Annotations: 1P9M

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1p9ma1	All beta proteins	Immunoglobulin-like beta-sandwich	Fibronectin type III	Fibronectin type III	Cytokine receptor gp130 cytokine-binding domains	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1p9mb_	All alpha proteins	4-helical cytokines	4-helical cytokines	Long-chain cytokines	Interleukin-6	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1p9mc1	All beta proteins	Immunoglobulin-like beta-sandwich	Fibronectin type III	Fibronectin type III	Interleukin-6 receptor alpha chain, domains 2 and 3	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Fibronectin type III	8055533	3002063	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Fibronectin type III	8055145	3002063	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	4-helical cytokines	8037068	3001717	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Fibronectin type III	8055539	3002063	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Fibronectin type III	8055153	3002063	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	IL6Ra-bind	e1p9mA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: IL6Ra-bind	ECOD (1.6)
A	Lep_receptor_Ig	e1p9mA3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Lep_receptor_Ig	ECOD (1.6)
A	fn3_6	e1p9mA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: fn3_6	ECOD (1.6)
B	IL6	e1p9mB1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: 4-helical cytokines (From Topology)	T: 4-helical cytokines	F: IL6	ECOD (1.6)
C	IL6Ra-bind	e1p9mC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: IL6Ra-bind	ECOD (1.6)
C	fn3_6	e1p9mC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: fn3_6	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	1.20.1250.10	Mainly Alpha	Up-down Bundle	Growth Hormone	Chain: A	CATH (4.3.0)
C	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A	IL6ST (Interleukin-6 receptor subunit beta)	1C-LIKE-2F-DOMAIN	Homo sapiens (human)	IL6ST	C-LIKE-DOMAIN C-LIKE, F-LIKE-DOMAIN F-DOMAIN	RPI	1C-LIKE-2F-DOMAIN	IMGT (202415-0)
C	IL6R (Interleukin-6 receptor subunit alpha)	2F-DOMAIN	Homo sapiens (human)	IL6R	F-LIKE-DOMAIN F-DOMAIN	RPI	2F-DOMAIN	IMGT (202415-0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00041	Fibronectin type III domain (fn3)	Fibronectin type III domain	-	Domain
A	PF09240	Interleukin-6 receptor alpha chain, binding (IL6Ra-bind)	Interleukin-6 receptor alpha chain, binding	Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6 [1].	Domain
A	PF06328	Ig-like C2-type domain (Lep_receptor_Ig)	Ig-like C2-type domain	This domain is a ligand-binding immunoglobulin-like domain [1]. The two cysteine residues form a disulphide bridge.	Domain
B	PF00489	Interleukin-6/G-CSF/MGF family (IL6)	Interleukin-6/G-CSF/MGF family	-	Domain
C	PF09240	Interleukin-6 receptor alpha chain, binding (IL6Ra-bind)	Interleukin-6 receptor alpha chain, binding	Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6 [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Interleukin-6 receptor beta chain	protein tyrosine kinase activator activity enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity molecular transducer activity coreceptor activity signaling receptor activity interleukin-11 receptor activity transmembrane signaling receptor activity protein tyrosine kinase activator activity enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity molecular transducer activity coreceptor activity signaling receptor activity interleukin-11 receptor activity transmembrane signaling receptor activity cytokine receptor activity immune receptor activity identical protein binding protein binding binding ciliary neurotrophic factor receptor binding signaling receptor binding cytokine receptor binding interleukin-11 binding growth factor binding cytokine binding scaffold protein binding interleukin-27 receptor activity interleukin-17 receptor activity ciliary neurotrophic factor receptor activity	cellular response to stimulus response to organic substance regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to stimulus response to organic substance regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular process cellular response to organic substance signal transduction immune response regulation of adaptive immune response positive regulation of biological process adaptive immune response positive regulation of response to stimulus regulation of response to stimulus positive regulation of immune response immune system process regulation of immune response regulation of immune system process positive regulation of adaptive immune response positive regulation of immune system process regulation of defense response regulation of response to external stimulus defense response response to external stimulus regulation of inflammatory response positive regulation of acute inflammatory response positive regulation of response to external stimulus positive regulation of inflammatory response response to stress regulation of response to stress positive regulation of defense response regulation of acute inflammatory response inflammatory response acute inflammatory response multicellular organismal process regulation of body fluid levels homotypic cell-cell adhesion regulation of cell activation positive regulation of cell-cell adhesion cell adhesion cell-cell adhesion coagulation regulation of cell-cell adhesion regulation of multicellular organismal process regulation of biological quality response to wounding positive regulation of cellular process wound healing regulation of homotypic cell-cell adhesion positive regulation of cell adhesion regulation of cell adhesion cell activation hemostasis platelet aggregation blood coagulation regulation of platelet activation regulation of platelet aggregation positive regulation of homotypic cell-cell adhesion positive regulation of platelet aggregation platelet activation leukemia inhibitory factor signaling pathway enzyme-linked receptor protein signaling pathway developmental process epithelium development digestive system development cellular developmental process intestinal epithelial cell differentiation tube development intestinal epithelial cell development cell development tissue development digestive tract development epithelial cell differentiation multicellular organism development epithelial cell development columnar/cuboidal epithelial cell development cell differentiation anatomical structure development columnar/cuboidal epithelial cell differentiation system development muscle hypertrophy regulation of muscle adaptation system process positive regulation of cardiac muscle hypertrophy regulation of system process striated muscle hypertrophy regulation of muscle system process muscle system process regulation of cardiac muscle