1Q7F

Brain Tumor NHL domain

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1q7fa_	All beta proteins	6-bladed beta-propeller	NHL repeat	NHL repeat	Brain tumor cg10719-pa	fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
B	d1q7fb_	All beta proteins	6-bladed beta-propeller	NHL repeat	NHL repeat	Brain tumor cg10719-pa	fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	NHL repeat-like	8027431	4000932	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	NHL repeat-like	8039810	3000174	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	NHL repeat-like	8039810	3000174	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DUF5128	e1q7fA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: DUF5128	ECOD (1.6)
B	DUF5128	e1q7fB1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: DUF5128	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.120.10.30	Mainly Beta	6 Propeller	Neuraminidase	TolB, C-terminal domain	CATH (4.3.0)
B	2.120.10.30	Mainly Beta	6 Propeller	Neuraminidase	TolB, C-terminal domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01436	NHL repeat (NHL)	NHL repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	brain tumor CG10719-PA	translation regulator activity mRNA 3'-UTR binding RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding translation repressor activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	developmental process neuroblast proliferation multicellular organismal process cell population proliferation cellular developmental process nervous system development generation of neurons neurogenesis multicellular organism development cell differentiation anatomical structure development cellular process neural precursor cell proliferation system development developmental process neuroblast proliferation multicellular organismal process cell population proliferation cellular developmental process nervous system development generation of neurons neurogenesis multicellular organism development cell differentiation anatomical structure development cellular process neural precursor cell proliferation system development head development central nervous system development animal organ development brain development regulation of multicellular organismal development regulation of biological process regulation of cellular process regulation of developmental process biological regulation cell development regulation of neurogenesis regulation of cell differentiation regulation of cell development regulation of nervous system development regulation of multicellular organismal process cellular biosynthetic process organonitrogen compound biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process organonitrogen compound metabolic process cellular metabolic process regulation of protein metabolic process negative regulation of metabolic process regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process regulation of translation negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process sexual reproduction reproductive process oogenesis multicellular organismal reproductive process cellular process involved in reproduction in multicellular organism female gamete generation developmental process involved in reproduction gamete generation germ cell development segmentation pattern specification process regionalization neuroblast fate commitment neuroblast division neuroblast differentiation asymmetric cell division asymmetric neuroblast division cell division asymmetric neuroblast division resulting in ganglion mother cell formation cell fate commitment negative regulation of neural precursor cell proliferation regulation of neuroblast proliferation negative regulation of neuroblast proliferation negative regulation of neurogenesis negative regulation of nervous system development negative regulation of cell differentiation regulation of neural precursor cell proliferation negative regulation of cell population proliferation negative regulation of developmental process negative regulation of cell development regulation of cell population proliferation negative regulation of multicellular organismal process neuroblast development neuron differentiation regulation of localization import into cell cellular localization regulation of cellular component organization transport synaptic vesicle cycle regulation of synaptic vesicle recycling vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse cellular component organization localization synaptic vesicle recycling regulation of synaptic vesicle endocytosis establishment of localization in cell cellular component organization or biogenesis regulation of endocytosis synaptic vesicle endocytosis regulation of transport regulation of vesicle-mediated transport establishment of localization endocytosis cell fate determination ganglion mother cell fate determination RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process rRNA transcription rRNA metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process ncRNA metabolic process organic cyclic compound biosynthetic process neuroblast fate determination regulation of growth developmental growth cellular component biogenesis cellular component assembly neuromuscular junction development cell junction assembly regulation of synaptic assembly at neuromuscular junction regulation of synapse structure or activity synapse organization regulation of biological quality regulation of synapse assembly regulation of neuromuscular junction development regulation of developmental growth growth regulation of cellular component biogenesis regulation of cell junction assembly regulation of synapse organization cell junction organization synaptic assembly at neuromuscular junction synapse assembly ventral cord development	cell periphery cell cortex intracellular anatomical structure basal part of cell cell cortex region cellular anatomical entity cytoplasm cytoplasmic region basal cortex cytosol somatodendritic compartment cell body neuronal cell body apical part of cell cell periphery cell cortex intracellular anatomical structure basal part of cell cell cortex region cellular anatomical entity cytoplasm cytoplasmic region basal cortex cytosol somatodendritic compartment cell body neuronal cell body apical part of cell apical cortex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR011042	Six-bladed beta-propeller, TolB-like	Homologous Superfamily
A, B	IPR001258	NHL repeat	Repeat
A, B	IPR000315	B-box-type zinc finger	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.