Annotations: 1NWQ

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C [auth A]	d1nwqa_	Coiled coil proteins	Parallel coiled-coil	Leucine zipper domain	Leucine zipper domain	C/ebp alpha	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
D [auth C]	d1nwqc_	Coiled coil proteins	Parallel coiled-coil	Leucine zipper domain	Leucine zipper domain	C/ebp alpha	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth A]	SCOP2 Family	Leucine zipper domain	8021279	4003836	SCOP2 (2022-06-29)
C [auth A]	SCOP2 Superfamily	Leucine zipper-like	8033659	3001609	SCOP2 (2022-06-29)
D [auth C]	SCOP2B Superfamily	Leucine zipper-like	8033659	3001609	SCOP2B (2022-06-29)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth A]	1.20.5.170	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
D [auth C]	1.20.5.170	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth A], D [auth C]	PF07716	Basic region leucine zipper (bZIP_2)	Basic region leucine zipper	-	Coiled-coil

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	5'-D(TPTPCPCPTPAPTPTPGPCPGPCPAPAPTPCPCPAPGPTP*T)-3'	-	-	-
B [auth D]	5'-D(APAPAPCPTPGPGPAPTPTPGPCPGPCPAPAPTPAPGPGP*A)-3'	-	-	-
C [auth A], D [auth C]	CCAAT/enhancer binding protein alpha	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding DNA-binding transcription factor binding STAT family protein binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding DNA-binding transcription factor binding STAT family protein binding histone deacetylase binding enzyme binding RNA polymerase I transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity protein-containing complex binding HMG box domain binding protein domain specific binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity identical protein binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding chromatin binding protein heterodimerization activity protein dimerization activity kinase binding protein homodimerization activity chromatin DNA binding	developmental process stem cell proliferation cell population proliferation cellular developmental process hemopoiesis cell differentiation anatomical structure development hematopoietic stem cell proliferation cell development cellular process cellular response to stimulus cellular response to inorganic substance cellular response to metal ion cellular response to lithium ion developmental process stem cell proliferation cell population proliferation cellular developmental process hemopoiesis cell differentiation anatomical structure development hematopoietic stem cell proliferation cell development cellular process cellular response to stimulus cellular response to inorganic substance cellular response to metal ion cellular response to lithium ion response to stimulus response to inorganic substance cellular response to chemical stimulus response to lithium ion response to metal ion response to chemical regulation of defense response regulation of biological process regulation of response to external stimulus defense response biological regulation positive regulation of biological process response to external stimulus regulation of inflammatory response positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stimulus regulation of response to stress response to stress positive regulation of defense response inflammatory response multicellular organismal process regulation of stem cell proliferation negative regulation of hematopoietic stem cell proliferation regulation of cellular process regulation of developmental process negative regulation of biological process regulation of cell differentiation regulation of cell development multicellular organism development negative regulation of stem cell proliferation negative regulation of cellular process regulation of immune system process regulation of multicellular organismal process negative regulation of cell differentiation negative regulation of hemopoiesis regulation of multicellular organismal development negative regulation of cell population proliferation negative regulation of developmental process negative regulation of cell development negative regulation of immune system process immune system process regulation of cell population proliferation regulation of hemopoiesis regulation of hematopoietic stem cell proliferation negative regulation of multicellular organismal process cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process ear development sensory organ development inner ear development animal organ development response to nutrient levels response to organic substance response to organonitrogen compound response to nutrient response to oxygen-containing compound response to nitrogen compound response to vitamin response to vitamin B2 response to organic cyclic compound negative regulation of cell cycle cell cycle regulation of cell cycle myeloid leukocyte differentiation granulocyte differentiation myeloid cell differentiation leukocyte differentiation behavior system process learning or memory nervous system process cognition memory RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic cyclic compound metabolic process nucleic acid biosynthetic process organic cyclic compound biosynthetic process response to ketone response to lipid response to endogenous stimulus response to glucocorticoid response to corticosteroid response to hormone response to steroid hormone response to dexamethasone regulation of primary metabolic process regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of DNA-templated transcription acute-phase response acute inflammatory response fat cell differentiation brown fat cell differentiation cellular response to xenobiotic stimulus response to xenobiotic stimulus negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process positive regulation of fat cell differentiation positive regulation of developmental process positive regulation of cell differentiation regulation of fat cell differentiation cell surface receptor signaling pathway signaling cell communication Notch signaling pathway signal transduction positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process epithelium development developmental maturation tissue development epithelial cell differentiation epithelial cell development anatomical structure maturation epithelial cell maturation cell maturation chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis cellular response to organic cyclic compound cellular response to organic substance organonitrogen compound metabolic process organonitrogen compound biosynthetic process amide biosynthetic process urea metabolic process nitrogen cycle metabolic process urea cycle small molecule metabolic process amide metabolic process white fat cell differentiation hepaticobiliary system development gland development liver development system development regulation of macrophage activation positive regulation of macrophage activation regulation of leukocyte activation cell activation regulation of cell activation myeloid leukocyte activation leukocyte activation macrophage activation positive regulation of cell activation positive regulation of leukocyte activation positive regulation of multicellular organismal process positive regulation of immune system process lipid homeostasis tube development respiratory tube development lung development respiratory system development organic hydroxy compound metabolic process sterol metabolic process steroid metabolic process cholesterol metabolic process alcohol metabolic process secondary alcohol metabolic process lipid metabolic process placenta development chordate embryonic development embryo development in utero embryonic development embryonic placenta development embryo development ending in birth or egg hatching embryonic organ development osteoblast development ossification osteoblast differentiation response to cytokine cellular response to tumor necrosis factor cellular response to cytokine stimulus response to tumor necrosis factor interleukin-6-mediated signaling pathway response to interleukin-6 cellular response to interleukin-6 cytokine-mediated signaling pathway macrophage differentiation mononuclear cell differentiation regulation of osteoblast differentiation positive regulation of osteoblast differentiation transcription by RNA polymerase I response to phenylpropanoid animal organ regeneration regeneration cellular component organization organelle organization cellular component organization or biogenesis mitochondrion organization	protein-containing complex transcription regulator complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen protein-containing complex transcription regulator complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix nucleolus intracellular non-membrane-bounded organelle non-membrane-bounded organelle RNA polymerase II transcription regulator complex nuclear protein-containing complex CHOP-C/EBP complex C/EBP complex Rb-E2F complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth A], D [auth C]	IPR031106	CCAAT/enhancer-binding protein C/EBP	Family
C [auth A], D [auth C]	IPR004827	Basic-leucine zipper domain	Domain
C [auth A], D [auth C]	IPR016468	CCAAT/enhancer-binding protein, chordates	Family
C [auth A], D [auth C]	IPR046347	Basic-leucine zipper domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.