hypertrophy regulation of muscle hypertrophy muscle adaptation positive regulation of muscle hypertrophy cardiac muscle hypertrophy positive regulation of multicellular organismal process positive regulation of cell population proliferation regulation of leukocyte activation positive regulation of cell activation T cell activation lymphocyte proliferation positive regulation of leukocyte activation regulation of leukocyte proliferation cell population proliferation positive regulation of T cell activation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation regulation of cell population proliferation mononuclear cell proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation positive regulation of lymphocyte activation positive regulation of mononuclear cell proliferation T cell proliferation regulation of lymphocyte proliferation regulation of T cell activation regulation of T cell proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process regulation of cytokine production organic substance biosynthetic process cytokine production positive regulation of macromolecule metabolic process regulation of vascular endothelial growth factor production regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression vascular endothelial growth factor production biosynthetic process positive regulation of gene expression positive regulation of vascular endothelial growth factor production regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process positive regulation of cellular biosynthetic process negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death ciliary neurotrophic factor-mediated signaling pathway neuron apoptotic process negative regulation of neuron apoptotic process regulation of neuron apoptotic process interleukin-6-mediated signaling pathway response to interleukin-6 cellular response to interleukin-6 regulation of osteoblast differentiation regulation of developmental process regulation of cell differentiation osteoblast differentiation positive regulation of developmental process positive regulation of osteoblast differentiation ossification positive regulation of cell differentiation positive regulation of phosphorylation positive regulation of phosphate metabolic process regulation of primary metabolic process regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process protein modification process phosphorus metabolic process positive regulation of protein phosphorylation tyrosine phosphorylation of STAT protein protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process macromolecule modification regulation of phosphorus metabolic process cell surface receptor signaling pathway via STAT regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process peptidyl-tyrosine modification positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process protein metabolic process organonitrogen compound metabolic process regulation of tyrosine phosphorylation of STAT protein regulation of peptidyl-tyrosine phosphorylation positive regulation of tyrosine phosphorylation of STAT protein regulation of phosphorylation peptidyl-tyrosine phosphorylation cell surface receptor signaling pathway via JAK-STAT interleukin-27-mediated signaling pathway positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction regulation of signaling Notch signaling pathway regulation of Notch signaling pathway regulation of cell communication positive regulation of Notch signaling pathway positive regulation of signaling interleukin-11-mediated signaling pathway negative regulation of signaling negative regulation of cell communication negative regulation of response to stimulus negative regulation of interleukin-6-mediated signaling pathway regulation of cytokine-mediated signaling pathway negative regulation of signal transduction regulation of interleukin-6-mediated signaling pathway regulation of response to cytokine stimulus negative regulation of response to cytokine stimulus negative regulation of cytokine-mediated signaling pathway carbohydrate metabolic process energy derivation by oxidation of organic compounds glycogen metabolic process generation of precursor metabolites and energy glucan metabolic process polysaccharide metabolic process energy reserve metabolic process oncostatin-M-mediated signaling pathway positive regulation of nervous system development astrocyte differentiation regulation of neurogenesis regulation of gliogenesis regulation of astrocyte differentiation positive regulation of gliogenesis regulation of cell development regulation of nervous system development neurogenesis gliogenesis positive regulation of neurogenesis positive regulation of astrocyte differentiation regulation of multicellular organismal development positive regulation of cell development regulation of glial cell differentiation nervous system development positive regulation of glial cell differentiation central nervous system development glial cell differentiation CD4-positive or CD8-positive, alpha-beta T cell lineage commitment adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains mononuclear cell differentiation lymphocyte differentiation cell activation involved in immune response CD4-positive, alpha-beta T cell differentiation CD4-positive, alpha-beta T cell differentiation involved in immune response alpha-beta T cell differentiation involved in immune response alpha-beta T cell differentiation T cell activation involved in immune response alpha-beta T cell activation involved in immune response CD4-positive, alpha-beta T cell activation leukocyte activation involved in immune response alpha-beta T cell activation T cell differentiation CD4-positive, alpha-beta T cell lineage commitment lymphocyte activation involved in immune response T-helper cell differentiation alpha-beta T cell lineage commitment hemopoiesis T-helper cell lineage commitment T cell differentiation involved in immune response T cell lineage commitment immune effector process T-helper 17 cell lineage commitment positive T cell selection T cell selection T-helper 17 cell differentiation cell fate commitment leukocyte differentiation T-helper 17 type immune response	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle protein-containing complex plasma membrane protein complex plasma membrane signaling receptor complex ciliary neurotrophic factor receptor complex membrane protein complex receptor complex somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection interleukin-6 receptor complex oncostatin-M receptor complex cell body neuronal cell body membrane microdomain membrane raft
