Annotations: 1OIS

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1oisa_	Multi-domain proteins (alpha and beta)	Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Eukaryotic DNA topoisomerase I N-terminal DNA-binding domain-like	8025184	4002858	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Eukaryotic DNA topoisomerase I N-terminal DNA-binding domain-like	8037563	3001820	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02919	e1oisA1	A: beta complex topology	X: Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment (From Topology)	H: Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment (From Topology)	T: Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	F: PF02919	ECOD (1.6)
A	PF02919	e1oisA2	A: alpha arrays	X: Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment (From Topology)	H: Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment (From Topology)	T: Alpha-helical domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	F: PF02919	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.10.41	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Yeast DNA topoisomerase - domain 1	CATH (4.3.0)
A	2.170.11.10	Mainly Beta	Beta Complex	DNA Topoisomerase I	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02919	Eukaryotic DNA topoisomerase I, DNA binding fragment (Topoisom_I_N)	Eukaryotic DNA topoisomerase I, DNA binding fragment	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	DNA TOPOISOMERASE I	DNA binding binding organic cyclic compound binding nucleic acid binding isomerase activity DNA topoisomerase type I (single strand cut, ATP-independent) activity catalytic activity, acting on DNA DNA topoisomerase activity catalytic activity, acting on a nucleic acid catalytic activity	nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process cellular process cell cycle chromosome segregation cell cycle process establishment of organelle localization nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process cellular process cell cycle chromosome segregation cell cycle process establishment of organelle localization cellular localization transport nucleus localization intracellular transport establishment of localization localization organelle localization establishment of localization in cell nuclear migration mitotic nuclear division mitotic chromosome condensation organelle fission chromosome organization sister chromatid segregation mitotic cell cycle cellular component organization organelle organization nuclear division mitotic cell cycle process chromosome condensation mitotic sister chromatid segregation nuclear chromosome segregation cellular component organization or biogenesis DNA conformation change DNA topological change regulation of DNA recombination regulation of biological process DNA recombination biological regulation mitotic recombination regulation of macromolecule metabolic process regulation of mitotic recombination regulation of primary metabolic process regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA metabolic process DNA-templated DNA replication DNA strand elongation DNA strand elongation involved in DNA replication cellular biosynthetic process RNA metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process rRNA transcription organic substance biosynthetic process rRNA metabolic process cellular metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process biosynthetic process ncRNA metabolic process organic cyclic compound biosynthetic process transcription elongation by RNA polymerase II transcription by RNA polymerase II DNA-templated transcription elongation regulation of cellular process regulation of RNA metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II regulation of biosynthetic process regulation of cellular metabolic process regulation of cellular biosynthetic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of biological process nucleolar chromatin organization negative regulation of cellular metabolic process protein-DNA complex organization chromatin organization negative regulation of cellular process chromatin remodeling rDNA heterochromatin formation negative regulation of macromolecule metabolic process heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of gene expression nucleus organization negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process nucleolus organization facultative heterochromatin formation negative regulation of gene expression, epigenetic	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle replication fork protection complex protein-containing complex nuclear protein-containing complex nuclear replication fork nuclear chromosome chromosome replication fork nucleoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR048045	DNA topoisomerase I, DNA-binding domain	Domain
A	IPR011010	DNA breaking-rejoining enzyme, catalytic core	Homologous Superfamily
A	IPR001631	DNA topoisomerase I	Family
A	IPR013499	DNA topoisomerase I, eukaryotic-type	Domain
A	IPR036202	DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily	Homologous Superfamily
A	IPR008336	DNA topoisomerase I, DNA binding, eukaryotic-type	Domain
A	IPR014711	DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type	Homologous Superfamily
A	IPR013030	DNA topoisomerase I, DNA binding, N-terminal domain 2	Homologous Superfamily
A	IPR018521	DNA topoisomerase I, active site	Active Site
A	IPR013500	DNA topoisomerase I, catalytic core, eukaryotic-type	Domain
A	IPR025834	Topoisomerase I C-terminal domain	Domain
A	IPR013034	DNA topoisomerase I, DNA binding, N-terminal domain 1	Homologous Superfamily
A	IPR014727	DNA topoisomerase I, catalytic core, alpha/beta subdomain	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.