding binding hormone binding sequence-specific DNA binding DNA binding organic cyclic compound binding nucleic acid binding estradiol binding steroid binding lipid binding protein-containing complex binding chromatin binding promoter-specific chromatin binding steroid hormone binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity heterocyclic compound binding small molecule binding protein binding signaling receptor binding peroxisome proliferator activated receptor binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding estrogen response element binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding nuclear receptor activity molecular transducer activity ligand-activated transcription factor activity signaling receptor activity nuclear steroid receptor activity nuclear estrogen receptor activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding enzyme binding	response to stimulus response to chemical response to xenobiotic stimulus cellular response to stimulus response to organic substance regulation of cellular process intracellular receptor signaling pathway response to lipid signaling hormone-mediated signaling pathway cell communication cellular response to endogenous stimulus response to hormone response to steroid hormone response to stimulus response to chemical response to xenobiotic stimulus cellular response to stimulus response to organic substance regulation of cellular process intracellular receptor signaling pathway response to lipid signaling hormone-mediated signaling pathway cell communication cellular response to endogenous stimulus response to hormone response to steroid hormone androgen receptor signaling pathway signal transduction cellular response to organic substance cellular response to steroid hormone stimulus response to organic cyclic compound cellular response to hormone stimulus regulation of biological process response to endogenous stimulus biological regulation cellular response to organic cyclic compound cellular response to chemical stimulus steroid hormone mediated signaling pathway cellular response to lipid nuclear receptor signaling pathway cellular process intracellular steroid hormone receptor signaling pathway response to ketone response to oxygen-containing compound response to testosterone positive regulation of DNA-binding transcription factor activity cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of molecular function organic cyclic compound metabolic process regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process developmental process Sertoli cell proliferation multicellular organismal process cell population proliferation gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development epithelial cell proliferation system development head development brain development nervous system development cerebellum development central nervous system development metencephalon development hindbrain development intracellular estrogen receptor signaling pathway response to glucocorticoid response to corticosteroid response to dexamethasone negative regulation of metabolic process reactive oxygen species metabolic process negative regulation of biological process negative regulation of cellular metabolic process negative regulation of reactive oxygen species metabolic process negative regulation of cellular process regulation of reactive oxygen species metabolic process response to salt response to insecticide response to toxic substance cell death apoptotic signaling pathway hormone-mediated apoptotic signaling pathway apoptotic process programmed cell death response to estrogen cellular response to estrogen stimulus cellular response to xenobiotic stimulus negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process negative regulation of behavior regulation of behavior behavior regulation of multicellular organismal process negative regulation of multicellular organismal process positive regulation of cell communication positive regulation of signal transduction positive regulation of biological process regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette positive regulation of cellular process regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling response to activity hypothalamus development forebrain development diencephalon development limbic system development uterus development response to human chorionic gonadotropin response to gonadotropin regulation of cell population proliferation cellular response to oxygen-containing compound response to estradiol cellular response to estradiol stimulus response to phenylpropanoid response to hydroxyisoflavone response to genistein amygdala development response to magnetism cellular response to magnetism response to abiotic stimulus cellular response to abiotic stimulus cellular response to environmental stimulus ovulation cycle rhythmic process estrous cycle multicellular organismal reproductive process prostate gland development gland development urogenital system development positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death positive regulation of apoptotic process cell surface receptor protein tyrosine kinase signaling pathway positive regulation of ERBB signaling pathway regulation of epidermal growth factor receptor signaling pathway epidermal growth factor receptor signaling pathway enzyme-linked receptor protein signaling pathway positive regulation of epidermal growth factor receptor signaling pathway regulation of ERBB signaling pathway cell surface receptor signaling pathway ERBB signaling pathway female gonad development female sex differentiation development of primary female sexual characteristics ovarian follicle development epithelium development morphogenesis of an epithelium tissue development prostate gland epithelium morphogenesis prostate gland morphogenesis tissue morphogenesis anatomical structure morphogenesis gland morphogenesis animal organ morphogenesis response to nutrient levels cellular developmental process cell development epithelial cell differentiation Sertoli cell differentiation cell differentiation Sertoli cell development epithelial cell development negative regulation of cell population proliferation regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process response to bisphenol A genitalia development female genitalia development vagina development regulation of smooth muscle cell proliferation smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation muscle cell proliferation biological process involved in interspecies interaction between organisms response to other organism cellular response to lipopolysaccharide response to external stimulus cellular response to molecule of bacterial origin response to lipopolysaccharide response to biotic stimulus cellular response to biotic stimulus response to bacterium response to external biotic stimulus response to molecule of bacterial origin neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of programmed cell death negative regulation of apoptotic process regulation of neuron apoptotic process epithelial cell maturation involved in prostate gland development cell maturation epithelial cell differentiation involved in prostate gland development developmental maturation anatomical structure maturation epithelial cell maturation response to alcohol response to ethanol regulation of tube diameter system process regulation of tube size circulatory system process vascular process in circulatory system blood vessel diameter maintenance regulation of biological quality vasodilation blood circulation regulation of anatomical structure size learning or memory nervous system process cognition behavioral defense response fear response behavioral fear response defense response response to stress multicellular organismal response to stress neuron migration generation of neurons neurogenesis cell migration cell motility negative regulation of signaling negative regulation of cell communication negative regulation of intracellular steroid hormone receptor signaling pathway regulation of intracellular steroid hormone receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction regulation of androgen receptor signaling pathway negative regulation of androgen receptor signaling pathway negative regulation of feeding behavior feeding behavior regulation of feeding behavior	somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity intracellular anatomical structure cytoplasm perinuclear region of cytoplasm membrane-bounded organelle intracellular organelle mitochondrion organelle intracellular membrane-bounded organelle protein-containing complex somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity intracellular anatomical structure cytoplasm perinuclear region of cytoplasm membrane-bounded organelle intracellular organelle mitochondrion organelle intracellular membrane-bounded organelle protein-containing complex protein-DNA complex nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001628	Zinc finger, nuclear hormone receptor-type	Domain
A	IPR028355	Estrogen receptor beta/gamma	Family
A	IPR013088	Zinc finger, NHR/GATA-type	Homologous Superfamily
A	IPR024178	Estrogen receptor/oestrogen-related receptor	Family
A	IPR001723	Nuclear hormone receptor	Family
A	IPR000536	Nuclear hormone receptor, ligand-binding domain	Domain
A	IPR021064	Estrogen receptor beta-like, N-terminal	Domain
A	IPR035500	Nuclear hormone receptor-like domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.