B	Interleukin-6	protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity interleukin-6 receptor binding cytokine receptor binding growth factor receptor binding cytokine activity	developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of developmental process blood vessel morphogenesis tube development biological regulation angiogenesis vasculature development regulation of vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of developmental process blood vessel morphogenesis tube development biological regulation angiogenesis vasculature development regulation of vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis regulation of angiogenesis anatomical structure development anatomical structure formation involved in morphogenesis regulation of multicellular organismal process regulation of anatomical structure morphogenesis blood vessel development system development regulation of defense response response to stimulus regulation of response to external stimulus defense response positive regulation of biological process response to external stimulus regulation of inflammatory response positive regulation of acute inflammatory response positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stimulus response to stress regulation of response to stress positive regulation of defense response regulation of acute inflammatory response inflammatory response acute inflammatory response positive regulation of DNA-binding transcription factor activity regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of molecular function organic cyclic compound metabolic process regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process regulation of neuroinflammatory response neuroinflammatory response positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process regulation of peptidyl-serine phosphorylation positive regulation of cellular metabolic process positive regulation of phosphate metabolic process peptidyl-serine modification positive regulation of metabolic process positive regulation of protein modification process peptidyl-serine phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process positive regulation of cellular process organonitrogen compound metabolic process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process positive regulation of peptidyl-serine phosphorylation macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation positive regulation of epithelial cell apoptotic process positive regulation of programmed cell death regulation of epithelial cell apoptotic process regulation of type B pancreatic cell apoptotic process regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process epithelial cell apoptotic process positive regulation of type B pancreatic cell apoptotic process type B pancreatic cell apoptotic process apoptotic process programmed cell death negative regulation of biological process negative regulation of chemokine production negative regulation of cellular metabolic process regulation of cytokine production cytokine production negative regulation of cellular process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of cytokine production regulation of chemokine production negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process chemokine production negative regulation of multicellular organismal process regulation of body fluid levels wound healing cell activation hemostasis blood coagulation coagulation regulation of biological quality response to wounding platelet activation positive regulation of interleukin-8 production positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process interleukin-8 production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of cytokine production positive regulation of cellular biosynthetic process regulation of interleukin-8 production positive regulation of chemokine production cellular response to stimulus response to organic substance negative regulation of signaling signaling response to cytokine regulation of signal transduction negative regulation of cell communication cytokine-mediated signaling pathway cell communication negative regulation of interleukin-1-mediated signaling pathway cellular response to cytokine stimulus signal transduction cellular response to organic substance regulation of interleukin-1-mediated signaling pathway regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus regulation of cytokine-mediated signaling pathway negative regulation of signal transduction cellular response to interleukin-1 regulation of response to cytokine stimulus cellular response to chemical stimulus negative regulation of response to cytokine stimulus negative regulation of cytokine-mediated signaling pathway response to chemical interleukin-1-mediated signaling pathway regulation of cell communication response to interleukin-1 interleukin-10 production regulation of interleukin-10 production positive regulation of interleukin-10 production cell population proliferation regulation of smooth muscle cell proliferation positive regulation of cell population proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation biological process involved in interspecies interaction between organisms response to other organism defense response to Gram-negative bacterium response to biotic stimulus defense response to bacterium defense response to other organism response to bacterium response to external biotic stimulus inflammatory response to wounding regulation of leukocyte activation regulation of cell activation lymphocyte activation leukocyte activation positive regulation of lymphocyte activation positive regulation of cell activation regulation of B cell activation positive regulation of leukocyte activation regulation of immune system process positive regulation of immune system process B cell activation positive regulation of B cell activation immune system process regulation of lymphocyte activation cellular developmental process cell development regulation of cell differentiation regulation of neurogenesis regulation of cell development regulation of nervous system development negative regulation of neurogenesis neurogenesis cell differentiation negative regulation of nervous system development negative regulation of cell differentiation negative regulation of developmental process nervous system development negative regulation of cell development T cell activation lymphocyte proliferation regulation of leukocyte proliferation positive regulation of T cell activation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation mononuclear cell proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation positive regulation of leukocyte cell-cell adhesion leukocyte proliferation leukocyte cell-cell adhesion positive regulation of cell-cell adhesion cell adhesion cell-cell adhesion positive regulation of mononuclear cell proliferation regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation regulation of