1OJ5

Crystal structure of the Nco-A1 PAS-B domain bound to the STAT6 transactivation domain LXXLL motif

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1oj5a_	Alpha and beta proteins (a+b)	Profilin-like	PYP-like sensor domain (PAS domain)	PAS domain of steroid receptor coactivator 1A, NCo-A1	PAS domain of steroid receptor coactivator 1A, NCo-A1	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	PAS domain of steroid receptor coactivator 1A NCo-A1	8025138	4001545	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PYP-like sensor domain (PAS domain)	8037517	3000471	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PAS_11	e1oj5A1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: PAS_11	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.450.20	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	PAS domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF14598	PAS domain (PAS_11)	PAS domain	This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6) [1].	Domain
B	PF14596	STAT6 C-terminal (STAT6_C)	STAT6 C-terminal	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	STEROID RECEPTOR COACTIVATOR 1A	DNA binding binding organic cyclic compound binding nucleic acid binding protein-containing complex binding transcription coactivator activity transcription regulator activity transcription coregulator activity nuclear receptor coactivator activity protein-macromolecule adaptor activity molecular adaptor activity protein binding protein dimerization activity catalytic activity, acting on a protein DNA binding binding organic cyclic compound binding nucleic acid binding protein-containing complex binding transcription coactivator activity transcription regulator activity transcription coregulator activity nuclear receptor coactivator activity protein-macromolecule adaptor activity molecular adaptor activity protein binding protein dimerization activity catalytic activity, acting on a protein N-acetyltransferase activity acyltransferase activity transferase activity peptide N-acetyltransferase activity histone acetyltransferase activity acetyltransferase activity peptide-lysine-N-acetyltransferase activity histone modifying activity acyltransferase activity, transferring groups other than amino-acyl groups catalytic activity N-acyltransferase activity chromatin binding transcription factor binding nuclear retinoic acid receptor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding DNA-binding transcription factor binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription regulatory region nucleic acid binding nuclear retinoid X receptor binding nuclear estrogen receptor binding	developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development system development placenta development chordate embryonic development embryonic morphogenesis labyrinthine layer development embryo development in utero embryonic development embryonic placenta morphogenesis labyrinthine layer morphogenesis anatomical structure morphogenesis embryonic placenta development embryo development ending in birth or egg hatching embryonic organ development ovulation cycle rhythmic process estrous cycle multicellular organismal reproductive process response to organic substance response to ketone response to lipid response to stimulus response to endogenous stimulus response to progesterone response to oxygen-containing compound response to hormone response to steroid hormone response to chemical response to organic cyclic compound regulation of biological process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process biological regulation positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process cellular process apoptotic process programmed cell death positive regulation of cellular process head development brain development nervous system development cerebellum development central nervous system development metencephalon development hindbrain development behavior male mating behavior reproductive behavior mating behavior forebrain development pallium development cerebral cortex development telencephalon development cellular response to stimulus intracellular receptor signaling pathway signaling cell communication peroxisome proliferator activated receptor signaling pathway signal transduction mRNA transcription by RNA polymerase II cellular biosynthetic process RNA metabolic process mRNA transcription nucleobase-containing compound metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process organic substance metabolic process transcription by RNA polymerase II organic substance biosynthetic process cellular metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process organic cyclic compound biosynthetic process metabolic process macromolecule metabolic process regulation of body fluid levels secretion transport mammary gland development gland development establishment of localization body fluid secretion localization lactation regulation of biological quality cellular response to chemical stimulus response to Thyroglobulin triiodothyronine cellular response to Thyroglobulin triiodothyronine cellular response to nitrogen compound response to peptide hormone regulation of cellular response to insulin stimulus cellular response to endogenous stimulus cellular response to organic substance cellular response to hormone stimulus response to organonitrogen compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to organonitrogen compound regulation of response to stimulus response to insulin cellular response to insulin stimulus positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process hippocampus development limbic system development regulation of transcription from RNA polymerase II promoter by galactose carbon catabolite regulation of transcription positive regulation of transcription by galactose cellular response to nutrient levels carbon catabolite regulation of transcription from RNA polymerase II promoter carbon catabolite activation of transcription from RNA polymerase II promoter carbon catabolite activation of transcription response to nutrient levels regulation of transcription by galactose response to nutrient positive regulation of transcription from RNA polymerase II promoter by galactose cellular response to nutrient regulation of developmental process connective tissue development adipose tissue development positive regulation of adipose tissue development tissue development positive regulation of developmental process regulation of adipose tissue development positive regulation of multicellular organismal process regulation of multicellular organismal process hypothalamus development diencephalon development response to retinoic acid cellular developmental