1OED

STRUCTURE OF ACETYLCHOLINE RECEPTOR PORE FROM ELECTRON IMAGES

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1oeda_	Membrane and cell surface proteins and peptides	Neurotransmitter-gated ion-channel transmembrane pore	Neurotransmitter-gated ion-channel transmembrane pore	Neurotransmitter-gated ion-channel transmembrane pore	Acetylcholine receptor protein, alpha chain	(Torpedo marmorata ) [TaxId: 7788 ],	SCOPe (2.08)
D	d1oedd_	Membrane and cell surface proteins and peptides	Neurotransmitter-gated ion-channel transmembrane pore	Neurotransmitter-gated ion-channel transmembrane pore	Neurotransmitter-gated ion-channel transmembrane pore	Acetylcholine receptor protein, alpha chain	(Torpedo marmorata ) [TaxId: 7788 ],	SCOPe (2.08)
B	d1oedb_	Membrane and cell surface proteins and peptides	Neurotransmitter-gated ion-channel transmembrane pore	Neurotransmitter-gated ion-channel transmembrane pore	Neurotransmitter-gated ion-channel transmembrane pore	Acetylcholine receptor protein, beta chain	(Torpedo marmorata ) [TaxId: 7788 ],	SCOPe (2.08)
E	d1oede_	Membrane and cell surface proteins and peptides	Neurotransmitter-gated ion-channel transmembrane pore	Neurotransmitter-gated ion-channel transmembrane pore	Neurotransmitter-gated ion-channel transmembrane pore	Acetylcholine receptor protein, gamma chain	(Torpedo marmorata ) [TaxId: 7788 ],	SCOPe (2.08)
C	d1oedc_	Membrane and cell surface proteins and peptides	Neurotransmitter-gated ion-channel transmembrane pore	Neurotransmitter-gated ion-channel transmembrane pore	Neurotransmitter-gated ion-channel transmembrane pore	Acetylcholine receptor protein, delta chain	(Torpedo marmorata ) [TaxId: 7788 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Neurotransmitter-gated ion-channel transmembrane pore	8021633	4003801	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Neurotransmitter-gated ion-channel transmembrane pore	8034013	3001518	SCOP2 (2022-06-29)
B	SCOP2 Family	Neurotransmitter-gated ion-channel transmembrane pore	8021634	4003801	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Neurotransmitter-gated ion-channel transmembrane pore	8034014	3001518	SCOP2 (2022-06-29)
E	SCOP2 Family	Neurotransmitter-gated ion-channel transmembrane pore	8021640	4003801	SCOP2 (2022-06-29)
E	SCOP2 Superfamily	Neurotransmitter-gated ion-channel transmembrane pore	8034020	3001518	SCOP2 (2022-06-29)
C	SCOP2 Family	Neurotransmitter-gated ion-channel transmembrane pore	8021636	4003801	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	Neurotransmitter-gated ion-channel transmembrane pore	8034016	3001518	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Neur_chan_memb	e1oedA1	A: alpha bundles	X: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	H: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	T: Neurotransmitter-gated ion-channel transmembrane pore	F: Neur_chan_memb	ECOD (1.6)
D	Neur_chan_memb	e1oedD1	A: alpha bundles	X: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	H: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	T: Neurotransmitter-gated ion-channel transmembrane pore	F: Neur_chan_memb	ECOD (1.6)
B	Neur_chan_memb	e1oedB1	A: alpha bundles	X: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	H: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	T: Neurotransmitter-gated ion-channel transmembrane pore	F: Neur_chan_memb	ECOD (1.6)
E	Neur_chan_memb	e1oedE1	A: alpha bundles	X: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	H: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	T: Neurotransmitter-gated ion-channel transmembrane pore	F: Neur_chan_memb	ECOD (1.6)
C	Neur_chan_memb	e1oedC1	A: alpha bundles	X: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	H: Neurotransmitter-gated ion-channel transmembrane pore (From Topology)	T: Neurotransmitter-gated ion-channel transmembrane pore	F: Neur_chan_memb	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.58.390	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
D	1.20.58.390	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
B	1.20.58.390	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
E	1.20.58.390	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
C	1.20.58.390	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D	PF02932	Neurotransmitter-gated ion-channel transmembrane region (Neur_chan_memb)	Neurotransmitter-gated ion-channel transmembrane region	-	Family
A, D	PF02931	Neurotransmitter-gated ion-channel ligand binding domain (Neur_chan_LBD)	Neurotransmitter-gated ion-channel ligand binding domain	-	Family
B	PF02932	Neurotransmitter-gated ion-channel transmembrane region (Neur_chan_memb)	Neurotransmitter-gated ion-channel transmembrane region	-	Family