T cell proliferation regulation of mononuclear cell proliferation cellular homeostasis neuron cellular homeostasis homeostatic process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of immune effector process lymphocyte mediated immunity T cell mediated immunity positive regulation of leukocyte mediated immunity T-helper 2 cell cytokine production T cell cytokine production type 2 immune response positive regulation of immune response regulation of T-helper 2 cell cytokine production regulation of type 2 immune response leukocyte mediated immunity positive regulation of adaptive immune response positive regulation of T cell cytokine production regulation of T cell mediated immunity regulation of cytokine production involved in immune response positive regulation of T-helper 2 cell cytokine production immune response regulation of adaptive immune response immune effector process regulation of leukocyte mediated immunity regulation of immune response positive regulation of production of molecular mediator of immune response regulation of production of molecular mediator of immune response positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity regulation of T cell cytokine production CD4-positive, alpha-beta T cell cytokine production regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of immune effector process cytokine production involved in immune response production of molecular mediator of immune response adaptive immune response positive regulation of type 2 immune response regulation of lymphocyte mediated immunity positive regulation of T cell mediated immunity positive regulation of cytokine production involved in immune response fat cell differentiation negative regulation of fat cell differentiation regulation of fat cell differentiation neutrophil mediated immunity myeloid leukocyte mediated immunity positive regulation of cell communication cell surface receptor signaling pathway via STAT positive regulation of signal transduction positive regulation of receptor signaling pathway via STAT regulation of receptor signaling pathway via STAT positive regulation of signaling negative regulation of programmed cell death negative regulation of apoptotic process regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition mesenchyme development positive regulation of developmental process positive regulation of cell differentiation animal organ development tissue development epithelial to mesenchymal transition mesenchymal cell differentiation response to activity gland development animal organ regeneration liver development regeneration hepaticobiliary system development liver regeneration catabolic process macromolecule catabolic process regulation of DNA catabolic process cellular component organization execution phase of apoptosis positive regulation of DNA catabolic process DNA catabolic process apoptotic nuclear changes cellular component organization or biogenesis regulation of apoptotic DNA fragmentation cellular component disassembly positive regulation of nucleobase-containing compound metabolic process positive regulation of apoptotic DNA fragmentation DNA metabolic process regulation of catabolic process organic cyclic compound catabolic process nucleobase-containing compound catabolic process positive regulation of catabolic process apoptotic DNA fragmentation positive regulation of DNA metabolic process cellular component disassembly involved in execution phase of apoptosis nucleic acid catabolic process organic substance catabolic process regulation of DNA metabolic process interleukin-6-mediated signaling pathway response to interleukin-6 cellular response to interleukin-6 germinal center B cell differentiation mononuclear cell differentiation mature B cell differentiation B cell activation involved in immune response cell activation involved in immune response lymphocyte differentiation B cell differentiation leukocyte activation involved in immune response lymphocyte activation involved in immune response mature B cell differentiation involved in immune response hemopoiesis leukocyte differentiation interleukin-17 production regulation of interleukin-17 production positive regulation of interleukin-17 production maintenance of blood-brain barrier multicellular organismal-level homeostasis anatomical structure homeostasis tissue homeostasis regulation of cytokine production involved in inflammatory response production of molecular mediator involved in inflammatory response cytokine production involved in inflammatory response positive regulation of cytokine production involved in inflammatory response positive regulation of nervous system development regulation of gliogenesis positive regulation of glial cell proliferation positive regulation of gliogenesis regulation of glial cell proliferation gliogenesis positive regulation of neurogenesis positive regulation of cell development glial cell proliferation regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production regulation of localization nitrogen compound transport regulation of hormone secretion regulation of peptide secretion transport glucagon secretion hormone secretion peptide secretion localization secretion by cell regulation of secretion by cell regulation of glucagon secretion amide transport signal release regulation of peptide hormone secretion secretion regulation of transport regulation of hormone levels organic substance transport regulation of peptide transport cell-cell signaling export from cell establishment of localization regulation of secretion peptide transport peptide hormone secretion hormone transport peptidyl-tyrosine modification positive regulation of peptidyl-tyrosine phosphorylation regulation of peptidyl-tyrosine phosphorylation peptidyl-tyrosine phosphorylation positive regulation of leukocyte adhesion to vascular endothelial cell regulation of leukocyte adhesion to vascular endothelial cell leukocyte adhesion to vascular endothelial cell negative regulation of collagen metabolic process collagen biosynthetic process regulation of collagen biosynthetic process regulation of collagen metabolic process negative regulation of collagen biosynthetic process collagen metabolic process myeloid cell apoptotic process leukocyte apoptotic process neutrophil homeostasis neutrophil apoptotic process leukocyte homeostasis inflammatory cell apoptotic process homeostasis of number of cells myeloid cell homeostasis lipid storage lipid localization negative regulation of lipid localization maintenance of location regulation of lipid storage regulation of lipid localization negative regulation of lipid storage macromolecule localization homotypic cell-cell adhesion regulation of homotypic cell-cell adhesion platelet aggregation regulation of