Annotations: 1PGU

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1pgua1	All beta proteins	7-bladed beta-propeller	WD40 repeat-like	WD40-repeat	Actin interacting protein 1	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
B	d1pgub1	All beta proteins	7-bladed beta-propeller	WD40 repeat-like	WD40-repeat	Actin interacting protein 1	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	WD40-repeat	8022309	4002744	SCOP2 (2022-06-29)
A	SCOP2 Family	WD40-repeat	8022310	4002744	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	WD40 repeat-like	8034689	3001694	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	WD40 repeat-like	8034690	3001694	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	WD40 repeat-like	8034689	3001694	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	WD40 repeat-like	8034690	3001694	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ANAPC4_WD40_9	e1pguA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_9	ECOD (1.6)
A	ANAPC4_WD40_1	e1pguA2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_1	ECOD (1.6)
B	ANAPC4_WD40_9	e1pguB3	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_9	ECOD (1.6)
B	ANAPC4_WD40_5	e1pguB2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_5	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
B	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Actin interacting protein 1	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding	regulation of cytokinesis regulation of biological process regulation of cellular process negative regulation of cytokinesis regulation of cell cycle process biological regulation negative regulation of biological process negative regulation of cell cycle cytokinesis negative regulation of cell cycle process regulation of cell division negative regulation of cell division negative regulation of cellular process cellular process regulation of cytokinesis regulation of biological process regulation of cellular process negative regulation of cytokinesis regulation of cell cycle process biological regulation negative regulation of biological process negative regulation of cell cycle cytokinesis negative regulation of cell cycle process regulation of cell division negative regulation of cell division negative regulation of cellular process cellular process cell cycle cell division regulation of cell cycle cell cycle process cellular component disassembly actin polymerization or depolymerization actin cytoskeleton organization protein-containing complex organization actin filament organization protein-containing complex disassembly actin filament depolymerization cellular component organization organelle organization actin filament-based process cellular component organization or biogenesis supramolecular fiber organization protein depolymerization cytoskeleton organization regulation of cellular component size regulation of protein-containing complex disassembly regulation of actin filament depolymerization cellular component biogenesis actin filament capping cellular component assembly negative regulation of supramolecular fiber organization regulation of biological quality negative regulation of actin filament polymerization barbed-end actin filament capping negative regulation of cellular component organization regulation of organelle organization negative regulation of protein depolymerization negative regulation of protein-containing complex assembly regulation of protein polymerization regulation of supramolecular fiber organization regulation of cytoskeleton organization regulation of cellular component organization regulation of actin filament-based process regulation of protein-containing complex assembly negative regulation of protein-containing complex disassembly protein-containing complex assembly negative regulation of protein polymerization regulation of actin filament polymerization protein polymerization regulation of actin filament organization actin filament polymerization regulation of protein depolymerization negative regulation of cytoskeleton organization regulation of actin polymerization or depolymerization regulation of cellular component biogenesis negative regulation of organelle organization regulation of actin filament length regulation of actin cytoskeleton organization negative regulation of actin filament depolymerization regulation of anatomical structure size	intracellular anatomical structure cell cortex cortical cytoskeleton cellular anatomical entity actin cytoskeleton intracellular organelle cell periphery endocytic patch cytoskeleton organelle intracellular non-membrane-bounded organelle cortical actin cytoskeleton actin cortical patch cytoplasm intracellular anatomical structure cell cortex cortical cytoskeleton cellular anatomical entity actin cytoskeleton intracellular organelle cell periphery endocytic patch cytoskeleton organelle intracellular non-membrane-bounded organelle cortical actin cytoskeleton actin cortical patch cytoplasm non-membrane-bounded organelle cell projection mating projection cell tip mating projection tip cell pole plasma membrane bounded cell projection site of polarized growth polymeric cytoskeletal fiber actin filament supramolecular fiber supramolecular polymer supramolecular complex membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A, B	IPR001680	WD40 repeat	Repeat
A, B	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.