1P3H

Crystal Structure of the Mycobacterium tuberculosis chaperonin 10 tetradecamer

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1p3ha_	All beta proteins	GroES-like	GroES-like	GroES	Chaperonin-10 (GroES)	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
B	d1p3hb_	All beta proteins	GroES-like	GroES-like	GroES	Chaperonin-10 (GroES)	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
C	d1p3hc_	All beta proteins	GroES-like	GroES-like	GroES	Chaperonin-10 (GroES)	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
D	d1p3hd_	All beta proteins	GroES-like	GroES-like	GroES	Chaperonin-10 (GroES)	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
E	d1p3he_	All beta proteins	GroES-like	GroES-like	GroES	Chaperonin-10 (GroES)	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
F	d1p3hf_	All beta proteins	GroES-like	GroES-like	GroES	Chaperonin-10 (GroES)	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
G	d1p3hg_	All beta proteins	GroES-like	GroES-like	GroES	Chaperonin-10 (GroES)	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
H	d1p3hh_	All beta proteins	GroES-like	GroES-like	GroES	Chaperonin-10 (GroES)	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
I	d1p3hi_	All beta proteins	GroES-like	GroES-like	GroES	Chaperonin-10 (GroES)	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
J	d1p3hj_	All beta proteins	GroES-like	GroES-like	GroES	Chaperonin-10 (GroES)	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
K	d1p3hk_	All beta proteins	GroES-like	GroES-like	GroES	Chaperonin-10 (GroES)	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
L	d1p3hl_	All beta proteins	GroES-like	GroES-like	GroES	Chaperonin-10 (GroES)	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
M	d1p3hm_	All beta proteins	GroES-like	GroES-like	GroES	Chaperonin-10 (GroES)	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
N	d1p3hn_	All beta proteins	GroES-like	GroES-like	GroES	Chaperonin-10 (GroES)	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	GroES chaperonin-like	8056974	4000251	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	GroES-like	8056975	3000002	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	GroES-like	8056975	3000002	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	GroES-like	8056975	3000002	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	GroES-like	8056975	3000002	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	GroES-like	8056975	3000002	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	GroES-like	8056975	3000002	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	GroES-like	8056975	3000002	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	GroES-like	8056975	3000002	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	GroES-like	8056975	3000002	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	GroES-like	8056975	3000002	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	GroES-like	8056975	3000002	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	GroES-like	8056975	3000002	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	GroES-like	8056975	3000002	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	GroES-like	8056975	3000002	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Cpn10	e1p3hA1	A: beta barrels	X: GroES-like	H: GroES-related	T: GroES	F: Cpn10	ECOD (1.6)
B	Cpn10	e1p3hB1	A: beta barrels	X: GroES-like	H: GroES-related	T: GroES	F: Cpn10	ECOD (1.6)
C	Cpn10	e1p3hC1	A: beta barrels	X: GroES-like	H: GroES-related	T: GroES	F: Cpn10	ECOD (1.6)
D	Cpn10	e1p3hD1	A: beta barrels	X: GroES-like	H: GroES-related	T: GroES	F: Cpn10	ECOD (1.6)
E	Cpn10	e1p3hE1	A: beta barrels	X: GroES-like	H: GroES-related	T: GroES	F: Cpn10	ECOD (1.6)