platelet activation regulation of platelet aggregation positive regulation of homotypic cell-cell adhesion positive regulation of platelet aggregation interleukin-1 production regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production positive regulation of interleukin-1 production regulation of interleukin-1 production interleukin-1 beta production protein localization establishment of protein localization cellular macromolecule localization establishment of protein localization to extracellular region protein secretion regulation of protein secretion cellular localization regulation of protein localization protein localization to extracellular region regulation of establishment of protein localization regulation of protein transport protein transport regulation of cellular localization regulation of insulin secretion insulin secretion negative regulation of tissue remodeling negative regulation of bone remodeling regulation of bone remodeling regulation of tissue remodeling regulation of bone resorption bone resorption negative regulation of bone resorption tissue remodeling bone remodeling acute-phase response immunoglobulin production positive regulation of immunoglobulin production regulation of immunoglobulin production hepatic immune response organ or tissue specific immune response defense response to symbiont defense response to virus response to virus transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process positive regulation of locomotion regulation of cell motility positive regulation of chemotaxis positive regulation of cell migration taxis positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion cell chemotaxis chemotaxis regulation of leukocyte chemotaxis regulation of leukocyte migration positive regulation of leukocyte chemotaxis positive regulation of leukocyte migration regulation of chemotaxis leukocyte migration regulation of locomotion leukocyte chemotaxis chemical homeostasis glucose homeostasis carbohydrate homeostasis plasma membrane bounded cell projection organization cell projection organization neuron projection development generation of neurons neuron differentiation neuron development extracellular matrix disassembly regulation of cellular component organization positive regulation of cellular component organization positive regulation of extracellular matrix organization extracellular matrix organization positive regulation of extracellular matrix disassembly regulation of extracellular matrix organization regulation of extracellular matrix disassembly extracellular structure organization external encapsulating structure organization post-transcriptional regulation of gene expression negative regulation of nucleobase-containing compound metabolic process RNA processing regulation of miRNA processing primary miRNA processing miRNA-mediated post-transcriptional gene silencing negative regulation of miRNA-mediated gene silencing post-transcriptional gene silencing miRNA processing negative regulation of post-transcriptional gene silencing negative regulation of RNA metabolic process negative regulation of primary miRNA processing regulation of miRNA-mediated gene silencing negative regulation of post-transcriptional gene silencing by regulatory ncRNA regulation of regulatory ncRNA processing regulation of gene silencing by regulatory ncRNA regulation of post-transcriptional gene silencing by regulatory ncRNA negative regulation of miRNA processing regulation of primary miRNA processing negative regulation of gene silencing by regulatory ncRNA regulatory ncRNA-mediated post-transcriptional gene silencing regulatory ncRNA processing regulatory ncRNA-mediated gene silencing regulation of post-transcriptional gene silencing regulation of vascular endothelial growth factor production vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production humoral immune response interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production regulation of macrophage activation myeloid leukocyte activation macrophage activation leukocyte activation involved in inflammatory response microglial cell activation regulation of microglial cell activation glial cell activation response to lipid cellular response to lipopolysaccharide response to oxygen-containing compound cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound cellular response to biotic stimulus cellular response to lipid response to molecule of bacterial origin response to corticosteroid response to hormone response to steroid hormone response to endogenous stimulus response to glucocorticoid response to organic cyclic compound epithelial cell proliferation involved in liver morphogenesis gland morphogenesis hepatocyte proliferation animal organ morphogenesis epithelial cell proliferation liver morphogenesis organonitrogen compound biosynthetic process positive regulation of translation translation regulation of translation cellular response to oxidative stress cellular response to chemical stress cellular response to hydrogen peroxide response to reactive oxygen species response to inorganic substance response to hydrogen peroxide response to oxidative stress cellular response to reactive oxygen species cellular response to stress pancreas development endocrine system development endocrine pancreas development intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade MAPK cascade monocyte chemotaxis mononuclear cell migration myeloid leukocyte migration negative regulation of cell population proliferation regulation of osteoblast differentiation osteoblast differentiation positive regulation of osteoblast differentiation ossification tyrosine phosphorylation of STAT protein regulation of tyrosine phosphorylation of STAT protein positive regulation of tyrosine phosphorylation of STAT protein cell surface receptor signaling pathway via JAK-STAT positive regulation of receptor signaling pathway via JAK-STAT regulation of receptor signaling pathway via JAK-STAT interleukin-21 production positive regulation of interleukin-21 production regulation of interleukin-21 production CD4-positive, alpha-beta T cell differentiation CD4-positive, alpha-beta T cell differentiation involved in immune response alpha-beta T cell differentiation involved in immune response alpha-beta T cell differentiation T cell activation involved in immune response alpha-beta T cell activation involved in immune response CD4-positive, alpha-beta T cell activation alpha-beta T cell activation T follicular helper cell differentiation T cell differentiation T-helper cell differentiation T cell differentiation involved in immune response positive regulation of neuroinflammatory response response to organonitrogen compound response to nitrogen compound response to peptidoglycan