1PYT

TERNARY COMPLEX OF PROCARBOXYPEPTIDASE A, PROPROTEINASE E, AND CHYMOTRYPSINOGEN C

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1pyta_	Alpha and beta proteins (a+b)	Ferredoxin-like	Protease propeptides/inhibitors	Pancreatic carboxypeptidase, activation domain	Procarboxypeptidase A	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
B	d1pytb_	Alpha and beta proteins (a/b)	Phosphorylase/hydrolase-like	Zn-dependent exopeptidases	Pancreatic carboxypeptidases	Carboxypeptidase A	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
C	d1pytc_	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Eukaryotic proteases	Procarboxypeptidase A-S6 subunit III (zymogen E)	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
D	d1pytd_	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Eukaryotic proteases	(alpha,gamma)-chymotrypsin(ogen)	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Pancreatic carboxypeptidase activation domain	8022862	4001250	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Protease propeptides/inhibitors	8035242	3001155	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Zn-dependent exopeptidases	8044569	3000662	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Trypsin-like serine proteases	8042192	3000114	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02244	e1pytA1	A: a+b two layers	X: Alpha-beta plaits	H: Protease propeptides/inhibitors (From Topology)	T: Protease propeptides/inhibitors	F: PF02244	ECOD (1.6)
B	PF00246	e1pytB1	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Zn-dependent exopeptidases (From Topology)	T: Zn-dependent exopeptidases	F: PF00246	ECOD (1.6)
C	PF00089	e1pytC1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: PF00089	ECOD (1.6)
D	PF00089	e1pytD1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: PF00089	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.70.340	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Metallocarboxypeptidase-like	CATH (4.3.0)
B	3.40.630.10	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Zn peptidases	CATH (4.3.0)
C	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)
D	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02244	Carboxypeptidase activation peptide (Propep_M14)	Carboxypeptidase activation peptide	Carboxypeptidases are found in abundance in pancreatic secretions. The pro-segment moiety (activation peptide) accounts for up to a quarter of the total length of the peptidase, and is responsible for modulation of folding and activity of the pro- ...	Carboxypeptidases are found in abundance in pancreatic secretions. The pro-segment moiety (activation peptide) accounts for up to a quarter of the total length of the peptidase, and is responsible for modulation of folding and activity of the pro-enzyme.	Domain
B	PF00246	Zinc carboxypeptidase (Peptidase_M14)	Zinc carboxypeptidase	-	Domain
C	PF00089	Trypsin (Trypsin)	Trypsin	-	Domain
D	PF00089	Trypsin (Trypsin)	Trypsin	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	PROCARBOXYPEPTIDASE A	peptidase activity catalytic activity, acting on a protein metallocarboxypeptidase activity hydrolase activity metallopeptidase activity exopeptidase activity catalytic activity metalloexopeptidase activity carboxypeptidase activity cation binding transition metal ion binding zinc ion binding ion binding binding peptidase activity catalytic activity, acting on a protein metallocarboxypeptidase activity hydrolase activity metallopeptidase activity exopeptidase activity catalytic activity metalloexopeptidase activity carboxypeptidase activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding	organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process icosanoid metabolic process leukotriene metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process small molecule metabolic process cellular process organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process icosanoid metabolic process leukotriene metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process small molecule metabolic process cellular process organic acid metabolic process	extracellular region extracellular space cellular anatomical entity
B	PROCARBOXYPEPTIDASE A	peptidase activity catalytic activity, acting on a protein metallocarboxypeptidase activity hydrolase activity metallopeptidase activity exopeptidase activity catalytic activity metalloexopeptidase activity carboxypeptidase activity cation binding transition metal ion binding zinc ion binding ion binding binding peptidase activity catalytic activity, acting on a protein metallocarboxypeptidase activity hydrolase activity metallopeptidase activity exopeptidase activity catalytic activity metalloexopeptidase activity carboxypeptidase activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding	organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process icosanoid metabolic process leukotriene metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process small molecule metabolic process cellular process organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process icosanoid metabolic process leukotriene metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process small molecule metabolic process cellular process organic acid metabolic process	extracellular region extracellular space cellular anatomical entity
C	PROPROTEINASE E	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity	organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process multicellular organismal process digestion	extracellular region extracellular space cellular anatomical entity
D	CHYMOTRYPSINOGEN C	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity	organic substance metabolic process organonitrogen compound metabolic process proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	extracellular region extracellular space cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036990	Metallocarboxypeptidase-like, propeptide	Homologous Superfamily
A	IPR034248	Carboxypeptidase A, carboxypeptidase domain	Domain
A	IPR003146	Carboxypeptidase, activation peptide	Domain
A	IPR000834	Peptidase M14, carboxypeptidase A	Domain
B	IPR036990	Metallocarboxypeptidase-like, propeptide	Homologous Superfamily
B	IPR034248	Carboxypeptidase A, carboxypeptidase domain	Domain
B	IPR003146	Carboxypeptidase, activation peptide	Domain
B	IPR000834	Peptidase M14, carboxypeptidase A	Domain
C	IPR001254	Serine proteases, trypsin domain	Domain
C	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
C	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
C	IPR018114	Serine proteases, trypsin family, histidine active site	Active Site
C	IPR001314	Peptidase S1A, chymotrypsin family	Family
C	IPR033116	Serine proteases, trypsin family, serine active site	Active Site
D	IPR001254	Serine proteases, trypsin domain	Domain
D	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
D	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
D	IPR018114	Serine proteases, trypsin family, histidine active site	Active Site
D	IPR001314	Peptidase S1A, chymotrypsin family	Family
D	IPR033116	Serine proteases, trypsin family, serine active site	Active Site