1OEL

CONFORMATIONAL VARIABILITY IN THE REFINED STRUCTURE OF THE CHAPERONIN GROEL AT 2.8 ANGSTROM RESOLUTION

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1oela1	All alpha proteins	GroEL equatorial domain-like	GroEL equatorial domain-like	GroEL chaperone, ATPase domain	GroEL, E domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A	d1oela2	Alpha and beta proteins (a/b)	The 'swivelling' beta/beta/alpha domain	GroEL apical domain-like	GroEL-like chaperone, apical domain	GroEL, A domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A	d1oela3	Alpha and beta proteins (a+b)	GroEL-intermediate domain like	GroEL-intermediate domain like	GroEL-like chaperone, intermediate domain	GroEL, I domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1oelb1	All alpha proteins	GroEL equatorial domain-like	GroEL equatorial domain-like	GroEL chaperone, ATPase domain	GroEL, E domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1oelb2	Alpha and beta proteins (a/b)	The 'swivelling' beta/beta/alpha domain	GroEL apical domain-like	GroEL-like chaperone, apical domain	GroEL, A domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1oelb3	Alpha and beta proteins (a+b)	GroEL-intermediate domain like	GroEL-intermediate domain like	GroEL-like chaperone, intermediate domain	GroEL, I domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d1oelc5	All alpha proteins	GroEL equatorial domain-like	GroEL equatorial domain-like	GroEL chaperone, ATPase domain	GroEL, E domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d1oelc3	Alpha and beta proteins (a/b)	The 'swivelling' beta/beta/alpha domain	GroEL apical domain-like	GroEL-like chaperone, apical domain	GroEL, A domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d1oelc4	Alpha and beta proteins (a+b)	GroEL-intermediate domain like	GroEL-intermediate domain like	GroEL-like chaperone, intermediate domain	GroEL, I domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D	d1oeld1	All alpha proteins	GroEL equatorial domain-like	GroEL equatorial domain-like	GroEL chaperone, ATPase domain	GroEL, E domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D	d1oeld2	Alpha and beta proteins (a/b)	The 'swivelling' beta/beta/alpha domain	GroEL apical domain-like	GroEL-like chaperone, apical domain	GroEL, A domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D	d1oeld3	Alpha and beta proteins (a+b)	GroEL-intermediate domain like	GroEL-intermediate domain like	GroEL-like chaperone, intermediate domain	GroEL, I domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
E	d1oele1	All alpha proteins	GroEL equatorial domain-like	GroEL equatorial domain-like	GroEL chaperone, ATPase domain	GroEL, E domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
E	d1oele2	Alpha and beta proteins (a/b)	The 'swivelling' beta/beta/alpha domain	GroEL apical domain-like	GroEL-like chaperone, apical domain	GroEL, A domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
E	d1oele3	Alpha and beta proteins (a+b)	GroEL-intermediate domain like	GroEL-intermediate domain like	GroEL-like chaperone, intermediate domain	GroEL, I domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
F	d1oelf1	All alpha proteins	GroEL equatorial domain-like	GroEL equatorial domain-like	GroEL chaperone, ATPase domain	GroEL, E domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
F	d1oelf2	Alpha and beta proteins (a/b)	The 'swivelling' beta/beta/alpha domain	GroEL apical domain-like	GroEL-like chaperone, apical domain	GroEL, A domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
F	d1oelf3	Alpha and beta proteins (a+b)	GroEL-intermediate domain like	GroEL-intermediate domain like	GroEL-like chaperone, intermediate domain	GroEL, I domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
G	d1oelg1	All alpha proteins	GroEL equatorial domain-like	GroEL equatorial domain-like	GroEL chaperone, ATPase domain	GroEL, E domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
G	d1oelg2	Alpha and beta proteins (a/b)	The 'swivelling' beta/beta/alpha domain	GroEL apical domain-like	GroEL-like chaperone, apical domain	GroEL, A domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