astrocyte differentiation astrocyte activation glial cell development regulation of astrocyte differentiation astrocyte development regulation of glial cell differentiation central nervous system development regulation of astrocyte activation glial cell differentiation cellular response to virus defense response to Gram-positive bacterium CD4-positive or CD8-positive, alpha-beta T cell lineage commitment CD4-positive, alpha-beta T cell lineage commitment alpha-beta T cell lineage commitment T-helper cell lineage commitment T cell lineage commitment T-helper 17 cell lineage commitment positive T cell selection T cell selection T-helper 17 cell differentiation cell fate commitment T-helper 17 type immune response	cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane plasma membrane signaling receptor complex membrane protein complex cellular anatomical entity interleukin-6 receptor complex receptor complex membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane plasma membrane signaling receptor complex membrane protein complex cellular anatomical entity interleukin-6 receptor complex receptor complex membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen organelle endoplasmic reticulum cytoplasm extracellular region extracellular space
C	Interleukin-6 receptor alpha chain	interleukin-11 receptor activity molecular transducer activity transmembrane signaling receptor activity signaling receptor activity cytokine receptor activity immune receptor activity ciliary neurotrophic factor binding protein binding binding cytokine binding interleukin-6 receptor activity interleukin-6 binding growth factor binding interleukin-11 binding interleukin-11 receptor activity molecular transducer activity transmembrane signaling receptor activity signaling receptor activity cytokine receptor activity immune receptor activity ciliary neurotrophic factor binding protein binding binding cytokine binding interleukin-6 receptor activity interleukin-6 binding growth factor binding interleukin-11 binding identical protein binding protein homodimerization activity protein dimerization activity enzyme binding	cellular response to stimulus response to organic substance regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to stimulus response to organic substance regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular process cellular response to organic substance signal transduction regulation of biosynthetic process negative regulation of collagen metabolic process negative regulation of metabolic process negative regulation of biological process collagen biosynthetic process regulation of collagen biosynthetic process regulation of collagen metabolic process negative regulation of collagen biosynthetic process biosynthetic process negative regulation of biosynthetic process metabolic process collagen metabolic process regulation of metabolic process cell death extrinsic apoptotic signaling pathway apoptotic signaling pathway apoptotic process programmed cell death positive regulation of cell communication positive regulation of signal transduction positive regulation of phosphorylation regulation of catalytic activity positive regulation of receptor signaling pathway via STAT regulation of signal transduction regulation of transferase activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process regulation of receptor signaling pathway via JAK-STAT positive regulation of macromolecule metabolic process protein modification process phosphorus metabolic process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation cellular metabolic process regulation of protein metabolic process primary metabolic process regulation of cellular metabolic process regulation of molecular function positive regulation of kinase activity regulation of kinase activity regulation of response to stimulus activation of protein kinase activity macromolecule modification positive regulation of activation of Janus kinase activity regulation of phosphorus metabolic process macromolecule metabolic process regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via STAT regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process positive regulation of cellular metabolic process peptidyl-tyrosine modification positive regulation of receptor signaling pathway via JAK-STAT regulation of activation of Janus kinase activity positive regulation of response to stimulus positive regulation of molecular function positive regulation of protein modification process positive regulation of peptidyl-tyrosine phosphorylation organic substance metabolic process protein metabolic process positive regulation of protein kinase activity positive regulation of cellular process activation of Janus kinase activity regulation of signaling organonitrogen compound metabolic process positive regulation of transferase activity regulation of peptidyl-tyrosine phosphorylation positive regulation of catalytic activity regulation of protein kinase activity regulation of macromolecule metabolic process regulation of cell communication regulation of phosphorylation peptidyl-tyrosine phosphorylation cell surface receptor signaling pathway via JAK-STAT positive regulation of signaling multicellular organismal process cellular biosynthetic process positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process regulation of cytokine production organic substance biosynthetic process cytokine production regulation of multicellular organismal process gene expression macromolecule biosynthetic process regulation of chemokine production regulation of cellular biosynthetic process regulation of gene expression positive regulation of gene expression chemokine production positive regulation of chemokine production positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process positive regulation of cytokine production positive regulation of cellular biosynthetic process acute-phase response defense response response to stress inflammatory response acute inflammatory response immune response immune system process hepatic immune response organ or tissue specific immune response cell population proliferation regulation of smooth muscle cell proliferation positive regulation of cell population proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation biological process involved in interspecies interaction between organisms response to other organism response to external stimulus defense response to Gram-negative bacterium response to biotic stimulus defense response to bacterium defense response to other organism response to bacterium response to external biotic stimulus negative regulation of cellular metabolic process negative regulation of interleukin-8 production negative regulation of cellular process negative