process regulation of cell differentiation positive regulation of neuron differentiation neurogenesis neuron differentiation positive regulation of cell differentiation cell differentiation generation of neurons regulation of neuron differentiation thyroid hormone mediated signaling pathway regulation of signal transduction hormone-mediated signaling pathway regulation of thyroid hormone mediated signaling pathway regulation of signaling regulation of cell communication positive regulation of female receptivity female mating behavior regulation of female receptivity response to estradiol	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex transcription regulator complex intracellular organelle protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle RNA polymerase II transcription regulator complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex transcription regulator complex intracellular organelle protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle RNA polymerase II transcription regulator complex membrane-bounded organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cell periphery plasma membrane membrane membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
B	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6	DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription regulator activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription regulator activity DNA-binding transcription factor activity protein phosphatase binding phosphatase binding protein binding enzyme binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription factor binding transcription coregulator binding transcription coactivator binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity identical protein binding	cellular response to stimulus cellular response to nitrogen compound response to organic substance regulation of cellular process response to stimulus signaling response to peptide hormone cellular response to growth hormone stimulus cell surface receptor protein tyrosine kinase signaling pathway cell communication cellular response to endogenous stimulus response to hormone growth hormone receptor signaling pathway via JAK-STAT signal transduction cellular response to stimulus cellular response to nitrogen compound response to organic substance regulation of cellular process response to stimulus signaling response to peptide hormone cellular response to growth hormone stimulus cell surface receptor protein tyrosine kinase signaling pathway cell communication cellular response to endogenous stimulus response to hormone growth hormone receptor signaling pathway via JAK-STAT signal transduction cellular response to organic substance enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus regulation of biological process growth hormone receptor signaling pathway cell surface receptor signaling pathway response to endogenous stimulus response to organonitrogen compound biological regulation cellular response to peptide hormone stimulus response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound response to growth hormone cellular response to chemical stimulus cellular response to organonitrogen compound response to chemical cellular process response to cytokine cytokine-mediated signaling pathway cellular response to cytokine stimulus regulation of leukocyte proliferation regulation of mast cell proliferation cell population proliferation regulation of cell population proliferation leukocyte proliferation mast cell proliferation immune response negative regulation of response to stimulus negative regulation of immune response negative regulation of biological process negative regulation of type 2 immune response type 2 immune response regulation of response to stimulus negative regulation of immune system process immune system process regulation of type 2 immune response regulation of immune response regulation of immune system process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of leukocyte activation regulation of cell activation B cell activation involved in immune response positive regulation of macromolecule biosynthetic process regulation of primary metabolic process multicellular organism development positive regulation of immune response organic substance biosynthetic process positive regulation of macromolecule metabolic process system development positive regulation of DNA recombination positive regulation of immunoglobulin mediated immune response DNA recombination cellular metabolic process primary metabolic process DNA metabolic process immune effector process regulation of gene expression biosynthetic process positive regulation of DNA metabolic process B cell mediated immunity positive regulation of production of molecular mediator of immune response metabolic process regulation of macromolecule biosynthetic process regulation of DNA metabolic process immunoglobulin production regulation of developmental process positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains somatic cell DNA recombination positive regulation of cellular metabolic process somatic diversification of immunoglobulins involved in immune response positive regulation of lymphocyte activation somatic recombination of immunoglobulin gene segments positive regulation of biosynthetic process regulation of immunoglobulin mediated immune response leukocyte activation involved in immune response positive regulation of isotype switching regulation of B cell activation positive regulation of immune effector process positive regulation of cellular process production of molecular mediator of immune response positive regulation of immunoglobulin production regulation of isotype switching cell activation regulation of macromolecule metabolic process macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of gene expression somatic diversification of immune receptors via germline recombination within a single locus positive regulation of cellular biosynthetic process regulation of lymphocyte activation multicellular organismal process lymphocyte mediated immunity regulation of immune effector process regulation of DNA recombination positive regulation of leukocyte mediated immunity regulation of isotype switching to IgE isotypes cell activation involved in immune response nucleobase-containing compound metabolic process positive regulation of developmental process positive regulation of isotype switching to IgE isotypes positive regulation of cell activation positive regulation of metabolic process anatomical structure development positive regulation of leukocyte activation leukocyte mediated immunity somatic diversification of immune receptors regulation of nucleobase-containing