G	d1oelg3	Alpha and beta proteins (a+b)	GroEL-intermediate domain like	GroEL-intermediate domain like	GroEL-like chaperone, intermediate domain	GroEL, I domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	GroEL-intermediate domain like	8032390	3001087	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	GroEL apical domain-like	8043929	3000963	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	GroEL equatorial domain-like	8032389	3001651	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	GroEL-intermediate domain like	8032390	3001087	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	GroEL equatorial domain-like	8032389	3001651	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	GroEL-intermediate domain like	8032390	3001087	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	GroEL equatorial domain-like	8032389	3001651	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	GroEL equatorial domain-like	8032389	3001651	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	GroEL apical domain-like	8043929	3000963	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	GroEL-intermediate domain like	8032390	3001087	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	GroEL-intermediate domain like	8032390	3001087	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	GroEL-intermediate domain like	8032390	3001087	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	GroEL equatorial domain-like	8032389	3001651	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	GroEL equatorial domain-like	8032389	3001651	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	GroEL apical domain-like	8043929	3000963	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	GroEL-intermediate domain like	8032390	3001087	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	GroEL-intermediate domain like	8032390	3001087	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	GroEL apical domain-like	8043929	3000963	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	GroEL equatorial domain-like	8032389	3001651	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	GroEL equatorial domain-like	8032389	3001651	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	GroEL equatorial domain-like	8032389	3001651	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	GroEL-intermediate domain like	8032390	3001087	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	GroEL equatorial domain-like	8032389	3001651	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	GroEL apical domain-like	8043929	3000963	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	GroEL-intermediate domain like	8032390	3001087	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	GroEL equatorial domain-like	8032389	3001651	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	GroEL apical domain-like	8043929	3000963	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	GroEL equatorial domain-like	8032389	3001651	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	GroEL-intermediate domain like	8032390	3001087	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	GroEL-intermediate domain like	8032390	3001087	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	GroEL-intermediate domain like	8032390	3001087	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	GroEL-intermediate domain like	8032390	3001087	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	GroEL equatorial domain-like	8032389	3001651	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	GroEL apical domain-like	8043929	3000963	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	GroEL equatorial domain-like	8032389	3001651	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Cpn60_TCP1_1st	e1oelA1	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: Cpn60_TCP1_1st	ECOD (1.6)
A	Cpn60_TCP1_2nd_2	e1oelA3	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: Cpn60_TCP1_2nd_2	ECOD (1.6)
A	Cpn60_TCP1_3rd	e1oelA2	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: Cpn60_TCP1_3rd	ECOD (1.6)
B	Cpn60_TCP1_1st	e1oelB1	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: Cpn60_TCP1_1st	ECOD (1.6)
B	Cpn60_TCP1_2nd_2	e1oelB3	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: Cpn60_TCP1_2nd_2	ECOD (1.6)
B	Cpn60_TCP1_3rd	e1oelB2	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: Cpn60_TCP1_3rd	ECOD (1.6)
C	Cpn60_TCP1_1st	e1oelC1	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: Cpn60_TCP1_1st	ECOD (1.6)
C	Cpn60_TCP1_2nd_2	e1oelC3	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: Cpn60_TCP1_2nd_2	ECOD (1.6)
C	Cpn60_TCP1_3rd	e1oelC2	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: Cpn60_TCP1_3rd	ECOD (1.6)
D	Cpn60_TCP1_1st	e1oelD1	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: Cpn60_TCP1_1st	ECOD (1.6)
D	Cpn60_TCP1_2nd_2	e1oelD3	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: Cpn60_TCP1_2nd_2	ECOD (1.6)
D	Cpn60_TCP1_3rd	e1oelD2	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: Cpn60_TCP1_3rd	ECOD (1.6)
