1PGG

PROSTAGLANDIN H2 SYNTHASE-1 COMPLEXED WITH 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID (IODOINDOMETHACIN), TRANS MODEL

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1pgga1	All alpha proteins	Heme-dependent peroxidases	Heme-dependent peroxidases	Myeloperoxidase-like	Prostaglandin H2 synthase	(Ovis aries ) [TaxId: 9940 ],	SCOPe (2.08)
A	d1pgga2	Small proteins	Knottins (small inhibitors, toxins, lectins)	EGF/Laminin	EGF-type module	Prostaglandin H2 synthase-1, EGF-like module	(Ovis aries ) [TaxId: 9940 ],	SCOPe (2.08)
B	d1pggb1	All alpha proteins	Heme-dependent peroxidases	Heme-dependent peroxidases	Myeloperoxidase-like	Prostaglandin H2 synthase	(Ovis aries ) [TaxId: 9940 ],	SCOPe (2.08)
B	d1pggb2	Small proteins	Knottins (small inhibitors, toxins, lectins)	EGF/Laminin	EGF-type module	Prostaglandin H2 synthase-1, EGF-like module	(Ovis aries ) [TaxId: 9940 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	EGF/Laminin-like	8039679	3000412	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Heme-dependent peroxidases	8039678	3000844	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Heme-dependent peroxidases	8039678	3000844	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	EGF/Laminin-like	8039679	3000412	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF03098	e1pggA1	A: alpha complex topology	X: Heme-dependent peroxidases (From Topology)	H: Heme-dependent peroxidases (From Topology)	T: Heme-dependent peroxidases	F: PF03098	ECOD (1.6)
A	PF00008	e1pggA2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: PF00008	ECOD (1.6)
B	PF03098	e1pggB1	A: alpha complex topology	X: Heme-dependent peroxidases (From Topology)	H: Heme-dependent peroxidases (From Topology)	T: Heme-dependent peroxidases	F: PF03098	ECOD (1.6)
B	PF00008	e1pggB2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: PF00008	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF03098	Animal haem peroxidase (An_peroxidase)	Animal haem peroxidase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	PROSTAGLANDIN H2 SYNTHASE-1	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor catalytic activity organic cyclic compound binding tetrapyrrole binding heme binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen identical protein binding protein binding binding protein homodimerization activity protein dimerization activity peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor catalytic activity organic cyclic compound binding tetrapyrrole binding heme binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen prostaglandin-endoperoxide synthase activity dioxygenase activity cation binding ion binding metal ion binding small molecule binding	multicellular organismal process system process circulatory system process regulation of blood pressure biological regulation regulation of biological quality blood circulation icosanoid metabolic process prostaglandin metabolic process unsaturated fatty acid metabolic process oxoacid metabolic process cellular biosynthetic process lipid biosynthetic process organic acid biosynthetic process multicellular organismal process system process circulatory system process regulation of blood pressure biological regulation regulation of biological quality blood circulation icosanoid metabolic process prostaglandin metabolic process unsaturated fatty acid metabolic process oxoacid metabolic process cellular biosynthetic process lipid biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process organic substance metabolic process prostanoid metabolic process icosanoid biosynthetic process organic substance biosynthetic process small molecule metabolic process prostaglandin biosynthetic process prostanoid biosynthetic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process cellular metabolic process carboxylic acid metabolic process primary metabolic process fatty acid biosynthetic process unsaturated fatty acid biosynthetic process biosynthetic process cellular lipid metabolic process metabolic process cellular process monocarboxylic acid metabolic process lipid metabolic process long-chain fatty acid metabolic process cyclooxygenase pathway arachidonic acid metabolic process olefinic compound metabolic process response to oxidative stress response to stimulus response to stress	membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle cellular anatomical entity cytoplasm organelle subcompartment membrane endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle cellular anatomical entity cytoplasm organelle subcompartment membrane endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR019791	Haem peroxidase, animal-type	Family
A, B	IPR037120	Haem peroxidase domain superfamily, animal type	Homologous Superfamily
A, B	IPR010255	Haem peroxidase superfamily	Homologous Superfamily
A, B	IPR000742	EGF-like domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.