B	PF02931	Neurotransmitter-gated ion-channel ligand binding domain (Neur_chan_LBD)	Neurotransmitter-gated ion-channel ligand binding domain	-	Family
E	PF02932	Neurotransmitter-gated ion-channel transmembrane region (Neur_chan_memb)	Neurotransmitter-gated ion-channel transmembrane region	-	Family
E	PF02931	Neurotransmitter-gated ion-channel ligand binding domain (Neur_chan_LBD)	Neurotransmitter-gated ion-channel ligand binding domain	-	Family
C	PF02932	Neurotransmitter-gated ion-channel transmembrane region (Neur_chan_memb)	Neurotransmitter-gated ion-channel transmembrane region	-	Family
C	PF02931	Neurotransmitter-gated ion-channel ligand binding domain (Neur_chan_LBD)	Neurotransmitter-gated ion-channel ligand binding domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D	Acetylcholine receptor subunit alpha	transmitter-gated monoatomic ion channel activity monoatomic cation transmembrane transporter activity molecular transducer activity monoatomic ion channel activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential neurotransmitter receptor activity ligand-gated channel activity postsynaptic neurotransmitter receptor activity passive transmembrane transporter activity acetylcholine-gated monoatomic cation-selective channel activity transporter activity ligand-gated monoatomic cation channel activity gated channel activity signaling receptor activity transmitter-gated monoatomic ion channel activity monoatomic cation transmembrane transporter activity molecular transducer activity monoatomic ion channel activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential neurotransmitter receptor activity ligand-gated channel activity postsynaptic neurotransmitter receptor activity passive transmembrane transporter activity acetylcholine-gated monoatomic cation-selective channel activity transporter activity ligand-gated monoatomic cation channel activity gated channel activity signaling receptor activity excitatory extracellular ligand-gated monoatomic ion channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity monoatomic cation channel activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential channel activity monoatomic ion transmembrane transporter activity transmitter-gated channel activity transmembrane transporter activity transmembrane signaling receptor activity	-	cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane
B	Acetylcholine receptor beta subunit	transmitter-gated monoatomic ion channel activity monoatomic cation transmembrane transporter activity molecular transducer activity monoatomic ion channel activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential neurotransmitter receptor activity ligand-gated channel activity postsynaptic neurotransmitter receptor activity passive transmembrane transporter activity acetylcholine-gated monoatomic cation-selective channel activity transporter activity ligand-gated monoatomic cation channel activity gated channel activity signaling receptor activity transmitter-gated monoatomic ion channel activity monoatomic cation transmembrane transporter activity molecular transducer activity monoatomic ion channel activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential neurotransmitter receptor activity ligand-gated channel activity postsynaptic neurotransmitter receptor activity passive transmembrane transporter activity acetylcholine-gated monoatomic cation-selective channel activity transporter activity ligand-gated monoatomic cation channel activity gated channel activity signaling receptor activity excitatory extracellular ligand-gated monoatomic ion channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity monoatomic cation channel activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential channel activity monoatomic ion transmembrane transporter activity transmitter-gated channel activity transmembrane transporter activity transmembrane signaling receptor activity	-	cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane
E	Acetylcholine receptor gamma subunit	transmitter-gated monoatomic ion channel activity monoatomic cation transmembrane transporter activity molecular transducer activity monoatomic ion channel activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential neurotransmitter receptor activity ligand-gated channel activity postsynaptic neurotransmitter receptor activity passive transmembrane transporter activity acetylcholine-gated monoatomic cation-selective channel activity transporter activity ligand-gated monoatomic cation channel activity gated channel activity signaling receptor activity transmitter-gated monoatomic ion channel activity monoatomic cation transmembrane transporter activity molecular