compound metabolic process positive regulation of adaptive immune response positive regulation of immune system process somatic recombination of immunoglobulin genes involved in immune response developmental process positive regulation of nucleobase-containing compound metabolic process regulation of adaptive immune response regulation of cellular metabolic process regulation of B cell mediated immunity somatic diversification of immunoglobulins organic cyclic compound metabolic process regulation of leukocyte mediated immunity positive regulation of multicellular organismal process macromolecule metabolic process regulation of production of molecular mediator of immune response regulation of metabolic process isotype switching immune system development immunoglobulin production involved in immunoglobulin-mediated immune response positive regulation of lymphocyte mediated immunity cellular biosynthetic process positive regulation of biological process lymphocyte activation positive regulation of B cell mediated immunity leukocyte activation positive regulation of response to stimulus organic substance metabolic process regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of multicellular organismal process lymphocyte activation involved in immune response regulation of biosynthetic process isotype switching to IgE isotypes B cell activation gene expression immunoglobulin mediated immune response adaptive immune response positive regulation of B cell activation regulation of immunoglobulin production regulation of lymphocyte mediated immunity cellular response to reactive nitrogen species epithelium development mammary gland development gland development animal organ development tissue development mammary gland epithelium development epithelial cell proliferation mammary gland epithelial cell proliferation defense response response to stress cellular response to oxidative stress cellular response to chemical stress cellular response to hydrogen peroxide response to reactive oxygen species response to inorganic substance response to hydrogen peroxide response to oxidative stress cellular response to reactive oxygen species cellular response to stress interleukin-4-mediated signaling pathway response to interleukin-4 cellular response to interleukin-4 anatomical structure morphogenesis gland morphogenesis mammary gland morphogenesis animal organ morphogenesis homeostatic process adaptive thermogenesis multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis CD4-positive or CD8-positive, alpha-beta T cell lineage commitment cellular developmental process T-helper 1 cell lineage commitment cell development mononuclear cell differentiation lymphocyte differentiation CD4-positive, alpha-beta T cell differentiation CD4-positive, alpha-beta T cell differentiation involved in immune response alpha-beta T cell differentiation involved in immune response alpha-beta T cell differentiation T cell activation involved in immune response alpha-beta T cell activation involved in immune response T cell activation cell differentiation CD4-positive, alpha-beta T cell activation alpha-beta T cell activation T cell differentiation CD4-positive, alpha-beta T cell lineage commitment T-helper cell differentiation alpha-beta T cell lineage commitment hemopoiesis T cell differentiation involved in immune response T-helper 1 type immune response T-helper cell lineage commitment T cell lineage commitment positive T cell selection T-helper 1 cell differentiation T cell selection cell fate commitment leukocyte differentiation cell surface receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT RNA metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process	RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle cytoplasm cytosol membrane-enclosed lumen RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR010011	Nuclear receptor coactivator, DUF1518	Domain
A	IPR028819	Nuclear receptor coactivator 1, basic helix-loop-helix	Domain
A	IPR009110	Nuclear receptor coactivator, interlocking	Homologous Superfamily
A	IPR017426	Nuclear receptor coactivator	Family
A	IPR014935	Nuclear receptor coactivator, receptor-binding domain	Domain
A	IPR014920	Nuclear receptor coactivator, Ncoa-type, interlocking	Domain
A	IPR035965	PAS domain superfamily	Homologous Superfamily
A	IPR036638	Helix-loop-helix DNA-binding domain superfamily	Homologous Superfamily
A	IPR037077	Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily	Homologous Superfamily
A	IPR013767	PAS fold	Domain
A	IPR000014	PAS domain	Domain
A	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain	Domain
B	IPR035857	STAT6, SH2 domain	Domain
B	IPR048988	Signal transducer and activator of transcription, linker domain	Domain
B	IPR036535	STAT transcription factor, N-terminal domain superfamily	Homologous Superfamily
B	IPR013800	STAT transcription factor, all-alpha domain	Domain
B	IPR036860	SH2 domain superfamily	Homologous Superfamily
B	IPR000980	SH2 domain	Domain
B	IPR001217	Transcription factor STAT	Family
B	IPR008967	p53-like transcription factor, DNA-binding domain superfamily	Homologous Superfamily
B	IPR013799	STAT transcription factor, protein interaction	Domain
B	IPR015988	STAT transcription factor, coiled coil	Homologous Superfamily
B	IPR013801	STAT transcription factor, DNA-binding	Domain
B	IPR028187	STAT6, C-terminal	Domain
B	IPR012345	STAT transcription factor, DNA-binding, N-terminal	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: P42226	pulmonary fibrosis Edema head and neck cancer hemangiopericytoma asthma solitary fibrous tumor invasive ductal breast carcinoma lung cancer abdominal aortic aneurysm malignant tumor of neck osteosarcoma attention deficit hyperactivity disorder, inattentive type peripheral nervous system disease breast cancer chronic obstructive pulmonary disease pulmonary fibrosis Edema head and neck cancer hemangiopericytoma asthma solitary fibrous tumor invasive ductal breast carcinoma lung cancer abdominal aortic aneurysm malignant tumor of neck osteosarcoma attention deficit hyperactivity disorder, inattentive type peripheral nervous system disease breast cancer chronic obstructive pulmonary disease dermatitis, atopic juvenile dermatomyositis lung carcinoma allergic disease medulloblastoma ovarian cancer peripheral neuropathy atypical teratoid rhabdoid tumor cancer colorectal adenoma diffuse large B-cell lymphoma eosinophilic esophagitis head and neck neoplasm idiopathic interstitial pneumonia large cell medulloblastoma malignant mesothelioma allergic rhinitis neoplasm of neck atopic eczema pancreatic intraductal papillary-mucinous neoplasm psoriasis autism spectrum disorder subependymal giant cell astrocytoma colorectal cancer