1OW1

Crystal structure of the SPOC domain of the human transcriptional corepressor, SHARP.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ow1a_	All beta proteins	SPOC domain-like	SPOC domain-like	SPOC domain	SMART/HDAC1 associated repressor protein, SHARP	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	SPOC domain	8025450	4000914	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	SPOC domain-like	8037829	3000675	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF07744	e1ow1A1	A: beta barrels	X: SPOC domain-like	H: SPOC domain-related	T: SPOC domain	F: PF07744	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.290.10	Mainly Beta	Beta Barrel	Ku70	Chain: A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF07744	SPOC domain (SPOC)	SPOC domain	The SPOC (Spen paralogue and orthologue C-terminal) domain is involved in developmental signalling [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	SMART/HDAC1 associated repressor protein	transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding RNA binding organic cyclic compound binding nucleic acid binding DNA binding transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding RNA binding organic cyclic compound binding nucleic acid binding DNA binding transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity mRNA binding	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process positive regulation of nervous system development multicellular organismal process regulation of developmental process cellular developmental process positive regulation of biological process cell development regulation of cell differentiation regulation of neurogenesis regulation of cell development regulation of nervous system development positive regulation of developmental process multicellular organism development neurogenesis positive regulation of cell differentiation cell differentiation anatomical structure development positive regulation of neurogenesis regulation of multicellular organismal process positive regulation of cellular process system development developmental process regulation of multicellular organismal development positive regulation of cell development nervous system development positive regulation of multicellular organismal process transcription by RNA polymerase II regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling cell communication Notch signaling pathway signal transduction	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen protein-containing complex transcription regulator complex transcription repressor complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR016194	SPOC-like, C-terminal domain superfamily	Homologous Superfamily
A	IPR049093	Msx2-interacting protein, nuclear receptor-interacting domain	Domain
A	IPR012921	Spen paralogue and orthologue SPOC, C-terminal	Domain
A	IPR034175	SHARP, RNA recognition motif 4	Domain
A	IPR049094	Msx2-interacting protein, RAM7 domain	Domain
A	IPR010912	Spen paralogue/orthologue C-terminal, metazoa	Domain
A	IPR034173	SHARP, RNA recognition motif 2	Domain
A	IPR049095	Msx2-interacting protein, MID domain	Domain
A	IPR000504	RNA recognition motif domain	Domain
A	IPR034174	SHARP, RNA recognition motif 3	Domain
A	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
A	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
A	IPR034172	SHARP, RNA recognition motif 1	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q96T58	prostate cancer primitive neuroectodermal tumor Prostatic Neoplasms acute myeloid leukemia atypical teratoid rhabdoid tumor dilated cardiomyopathy large cell medulloblastoma malignant mesothelioma non-Hodgkin lymphoma ovarian carcinoma psoriasis subependymal giant cell astrocytoma Alzheimer disease breast carcinoma gastric carcinoma prostate cancer primitive neuroectodermal tumor Prostatic Neoplasms acute myeloid leukemia atypical teratoid rhabdoid tumor dilated cardiomyopathy large cell medulloblastoma malignant mesothelioma non-Hodgkin lymphoma ovarian carcinoma psoriasis subependymal giant cell astrocytoma Alzheimer disease breast carcinoma gastric carcinoma malignant ependymoma osteosarcoma Pick disease prostate carcinoma rheumatoid arthritis astrocytic tumor diffuse large B-cell lymphoma glioblastoma malignant glioma medulloblastoma ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.