1PNT

CRYSTAL STRUCTURE OF BOVINE HEART PHOSPHOTYROSYL PHOSPHATASE AT 2.2 ANGSTROMS RESOLUTION

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Structure Motif: Primary M-CSA Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1pnta_	Alpha and beta proteins (a/b)	Phosphotyrosine protein phosphatases I-like	Phosphotyrosine protein phosphatases I	Low-molecular-weight phosphotyrosine protein phosphatases	Tyrosine phosphatase	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Phosphotyrosine protein phosphatases I	8044340	3000290	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01451	e1pntA1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: Phosphotyrosine protein phosphatases I-like	F: PF01451	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.2300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Response regulator	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01451	Low molecular weight phosphotyrosine protein phosphatase (LMWPc)	Low molecular weight phosphotyrosine protein phosphatase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	ACID PHOSPHATASE	phosphoric ester hydrolase activity phosphoprotein phosphatase activity non-membrane spanning protein tyrosine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds protein tyrosine phosphatase activity phosphatase activity hydrolase activity catalytic activity acid phosphatase activity	-	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002115	Protein-tyrosine phosphatase, low molecular weight, mammalian	Family
A	IPR017867	Protein-tyrosine phosphatase, low molecular weight	Family
A	IPR036196	Phosphotyrosine protein phosphatase I superfamily	Homologous Superfamily
A	IPR023485	Phosphotyrosine protein phosphatase I	Domain

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	low molecular weight phosphotyrosine protein phosphatase M-CSA #462	Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. It is part of the PTPase superfamily. Has high homology to the Saccharomyces cerevisiae protein. Has conserved catalytic components, in particular the CXXXXXRS/T 'P loop'. The mechanism is therefore thought to be the same as that of the rest of the superfamily.	Defined by 6 residues: CYS:A-12ASN:A-15CYS:A-17ARG:A-18SER:A-19ASP:A-129 \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 3.1.3.2 (PDB Primary Data) Search M-CSA Motif + EC 3.1.3.2

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.