regulation of macromolecule metabolic process negative regulation of cytokine production interleukin-8 production negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of macromolecule biosynthetic process negative regulation of multicellular organismal process regulation of interleukin-8 production positive regulation of locomotion regulation of cell motility regulation of response to external stimulus positive regulation of chemotaxis positive regulation of cell migration positive regulation of response to external stimulus taxis positive regulation of cell motility regulation of cell migration cell migration regulation of immune system process cell motility positive regulation of immune system process locomotion cell chemotaxis chemotaxis regulation of leukocyte chemotaxis regulation of leukocyte migration positive regulation of leukocyte chemotaxis positive regulation of leukocyte migration regulation of chemotaxis leukocyte migration regulation of locomotion leukocyte chemotaxis vascular endothelial growth factor production neutrophil mediated immunity leukocyte mediated immunity myeloid leukocyte mediated immunity immune effector process connective tissue development renal system development kidney vasculature development multicellular organism development renal system vasculature development positive regulation of glomerular mesangial cell proliferation regulation of glomerular mesangial cell proliferation anatomical structure development nephron development system development blood vessel development positive regulation of cell proliferation involved in kidney development developmental process animal organ development cell proliferation involved in kidney development glomerular mesangium development tissue development regulation of cell proliferation involved in kidney development vasculature development circulatory system development glomerulus development glomerular mesangial cell proliferation glomerulus vasculature development kidney development interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production ciliary neurotrophic factor-mediated signaling pathway pancreas development endocrine system development endocrine pancreas development interleukin-6-mediated signaling pathway response to interleukin-6 cellular response to interleukin-6 intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade MAPK cascade monocyte chemotaxis mononuclear cell migration myeloid leukocyte migration regulation of osteoblast differentiation cellular developmental process regulation of developmental process regulation of cell differentiation osteoblast differentiation positive regulation of developmental process positive regulation of osteoblast differentiation ossification positive regulation of cell differentiation cell differentiation tyrosine phosphorylation of STAT protein regulation of tyrosine phosphorylation of STAT protein positive regulation of tyrosine phosphorylation of STAT protein defense response to Gram-positive bacterium CD4-positive or CD8-positive, alpha-beta T cell lineage commitment adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation cell activation involved in immune response CD4-positive, alpha-beta T cell differentiation CD4-positive, alpha-beta T cell differentiation involved in immune response alpha-beta T cell differentiation involved in immune response leukocyte activation alpha-beta T cell differentiation T cell activation involved in immune response alpha-beta T cell activation involved in immune response T cell activation CD4-positive, alpha-beta T cell activation leukocyte activation involved in immune response alpha-beta T cell activation T cell differentiation CD4-positive, alpha-beta T cell lineage commitment lymphocyte activation involved in immune response T-helper cell differentiation alpha-beta T cell lineage commitment hemopoiesis cell activation T-helper cell lineage commitment T cell differentiation involved in immune response T cell lineage commitment adaptive immune response T-helper 17 cell lineage commitment positive T cell selection T cell selection T-helper 17 cell differentiation cell fate commitment leukocyte differentiation T-helper 17 type immune response	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane protein-containing complex plasma membrane protein complex plasma membrane signaling receptor complex ciliary neurotrophic factor receptor complex membrane protein complex receptor complex interleukin-6 receptor complex cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane protein-containing complex plasma membrane protein complex plasma membrane signaling receptor complex ciliary neurotrophic factor receptor complex membrane protein complex receptor complex interleukin-6 receptor complex extracellular region extracellular space apical part of cell plasma membrane region apical plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR003529	Long hematopoietin receptor, Gp130 family 2, conserved site	Conserved Site
A	IPR010457	Immunoglobulin C2-set-like, ligand-binding	Domain
A	IPR015321	Type I cytokine receptor, cytokine-binding domain	Domain
A	IPR003961	Fibronectin type III	Domain
A	IPR036116	Fibronectin type III superfamily	Homologous Superfamily
B	IPR030473	Interleukin-6/GCSF/MGF, conserved site	Conserved Site
B	IPR009079	Four-helical cytokine-like, core	Homologous Superfamily
B	IPR003574	Interleukin-6-like	Family
B	IPR030474	Interleukin-6/GCSF/MGF	Family
C	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
C	IPR003530	Long hematopoietin receptor, soluble alpha chain, conserved site	Conserved Site
C	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
C	IPR013151	Immunoglobulin	Domain
C	IPR007110	Immunoglobulin-like domain	Domain
C	IPR003599	Immunoglobulin subtype	Domain
C	IPR003598	Immunoglobulin subtype 2	Domain
C	IPR015321	Type I cytokine receptor, cytokine-binding domain	Domain
C	IPR003961	Fibronectin type III	Domain
C	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P40189	rheumatoid arthritis ovarian cancer colorectal cancer allergic disease prostate cancer Mammary Neoplasms, Experimental sarcomatoid carcinoma middle cerebral artery infarction pneumonia carcinoma non-small cell lung carcinoma Gaucher disease invasive ductal breast carcinoma pancreatic intraductal papillary-mucinous carcinoma juvenile idiopathic arthritis rheumatoid arthritis ovarian cancer colorectal cancer allergic disease prostate cancer Mammary Neoplasms, Experimental sarcomatoid carcinoma middle cerebral artery infarction pneumonia carcinoma non-small cell lung carcinoma Gaucher disease invasive ductal breast carcinoma pancreatic intraductal papillary-mucinous carcinoma juvenile idiopathic arthritis pilocytic astrocytoma adenoma malignant colon neoplasm progressive supranuclear palsy psoriasis mammary neoplasms, animal common variable immunodeficiency myopathy Duchenne muscular dystrophy Emery-Dreifuss muscular dystrophy oligodendroglioma glioblastoma ovarian neoplasm ischemia reperfusion injury pancreatic intraductal papillary-mucinous neoplasm large cell medulloblastoma plasma cell myeloma lung cancer pneumonitis malignant ependymoma astrocytic tumor MALT lymphoma Castleman disease colorectal carcinoma temporal arteritis coronary artery disease ulcerative colitis dermatomyositis neuromyelitis optica ductal breast carcinoma in situ osteosarcoma pancreatic ductal adenocarcinoma juvenile dermatomyositis Pick disease lung carcinoma polycystic ovary syndrome malignant glioma cleft lip medulloblastoma spina bifida thrombocytopenia Crohn disease myocardial ischemia undifferentiated carcinoma Down syndrome
