1OQC

The crystal structure of augmenter of liver regeneration: a mammalian FAD dependent sulfhydryl oxidase

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1oqca_	All alpha proteins	Four-helical up-and-down bundle	FAD-dependent thiol oxidase	FAD-dependent thiol oxidase	Augmenter of liver regeneration	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B	d1oqcb_	All alpha proteins	Four-helical up-and-down bundle	FAD-dependent thiol oxidase	FAD-dependent thiol oxidase	Augmenter of liver regeneration	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
C	d1oqcc_	All alpha proteins	Four-helical up-and-down bundle	FAD-dependent thiol oxidase	FAD-dependent thiol oxidase	Augmenter of liver regeneration	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
D	d1oqcd_	All alpha proteins	Four-helical up-and-down bundle	FAD-dependent thiol oxidase	FAD-dependent thiol oxidase	Augmenter of liver regeneration	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	FAD-dependent thiol oxidase	8021857	4002787	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	FAD-dependent thiol oxidase	8034237	3001745	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	FAD-dependent thiol oxidase	8034237	3001745	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	FAD-dependent thiol oxidase	8034237	3001745	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	FAD-dependent thiol oxidase	8034237	3001745	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF04777	e1oqcA1	A: alpha bundles	X: Four-helical up-and-down bundle	H: FAD-dependent thiol oxidase (From Topology)	T: FAD-dependent thiol oxidase	F: PF04777	ECOD (1.6)
B	PF04777	e1oqcB1	A: alpha bundles	X: Four-helical up-and-down bundle	H: FAD-dependent thiol oxidase (From Topology)	T: FAD-dependent thiol oxidase	F: PF04777	ECOD (1.6)
C	PF04777	e1oqcC1	A: alpha bundles	X: Four-helical up-and-down bundle	H: FAD-dependent thiol oxidase (From Topology)	T: FAD-dependent thiol oxidase	F: PF04777	ECOD (1.6)
D	PF04777	e1oqcD1	A: alpha bundles	X: Four-helical up-and-down bundle	H: FAD-dependent thiol oxidase (From Topology)	T: FAD-dependent thiol oxidase	F: PF04777	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.120.310	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	ERV/ALR sulfhydryl oxidase domain	CATH (4.3.0)
B	1.20.120.310	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	ERV/ALR sulfhydryl oxidase domain	CATH (4.3.0)
C	1.20.120.310	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	ERV/ALR sulfhydryl oxidase domain	CATH (4.3.0)
D	1.20.120.310	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	ERV/ALR sulfhydryl oxidase domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF04777	Erv1 / Alr family (Evr1_Alr)	Erv1 / Alr family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	augmenter of liver regeneration	protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity oxidoreductase activity, acting on a sulfur group of donors disulfide oxidoreductase activity oxidoreductase activity catalytic activity, acting on a protein protein-disulfide reductase activity protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity oxidoreductase activity, acting on a sulfur group of donors disulfide oxidoreductase activity oxidoreductase activity catalytic activity, acting on a protein protein-disulfide reductase activity catalytic activity flavin adenine dinucleotide binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor flavin-dependent sulfhydryl oxidase activity thiol oxidase activity	developmental process multicellular organism development multicellular organismal process hepaticobiliary system development gland development animal organ development anatomical structure development liver development system development cellular response to stimulus response to organic substance response to stimulus response to cytokine cellular response to chemical stimulus developmental process multicellular organism development multicellular organismal process hepaticobiliary system development gland development animal organ development anatomical structure development liver development system development cellular response to stimulus response to organic substance response to stimulus response to cytokine cellular response to chemical stimulus cellular response to tumor necrosis factor response to chemical cellular response to cytokine stimulus cellular process cellular response to organic substance response to tumor necrosis factor cellular response to nitrogen compound response to organonitrogen compound response to endogenous stimulus response to oxygen-containing compound response to actinomycin D response to nitrogen compound response to antibiotic cellular response to oxygen-containing compound cellular response to actinomycin D cellular response to antibiotic cellular response to endogenous stimulus cellular response to organonitrogen compound cellular response to toxic substance response to toxic substance regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process regulation of DNA biosynthetic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process nucleic acid biosynthetic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process positive regulation of DNA biosynthetic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process DNA metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process positive regulation of DNA metabolic process biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process DNA biosynthetic process positive regulation of cellular biosynthetic process regulation of DNA metabolic process biological process involved in interspecies interaction between organisms response to lipid response to other organism cellular response to lipopolysaccharide response to external stimulus cellular response to molecule of bacterial origin response to lipopolysaccharide response to biotic stimulus cellular response to biotic stimulus response to bacterium cellular response to lipid response to external biotic stimulus response to molecule of bacterial origin animal organ regeneration regeneration liver regeneration regulation of immune effector process lymphocyte mediated immunity negative regulation of lymphocyte mediated immunity negative regulation of natural killer cell mediated immunity leukocyte mediated immunity regulation of immune system process natural killer cell mediated immunity regulation of natural killer cell mediated immunity immune response regulation of innate immune response negative regulation of immune response negative regulation of immune effector process leukocyte mediated cytotoxicity immune effector process regulation of leukocyte mediated immunity regulation of response to stimulus defense response to other organism negative regulation of response to external stimulus negative regulation of defense response natural killer cell mediated cytotoxicity regulation of immune response regulation of cell killing negative regulation of natural killer cell mediated cytotoxicity regulation of defense response regulation of response to biotic stimulus regulation of natural killer cell mediated cytotoxicity regulation of response to external stimulus negative regulation of response to biotic stimulus response to stress regulation of response to stress negative regulation of leukocyte mediated cytotoxicity innate immune response negative regulation of cell killing defense response negative regulation of response to stimulus regulation of leukocyte mediated cytotoxicity defense response to symbiont regulation of lymphocyte mediated immunity negative regulation of immune system process immune system process negative regulation of leukocyte mediated immunity cell killing negative regulation of innate immune response	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol extracellular region extracellular space mitochondrial intermembrane space membrane-enclosed lumen intracellular organelle lumen membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol extracellular region extracellular space mitochondrial intermembrane space membrane-enclosed lumen intracellular organelle lumen organelle envelope lumen organelle envelope organelle lumen mitochondrial envelope

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR036774	ERV/ALR sulfhydryl oxidase domain superfamily	Homologous Superfamily
A, B, C, D	IPR017905	ERV/ALR sulfhydryl oxidase domain	Domain
A, B, C, D	IPR039799	Sulfhydryl oxidase ALR/ERV	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.