1QD1

THE CRYSTAL STRUCTURE OF THE FORMIMINOTRANSFERASE DOMAIN OF FORMIMINOTRANSFERASE-CYCLODEAMINASE.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Structure Motif: Primary M-CSA Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1qd1a1	Alpha and beta proteins (a+b)	Ferredoxin-like	Formiminotransferase domain of formiminotransferase-cyclodeaminase.	Formiminotransferase domain of formiminotransferase-cyclodeaminase.	Formiminotransferase domain of formiminotransferase-cyclodeaminase.	pig (Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)
B	d1qd1b1	Alpha and beta proteins (a+b)	Ferredoxin-like	Formiminotransferase domain of formiminotransferase-cyclodeaminase.	Formiminotransferase domain of formiminotransferase-cyclodeaminase.	Formiminotransferase domain of formiminotransferase-cyclodeaminase.	pig (Sus scrofa ) [TaxId: 9823 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Formiminotransferase domain of formiminotransferase-cyclodeaminase.	8035670	3001350	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Formiminotransferase domain of formiminotransferase-cyclodeaminase.	8035674	3001350	SCOP2B (2022-06-29)
B	SCOP2 Family	Formiminotransferase domain of formiminotransferase-cyclodeaminase.	8023290	4001347	SCOP2 (2022-06-29)
B	SCOP2 Family	Formiminotransferase domain of formiminotransferase-cyclodeaminase.	8023294	4001347	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Formiminotransferase domain of formiminotransferase-cyclodeaminase.	8035670	3001350	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Formiminotransferase domain of formiminotransferase-cyclodeaminase.	8035674	3001350	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02971	e1qd1A2	A: a+b two layers	X: Alpha-beta plaits	H: Formiminotransferase domain of formiminotransferase-cyclodeaminase. (From Topology)	T: Formiminotransferase domain of formiminotransferase-cyclodeaminase.	F: PF02971	ECOD (1.6)
A	PF07837	e1qd1A1	A: a+b two layers	X: Alpha-beta plaits	H: Formiminotransferase domain of formiminotransferase-cyclodeaminase. (From Topology)	T: Formiminotransferase domain of formiminotransferase-cyclodeaminase.	F: PF07837	ECOD (1.6)
B	PF02971	e1qd1B2	A: a+b two layers	X: Alpha-beta plaits	H: Formiminotransferase domain of formiminotransferase-cyclodeaminase. (From Topology)	T: Formiminotransferase domain of formiminotransferase-cyclodeaminase.	F: PF02971	ECOD (1.6)
B	PF07837	e1qd1B1	A: a+b two layers	X: Alpha-beta plaits	H: Formiminotransferase domain of formiminotransferase-cyclodeaminase. (From Topology)	T: Formiminotransferase domain of formiminotransferase-cyclodeaminase.	F: PF07837	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.990.10	Alpha Beta	2-Layer Sandwich	Formiminotransferase-cyclodeaminase	Chain B, domain 1	CATH (4.3.0)
A	3.30.70.670	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Formiminotransferase, C-terminal subdomain	CATH (4.3.0)
B	3.30.990.10	Alpha Beta	2-Layer Sandwich	Formiminotransferase-cyclodeaminase	Chain B, domain 1	CATH (4.3.0)
B	3.30.70.670	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Formiminotransferase, C-terminal subdomain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02971	Formiminotransferase domain (FTCD)	Formiminotransferase domain	-	Domain
A, B	PF07837	Formiminotransferase domain, N-terminal subdomain (FTCD_N)	Formiminotransferase domain, N-terminal subdomain	The formiminotransferase (FT) domain of formiminotransferase- cyclodeaminase (FTCD) forms a homodimer, and each protomer comprises two subdomains. The N-terminal subdomain is made up of a six-stranded mixed beta-pleated sheet and five alpha helices, ...	The formiminotransferase (FT) domain of formiminotransferase- cyclodeaminase (FTCD) forms a homodimer, and each protomer comprises two subdomains. The N-terminal subdomain is made up of a six-stranded mixed beta-pleated sheet and five alpha helices, which are arranged on the external surface of the beta sheet. This, in turn, faces the beta-sheet of the C-terminal subdomain to form a double beta-sheet layer. The two subdomains are separated by a short linker sequence, which is not thought to be any more flexible than the remainder of the molecule. The substrate is predicted to form a number of contacts with residues found in both the N-terminal and C-terminal subdomains [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	FORMIMINOTRANSFERASE-CYCLODEAMINASE	transferase activity, transferring one-carbon groups transferase activity glutamate formimidoyltransferase activity hydroxymethyl-, formyl- and related transferase activity catalytic activity amide binding organic acid binding binding modified amino acid binding vitamin binding ion binding organic cyclic compound binding folic acid binding anion binding transferase activity, transferring one-carbon groups transferase activity glutamate formimidoyltransferase activity hydroxymethyl-, formyl- and related transferase activity catalytic activity amide binding organic acid binding binding modified amino acid binding vitamin binding ion binding organic cyclic compound binding folic acid binding anion binding carboxylic acid binding heterocyclic compound binding small molecule binding formimidoyltetrahydrofolate cyclodeaminase activity lyase activity ammonia-lyase activity carbon-nitrogen lyase activity	catabolic process oxoacid metabolic process amino acid metabolic process organic acid metabolic process histidine catabolic process organic acid catabolic process alpha-amino acid metabolic process glutamine family amino acid metabolic process cellular catabolic process organic substance metabolic process carboxylic acid catabolic process glutamate metabolic process amide catabolic process small molecule metabolic process catabolic process oxoacid metabolic process amino acid metabolic process organic acid metabolic process histidine catabolic process organic acid catabolic process alpha-amino acid metabolic process glutamine family amino acid metabolic process cellular catabolic process organic substance metabolic process carboxylic acid catabolic process glutamate metabolic process amide catabolic process small molecule metabolic process amide metabolic process histidine metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process cellular metabolic process dicarboxylic acid metabolic process carboxylic acid metabolic process histidine catabolic process to glutamate and formamide primary metabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process metabolic process cellular process small molecule catabolic process formamide metabolic process organic substance catabolic process histidine catabolic process to glutamate and formate monocarboxylic acid metabolic process formate metabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system microtubule organizing center cytoskeleton intracellular non-membrane-bounded organelle centriole microtubule cytoskeleton membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system microtubule organizing center cytoskeleton intracellular non-membrane-bounded organelle centriole microtubule cytoskeleton non-membrane-bounded organelle cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR037070	Formiminotransferase, C-terminal subdomain superfamily	Homologous Superfamily
A, B	IPR004227	Formiminotransferase catalytic domain	Domain
A, B	IPR036178	Formimidoyltransferase-cyclodeaminase-like superfamily	Homologous Superfamily
A, B	IPR013802	Formiminotransferase, C-terminal subdomain	Domain
A, B	IPR022384	Formiminotransferase catalytic domain superfamily	Homologous Superfamily
A, B	IPR012886	Formiminotransferase, N-terminal subdomain	Domain
A, B	IPR037064	Formiminotransferase, N-terminal subdomain superfamily	Homologous Superfamily
A, B	IPR007044	Cyclodeaminase/cyclohydrolase	Domain

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	glutamate formimidoyltransferase M-CSA #887	Tetrahydrofolate (THF)-dependent glutamate formiminotransferase is involved in the histidine utilisation pathway.	Defined by 1 residue: HIS:A-81 [auth A-82] \| Explore in 3D: M-CSA Motif Definition At least 2 residues must be present to support Structure Motif searching. EC: 2.1.2.5 (PDB Primary Data)

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