transducer activity monoatomic ion channel activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential neurotransmitter receptor activity ligand-gated channel activity postsynaptic neurotransmitter receptor activity passive transmembrane transporter activity acetylcholine-gated monoatomic cation-selective channel activity transporter activity ligand-gated monoatomic cation channel activity gated channel activity signaling receptor activity excitatory extracellular ligand-gated monoatomic ion channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity monoatomic cation channel activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential channel activity monoatomic ion transmembrane transporter activity transmitter-gated channel activity transmembrane transporter activity transmembrane signaling receptor activity	-	cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane
C	Acetylcholine receptor delta subunit	transmitter-gated monoatomic ion channel activity monoatomic cation transmembrane transporter activity molecular transducer activity monoatomic ion channel activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential neurotransmitter receptor activity ligand-gated channel activity postsynaptic neurotransmitter receptor activity passive transmembrane transporter activity acetylcholine-gated monoatomic cation-selective channel activity transporter activity ligand-gated monoatomic cation channel activity gated channel activity signaling receptor activity transmitter-gated monoatomic ion channel activity monoatomic cation transmembrane transporter activity molecular transducer activity monoatomic ion channel activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential neurotransmitter receptor activity ligand-gated channel activity postsynaptic neurotransmitter receptor activity passive transmembrane transporter activity acetylcholine-gated monoatomic cation-selective channel activity transporter activity ligand-gated monoatomic cation channel activity gated channel activity signaling receptor activity excitatory extracellular ligand-gated monoatomic ion channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity monoatomic cation channel activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential channel activity monoatomic ion transmembrane transporter activity transmitter-gated channel activity transmembrane transporter activity transmembrane signaling receptor activity	-	cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D	IPR002394	Nicotinic acetylcholine receptor	Family
A, D	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain	Domain
A, D	IPR018000	Neurotransmitter-gated ion-channel, conserved site	Conserved Site
A, D	IPR038050	Neuronal acetylcholine receptor	Homologous Superfamily
A, D	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain	Domain
A, D	IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily	Homologous Superfamily
A, D	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Homologous Superfamily
A, D	IPR006201	Neurotransmitter-gated ion-channel	Family
B	IPR002394	Nicotinic acetylcholine receptor	Family
B	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain	Domain
B	IPR018000	Neurotransmitter-gated ion-channel, conserved site	Conserved Site
B	IPR038050	Neuronal acetylcholine receptor	Homologous Superfamily
B	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain	Domain
B	IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily	Homologous Superfamily
B	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Homologous Superfamily
B	IPR006201	Neurotransmitter-gated ion-channel	Family
E	IPR002394	Nicotinic acetylcholine receptor	Family
E	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain	Domain
E	IPR018000	Neurotransmitter-gated ion-channel, conserved site	Conserved Site
E	IPR038050	Neuronal acetylcholine receptor	Homologous Superfamily
E	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain	Domain
E	IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily	Homologous Superfamily
E	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Homologous Superfamily
E	IPR006201	Neurotransmitter-gated ion-channel	Family
C	IPR002394	Nicotinic acetylcholine receptor	Family
C	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain	Domain
C	IPR018000	Neurotransmitter-gated ion-channel, conserved site	Conserved Site
C	IPR038050	Neuronal acetylcholine receptor	Homologous Superfamily
C	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain	Domain
C	IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily	Homologous Superfamily
C	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Homologous Superfamily
C	IPR006201	Neurotransmitter-gated ion-channel	Family