E	Cpn60_TCP1_1st	e1oelE1	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: Cpn60_TCP1_1st	ECOD (1.6)
E	Cpn60_TCP1_2nd_2	e1oelE3	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: Cpn60_TCP1_2nd_2	ECOD (1.6)
E	Cpn60_TCP1_3rd	e1oelE2	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: Cpn60_TCP1_3rd	ECOD (1.6)
F	Cpn60_TCP1_1st	e1oelF1	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: Cpn60_TCP1_1st	ECOD (1.6)
F	Cpn60_TCP1_2nd_2	e1oelF3	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: Cpn60_TCP1_2nd_2	ECOD (1.6)
F	Cpn60_TCP1_3rd	e1oelF2	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: Cpn60_TCP1_3rd	ECOD (1.6)
G	Cpn60_TCP1_1st	e1oelG1	A: alpha bundles	X: GroEL equatorial domain-like (From Topology)	H: GroEL equatorial domain-like (From Topology)	T: GroEL equatorial domain-like	F: Cpn60_TCP1_1st	ECOD (1.6)
G	Cpn60_TCP1_2nd_2	e1oelG3	A: a/b three-layered sandwiches	X: The swivelling beta/beta/alpha domains	H: The swivelling beta/beta/alpha domain (From Topology)	T: The swivelling beta/beta/alpha domain	F: Cpn60_TCP1_2nd_2	ECOD (1.6)
G	Cpn60_TCP1_3rd	e1oelG2	A: mixed a+b and a/b	X: Zincin-like	H: GroEL-intermediate domain like (From Topology)	T: GroEL-intermediate domain like	F: Cpn60_TCP1_3rd	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.560.10	Mainly Alpha	Orthogonal Bundle	GROEL	domain 1	CATH (4.3.0)
A	3.30.260.10	Alpha Beta	2-Layer Sandwich	GROEL	domain 2	CATH (4.3.0)
A	3.50.7.10	Alpha Beta	3-Layer(bba) Sandwich	GroEL	GroEL	CATH (4.3.0)
B	1.10.560.10	Mainly Alpha	Orthogonal Bundle	GROEL	domain 1	CATH (4.3.0)
B	3.30.260.10	Alpha Beta	2-Layer Sandwich	GROEL	domain 2	CATH (4.3.0)
B	3.50.7.10	Alpha Beta	3-Layer(bba) Sandwich	GroEL	GroEL	CATH (4.3.0)
C	1.10.560.10	Mainly Alpha	Orthogonal Bundle	GROEL	domain 1	CATH (4.3.0)
C	3.30.260.10	Alpha Beta	2-Layer Sandwich	GROEL	domain 2	CATH (4.3.0)
C	3.50.7.10	Alpha Beta	3-Layer(bba) Sandwich	GroEL	GroEL	CATH (4.3.0)
D	1.10.560.10	Mainly Alpha	Orthogonal Bundle	GROEL	domain 1	CATH (4.3.0)
D	3.30.260.10	Alpha Beta	2-Layer Sandwich	GROEL	domain 2	CATH (4.3.0)
D	3.50.7.10	Alpha Beta	3-Layer(bba) Sandwich	GroEL	GroEL	CATH (4.3.0)
E	1.10.560.10	Mainly Alpha	Orthogonal Bundle	GROEL	domain 1	CATH (4.3.0)
E	3.30.260.10	Alpha Beta	2-Layer Sandwich	GROEL	domain 2	CATH (4.3.0)
E	3.50.7.10	Alpha Beta	3-Layer(bba) Sandwich	GroEL	GroEL	CATH (4.3.0)
F	1.10.560.10	Mainly Alpha	Orthogonal Bundle	GROEL	domain 1	CATH (4.3.0)
F	3.30.260.10	Alpha Beta	2-Layer Sandwich	GROEL	domain 2	CATH (4.3.0)
F	3.50.7.10	Alpha Beta	3-Layer(bba) Sandwich	GroEL	GroEL	CATH (4.3.0)
G	1.10.560.10	Mainly Alpha	Orthogonal Bundle	GROEL	domain 1	CATH (4.3.0)
G	3.30.260.10	Alpha Beta	2-Layer Sandwich	GROEL	domain 2	CATH (4.3.0)
G	3.50.7.10	Alpha Beta	3-Layer(bba) Sandwich	GroEL	GroEL	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G	PF00118	TCP-1/cpn60 chaperonin family (Cpn60_TCP1)	TCP-1/cpn60 chaperonin family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G	GROEL (HSP60 CLASS)	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding unfolded protein binding protein binding isomerase activity catalytic activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides ATP-dependent activity ATP-dependent protein folding chaperone protein folding chaperone identical protein binding	protein refolding organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein refolding organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process chaperone cofactor-dependent protein refolding chaperone-mediated protein folding 'de novo' protein folding 'de novo' post-translational protein folding virion assembly viral process viral life cycle response to stimulus response to radiation response to abiotic stimulus response to stress response to heat response to temperature stimulus	membrane cellular anatomical entity protein-containing complex chaperonin ATPase complex intracellular anatomical structure protein folding chaperone complex GroEL-GroES complex cytoplasm cytosol intracellular protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G	IPR027413	GroEL-like equatorial domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G	IPR027410	TCP-1-like chaperonin intermediate domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G	IPR001844	Chaperonin Cpn60/GroEL	Family
A, B, C, D, E A, B, C, D, E, F, G	IPR018370	Chaperonin Cpn60, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G	IPR027409	GroEL-like apical domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G	IPR002423	Chaperonin Cpn60/GroEL/TCP-1 family	Family