B	Pharos: P05231	juvenile idiopathic arthritis type 2 diabetes mellitus psoriasis brain ischemia middle cerebral artery infarction renal cell carcinoma arteriovenous malformations of the brain inflammatory bowel disease cardiomyopathy aseptic meningitis Crohn disease atherosclerosis autoimmune hepatitis malignant mesothelioma skin basal cell carcinoma juvenile idiopathic arthritis type 2 diabetes mellitus psoriasis brain ischemia middle cerebral artery infarction renal cell carcinoma arteriovenous malformations of the brain inflammatory bowel disease cardiomyopathy aseptic meningitis Crohn disease atherosclerosis autoimmune hepatitis malignant mesothelioma skin basal cell carcinoma hypertensive disorder obesity disorder glomerulonephritis squamous cell carcinoma metabolic syndrome X osteoporosis polymyositis B-cell chronic lymphocytic leukemia cholangiocarcinoma leishmaniasis Wilson disease hemolytic-uremic syndrome congestive heart failure rheumatoid arthritis Castleman disease pneumonia autoimmune disease peripheral neuropathy plasma cell myeloma hypercalcemia disease allergic disease cirrhosis of liver breast carcinoma collecting duct carcinoma inborn mitochondrial myopathy visceral leishmaniasis Heat Stroke coronary artery disease pleural disease myocardial infarction schizophrenia Parkinson disease thyroid adenoma cerebrovascular disorder HIV wasting syndrome neurodegenerative disease nicotine dependence bipolar disorder chronic beryllium disease dissociative amnesia pulmonary fibrosis visual epilepsy congenital diaphragmatic hernia pleurisy intrahepatic cholangiocarcinoma secondary hyperparathyroidism extrahepatic cholestasis peripheral nervous system disease chromophobe renal cell carcinoma alcoholic liver cirrhosis tuberculosis skin disease chronic kidney disease prostate cancer chronic obstructive pulmonary disease melancholia breast cancer colitis endogenous depression sarcomatoid renal cell carcinoma papillary renal cell carcinoma myocarditis acute coronary syndrome thyroid gland carcinoma postmenopausal osteoporosis cholestasis Kaposi's sarcoma type 1 diabetes mellitus disseminated intravascular coagulation pulmonary edema leukopenia idiopathic interstitial pneumonia vertebral column disease pustulosis palmaris et plantaris heart disease synovitis anxiety disorder drug-induced liver injury burn systemic-onset juvenile idiopathic arthritis lung benign neoplasm Takayasu arteritis myeloid neoplasm inherited lipid metabolism disorder pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia thrombocytopenia lymphatic system disease acquired metabolic disease pneumonitis peripheral arterial disease major depressive disorder acute kidney failure autism peritonitis adult acute respiratory distress syndrome precancerous condition gastric cancer plasma cell neoplasm chorioamnionitis hyperglycemia kidney disease dermatitis, atopic primary hyperoxaluria skin pigmented basal cell carcinoma hypotensive disorder vasculitis clear cell renal carcinoma ileocolitis breast disease liver disease heart failure systemic lupus erythematosus colonic disease aortic stenosis infectious meningitis ovarian cancer inflammatory bowel disease 1 encephalitis pancreatic intraductal papillary-mucinous carcinoma cancer lung cancer hepatitis B virus infection interstitial cystitis pancreatitis hepatocellular carcinoma thrombotic disease COVID-19 myocardial ischemia asthma periodontitis lymphoplasmacytic lymphoma hereditary diffuse gastric adenocarcinoma thyroid cancer Crohn's colitis myopathy ischemia reperfusion injury malaria cystic fibrosis pituitary cancer delirium Kaposi sarcoma, susceptibility to gastric neoplasm depressive disorder non-small cell lung carcinoma bone marrow disease maturity-onset diabetes of the young ulcerative colitis diarrheal disease brain injury sleep-wake disorder amnestic disorder oral submucous fibrosis anemia inborn carbohydrate metabolic disorder renal carcinoma arteriosclerosis disorder ovarian neoplasm lung adenocarcinoma mood disorder arthritic joint disease influenza pancreatic intraductal papillary-mucinous neoplasm lung carcinoma injury interstitial lung disease invasive ductal breast carcinoma lymphoproliferative syndrome HIV infectious disease atopic eczema ischemic disease eye disease malignant ependymoma severe acute respiratory syndrome toxic encephalopathy dementia prediabetes syndrome neurotic disorder non-alcoholic fatty liver disease bile duct cancer skin epithelioid hemangioma Alzheimer disease prostate disease
C	Pharos: P08887	rheumatoid arthritis non-small cell lung carcinoma renal cell carcinoma juvenile idiopathic arthritis chromophobe renal cell carcinoma schizophrenia osteoporosis ankylosing spondylitis papillary renal cell carcinoma collecting duct carcinoma sarcomatoid renal cell carcinoma Still's disease tuberculosis lung carcinoma myocardial infarction rheumatoid arthritis non-small cell lung carcinoma renal cell carcinoma juvenile idiopathic arthritis chromophobe renal cell carcinoma schizophrenia osteoporosis ankylosing spondylitis papillary renal cell carcinoma collecting duct carcinoma sarcomatoid renal cell carcinoma Still's disease tuberculosis lung carcinoma myocardial infarction abdominal aortic aneurysm atopic eczema pancreatic ductal adenocarcinoma breast cancer Pick disease gastric cancer hereditary diffuse gastric adenocarcinoma subependymal giant cell astrocytoma large cell medulloblastoma ulcerative colitis malignant colon neoplasm medulloblastoma myopathy allergic rhinitis osteosarcoma atrial fibrillation pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia carpal tunnel syndrome pilocytic astrocytoma clear cell renal carcinoma gastric neoplasm Sjogren syndrome invasive ductal breast carcinoma temporal arteritis lung cancer malignant mesothelioma neuromyelitis optica ovarian cancer atypical teratoid rhabdoid tumor Castleman disease pituitary cancer renal carcinoma depressive disorder glioblastoma