Annotations: 1OSX

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1osxa_	Small proteins	TNF receptor-like	TNF receptor-like	BAFF receptor-like	Tumor necrosis factor receptor superfamily member 13c, BAFF-R, Br3	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF09256	e1osxA1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: PF09256	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF09256	BAFF-R, TALL-1 binding (BaffR-Tall_bind)	BAFF-R, TALL-1 binding	Members of this family, which are predominantly found in the tumour necrosis factor receptor superfamily member 13c, BAFF-R, are required for binding to tumour necrosis factor ligand TALL-1 [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Tumor necrosis factor receptor superfamily member 13C	molecular transducer activity signaling receptor activity	multicellular organismal process regulation of cellular process regulation of leukocyte activation positive regulation of biological process regulation of cell activation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell activation cell adhesion cell-cell adhesion T cell activation multicellular organismal process regulation of cellular process regulation of leukocyte activation positive regulation of biological process regulation of cell activation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell activation cell adhesion cell-cell adhesion T cell activation positive regulation of leukocyte activation regulation of multicellular organismal process regulation of immune system process regulation of cell-cell adhesion positive regulation of immune system process positive regulation of cellular process regulation of biological process positive regulation of T cell activation positive regulation of cell adhesion regulation of cell adhesion cell activation biological regulation regulation of T cell activation immune system process lymphocyte costimulation regulation of leukocyte cell-cell adhesion positive regulation of multicellular organismal process cellular process T cell costimulation regulation of lymphocyte activation regulation of B cell activation B cell costimulation B cell activation positive regulation of B cell activation positive regulation of cell population proliferation positive regulation of B cell proliferation leukocyte proliferation regulation of B cell proliferation lymphocyte proliferation positive regulation of mononuclear cell proliferation regulation of lymphocyte proliferation regulation of leukocyte proliferation cell population proliferation positive regulation of lymphocyte proliferation B cell proliferation regulation of cell population proliferation mononuclear cell proliferation positive regulation of leukocyte proliferation regulation of mononuclear cell proliferation response to stimulus immune response adaptive immune response positive regulation of T cell proliferation T cell proliferation regulation of T cell proliferation cellular response to stimulus response to organic substance cell surface receptor signaling pathway signaling response to cytokine cytokine-mediated signaling pathway cell communication cellular response to chemical stimulus cellular response to tumor necrosis factor response to chemical tumor necrosis factor-mediated signaling pathway cellular response to cytokine stimulus cellular response to organic substance signal transduction response to tumor necrosis factor	cell periphery plasma membrane membrane cellular anatomical entity cell surface external side of plasma membrane side of membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR015336	Tumour necrosis factor receptor 13C, TALL-1 binding domain	Domain
A	IPR022338	Tumour necrosis factor receptor 13C	Family
A	IPR043521	Tumor necrosis factor receptor 13C/17	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q96RJ3	common variable immunodeficiency agammaglobulinemia Acquired Hypogammaglobulinemia immunodeficiency, common variable, 4 interstitial cystitis osteosarcoma tuberculosis medulloblastoma primitive neuroectodermal tumor ulcerative colitis B cell deficiency brain injury ductal breast carcinoma in situ nasopharyngeal carcinoma Sjogren syndrome

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.