F	Cpn10	e1p3hF1	A: beta barrels	X: GroES-like	H: GroES-related	T: GroES	F: Cpn10	ECOD (1.6)
G	Cpn10	e1p3hG1	A: beta barrels	X: GroES-like	H: GroES-related	T: GroES	F: Cpn10	ECOD (1.6)
H	Cpn10	e1p3hH1	A: beta barrels	X: GroES-like	H: GroES-related	T: GroES	F: Cpn10	ECOD (1.6)
I	Cpn10	e1p3hI1	A: beta barrels	X: GroES-like	H: GroES-related	T: GroES	F: Cpn10	ECOD (1.6)
J	Cpn10	e1p3hJ1	A: beta barrels	X: GroES-like	H: GroES-related	T: GroES	F: Cpn10	ECOD (1.6)
K	Cpn10	e1p3hK1	A: beta barrels	X: GroES-like	H: GroES-related	T: GroES	F: Cpn10	ECOD (1.6)
L	Cpn10	e1p3hL1	A: beta barrels	X: GroES-like	H: GroES-related	T: GroES	F: Cpn10	ECOD (1.6)
M	Cpn10	e1p3hM1	A: beta barrels	X: GroES-like	H: GroES-related	T: GroES	F: Cpn10	ECOD (1.6)
N	Cpn10	e1p3hN1	A: beta barrels	X: GroES-like	H: GroES-related	T: GroES	F: Cpn10	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.33.40	Mainly Beta	Roll	10 Kd Chaperonin, Protein Cpn10	Chain O	CATH (4.3.0)
B	2.30.33.40	Mainly Beta	Roll	10 Kd Chaperonin, Protein Cpn10	Chain O	CATH (4.3.0)
C	2.30.33.40	Mainly Beta	Roll	10 Kd Chaperonin, Protein Cpn10	Chain O	CATH (4.3.0)
D	2.30.33.40	Mainly Beta	Roll	10 Kd Chaperonin, Protein Cpn10	Chain O	CATH (4.3.0)
E	2.30.33.40	Mainly Beta	Roll	10 Kd Chaperonin, Protein Cpn10	Chain O	CATH (4.3.0)
F	2.30.33.40	Mainly Beta	Roll	10 Kd Chaperonin, Protein Cpn10	Chain O	CATH (4.3.0)
G	2.30.33.40	Mainly Beta	Roll	10 Kd Chaperonin, Protein Cpn10	Chain O	CATH (4.3.0)
H	2.30.33.40	Mainly Beta	Roll	10 Kd Chaperonin, Protein Cpn10	Chain O	CATH (4.3.0)
I	2.30.33.40	Mainly Beta	Roll	10 Kd Chaperonin, Protein Cpn10	Chain O	CATH (4.3.0)
J	2.30.33.40	Mainly Beta	Roll	10 Kd Chaperonin, Protein Cpn10	Chain O	CATH (4.3.0)
K	2.30.33.40	Mainly Beta	Roll	10 Kd Chaperonin, Protein Cpn10	Chain O	CATH (4.3.0)
L	2.30.33.40	Mainly Beta	Roll	10 Kd Chaperonin, Protein Cpn10	Chain O	CATH (4.3.0)
M	2.30.33.40	Mainly Beta	Roll	10 Kd Chaperonin, Protein Cpn10	Chain O	CATH (4.3.0)
N	2.30.33.40	Mainly Beta	Roll	10 Kd Chaperonin, Protein Cpn10	Chain O	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	PF00166	Chaperonin 10 Kd subunit (Cpn10)	Chaperonin 10 Kd subunit	This family contains GroES and Gp31-like chaperonins. Gp31 is a functional co-chaperonin that is required for the folding and assembly of Gp23, a major capsid protein, during phage morphogenesis [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	10 kDa chaperonin	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding unfolded protein binding protein binding enzyme binding zymogen binding protein folding chaperone cation binding metal ion binding protein-folding chaperone binding	regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process organonitrogen compound metabolic process chaperone cofactor-dependent protein refolding chaperone-mediated protein folding protein maturation protein folding protein metabolic process 'de novo' protein folding 'de novo' post-translational protein folding response to stimulus response to chemical response to antibiotic cellular response to stimulus cellular response to heat cellular response to stress response to stress response to heat response to abiotic stimulus response to temperature stimulus	extracellular region cellular anatomical entity intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane external encapsulating structure cell wall peptidoglycan-based cell wall

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR018369	Chaperonin GroES, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR011032	GroES-like superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR037124	GroES chaperonin superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR020818	GroES chaperonin family	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.