Annotations: 1QAX

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1qaxa1	Alpha and beta proteins (a+b)	Ferredoxin-like	NAD-binding domain of HMG-CoA reductase	NAD-binding domain of HMG-CoA reductase	NAD-binding domain of HMG-CoA reductase	(Pseudomonas sp. 'mevalonii ) [TaxId: 32044 ],	SCOPe (2.08)
A	d1qaxa2	Alpha and beta proteins (a+b)	Substrate-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	(Pseudomonas sp. 'mevalonii ) [TaxId: 32044 ],	SCOPe (2.08)
B	d1qaxb1	Alpha and beta proteins (a+b)	Ferredoxin-like	NAD-binding domain of HMG-CoA reductase	NAD-binding domain of HMG-CoA reductase	NAD-binding domain of HMG-CoA reductase	(Pseudomonas sp. 'mevalonii ) [TaxId: 32044 ],	SCOPe (2.08)
B	d1qaxb2	Alpha and beta proteins (a+b)	Substrate-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	(Pseudomonas sp. 'mevalonii ) [TaxId: 32044 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	NAD-binding domain of HMG-CoA reductase	8040282	3001200	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Substrate-binding domain of HMG-CoA reductase	8040285	3001471	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Substrate-binding domain of HMG-CoA reductase	8040285	3001471	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Substrate-binding domain of HMG-CoA reductase	8040285	3001471	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	NAD-binding domain of HMG-CoA reductase	8040282	3001200	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Substrate-binding domain of HMG-CoA reductase	8040285	3001471	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e1qaxA3	A: alpha arrays	X: RuvA-C	H: HMG-CoA reductase flap domain (From Topology)	T: HMG-CoA reductase flap domain	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF00368	e1qaxA2	A: a+b two layers	X: Alpha-beta plaits	H: HMG-CoA reductase	T: NAD-binding domain of HMG-CoA reductase	F: PF00368	ECOD (1.6)
A	PF00368	e1qaxA4	A: a+b two layers	X: Alpha-beta plaits	H: HMG-CoA reductase	T: Substrate-binding domain of HMG-CoA reductase	F: PF00368	ECOD (1.6)
B	PF00368	e1qaxB1	A: a+b two layers	X: Alpha-beta plaits	H: HMG-CoA reductase	T: NAD-binding domain of HMG-CoA reductase	F: PF00368	ECOD (1.6)
B	PF00368	e1qaxB2	A: a+b two layers	X: Alpha-beta plaits	H: HMG-CoA reductase	T: Substrate-binding domain of HMG-CoA reductase	F: PF00368	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.70.420	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain	CATH (4.3.0)
A	3.90.770.10	Alpha Beta	Alpha-Beta Complex	3-hydroxy-3-methylglutaryl-coenzyme A Reductase	Chain A, domain 2	CATH (4.3.0)
B	3.30.70.420	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain	CATH (4.3.0)
B	3.90.770.10	Alpha Beta	Alpha-Beta Complex	3-hydroxy-3-methylglutaryl-coenzyme A Reductase	Chain A, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00368	Hydroxymethylglutaryl-coenzyme A reductase (HMG-CoA_red)	Hydroxymethylglutaryl-coenzyme A reductase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	PROTEIN (3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE)	oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors hydroxymethylglutaryl-CoA reductase (NADPH) activity catalytic activity hydroxymethylglutaryl-CoA reductase (NADH) activity	ribose phosphate metabolic process nucleoside bisphosphate metabolic process purine nucleoside bisphosphate metabolic process ribonucleoside bisphosphate metabolic process carbohydrate derivative metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process organic substance metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process coenzyme A metabolic process ribose phosphate metabolic process nucleoside bisphosphate metabolic process purine nucleoside bisphosphate metabolic process ribonucleoside bisphosphate metabolic process carbohydrate derivative metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process organic substance metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process coenzyme A metabolic process nucleoside phosphate metabolic process organonitrogen compound metabolic process cellular metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process organic cyclic compound metabolic process organophosphate metabolic process metabolic process cellular process purine ribonucleotide metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR009029	Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily	Homologous Superfamily
A, B	IPR023074	Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily	Homologous Superfamily
A, B	IPR009023	Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily	Homologous Superfamily
A, B	IPR002202	Hydroxymethylglutaryl-CoA reductase, class I/II	Family
A, B	IPR004553	Hydroxymethylglutaryl-CoA reductase, bacterial-type	Family
A, B	IPR023076	Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.