Annotations: 1NLW

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
E [auth A]	d1nlwa_	All alpha proteins	HLH-like	HLH, helix-loop-helix DNA-binding domain	HLH, helix-loop-helix DNA-binding domain	Mad protein	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G [auth D]	d1nlwd_	All alpha proteins	HLH-like	HLH, helix-loop-helix DNA-binding domain	HLH, helix-loop-helix DNA-binding domain	Mad protein	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F [auth B]	d1nlwb_	All alpha proteins	HLH-like	HLH, helix-loop-helix DNA-binding domain	HLH, helix-loop-helix DNA-binding domain	Max protein	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H [auth E]	d1nlwe_	All alpha proteins	HLH-like	HLH, helix-loop-helix DNA-binding domain	HLH, helix-loop-helix DNA-binding domain	Max protein	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
E [auth A]	SCOP2 Family	HLH helix-loop-helix DNA-binding domain	8031493	4000913	SCOP2 (2022-06-29)
E [auth A]	SCOP2 Superfamily	HLH helix-loop-helix DNA-binding domain	8043871	3001962	SCOP2 (2022-06-29)
G [auth D]	SCOP2B Superfamily	HLH helix-loop-helix DNA-binding domain	8043871	3001962	SCOP2B (2022-06-29)
F [auth B]	SCOP2B Superfamily	HLH helix-loop-helix DNA-binding domain	8037240	3001962	SCOP2B (2022-06-29)
H [auth E]	SCOP2B Superfamily	HLH helix-loop-helix DNA-binding domain	8037240	3001962	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E [auth A]	HLH	e1nlwA1	A: alpha duplicates or obligate multimers	X: HLH-like	H: HLH, helix-loop-helix DNA-binding domain (From Topology)	T: HLH, helix-loop-helix DNA-binding domain	F: HLH	ECOD (1.6)
G [auth D]	HLH	e1nlwD1	A: alpha duplicates or obligate multimers	X: HLH-like	H: HLH, helix-loop-helix DNA-binding domain (From Topology)	T: HLH, helix-loop-helix DNA-binding domain	F: HLH	ECOD (1.6)
F [auth B]	HLH	e1nlwB1	A: alpha duplicates or obligate multimers	X: HLH-like	H: HLH, helix-loop-helix DNA-binding domain (From Topology)	T: HLH, helix-loop-helix DNA-binding domain	F: HLH	ECOD (1.6)
H [auth E]	HLH	e1nlwE1	A: alpha duplicates or obligate multimers	X: HLH-like	H: HLH, helix-loop-helix DNA-binding domain (From Topology)	T: HLH, helix-loop-helix DNA-binding domain	F: HLH	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
E [auth A]	4.10.280.10	Few Secondary Structures	Irregular	MYOD Basic-Helix-Loop-Helix Domain, subunit B	Helix-loop-helix DNA-binding domain	CATH (4.3.0)
G [auth D]	4.10.280.10	Few Secondary Structures	Irregular	MYOD Basic-Helix-Loop-Helix Domain, subunit B	Helix-loop-helix DNA-binding domain	CATH (4.3.0)
F [auth B]	4.10.280.10	Few Secondary Structures	Irregular	MYOD Basic-Helix-Loop-Helix Domain, subunit B	Helix-loop-helix DNA-binding domain	CATH (4.3.0)
H [auth E]	4.10.280.10	Few Secondary Structures	Irregular	MYOD Basic-Helix-Loop-Helix Domain, subunit B	Helix-loop-helix DNA-binding domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
E [auth A], G [auth D]	PF00010	Helix-loop-helix DNA-binding domain (HLH)	Helix-loop-helix DNA-binding domain	-	Domain
F [auth B], H [auth E]	PF00010	Helix-loop-helix DNA-binding domain (HLH)	Helix-loop-helix DNA-binding domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth F], B [auth G], C [auth H], D [auth J]	5'-D(GPAPGPTPAPGPCPAPCPGPTPGPCPTPAPCPTPC)-3'	-	-	-
E [auth A], G [auth D]	MAD PROTEIN	DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding protein dimerization activity	regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of biological process negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle Mad-Max complex RNA polymerase II transcription repressor complex protein-containing complex nucleus nuclear protein-containing complex transcription regulator complex membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle Mad-Max complex RNA polymerase II transcription repressor complex protein-containing complex nucleus nuclear protein-containing complex transcription regulator complex transcription repressor complex cytosol membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle
F [auth B], H [auth E]	MAX PROTEIN	DNA binding binding organic cyclic compound binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity transcription factor binding protein binding DNA-binding transcription factor binding E-box binding sequence-specific DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity transcription factor binding protein binding DNA-binding transcription factor binding E-box binding sequence-specific DNA binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein dimerization activity identical protein binding	regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process primary metabolic process regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process cellular process positive regulation of cellular biosynthetic process transcription by RNA polymerase II regulation of transcription by RNA polymerase II negative regulation of biological process negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process positive regulation of transcription by RNA polymerase II	RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle Mad-Max complex RNA polymerase II transcription repressor complex transcription repressor complex RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle Mad-Max complex RNA polymerase II transcription repressor complex transcription repressor complex Myc-Max complex somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection protein-DNA complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle histone methyltransferase complex catalytic complex MLL1/2 complex transferase complex MLL1 complex methyltransferase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
E [auth A], G [auth D]	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain	Domain
E [auth A], G [auth D]	IPR040157	Max dimerization protein 1, basic Helix-Loop-Helix-zipper domain	Domain
E [auth A], G [auth D]	IPR036638	Helix-loop-helix DNA-binding domain superfamily	Homologous Superfamily
F [auth B], H [auth E]	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain	Domain
F [auth B], H [auth E]	IPR036638	Helix-loop-helix DNA-binding domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
E [auth A], G [auth D]	Pharos: Q05195	allergic contact dermatitis ovarian cancer pancreatic intraductal papillary-mucinous neoplasm rheumatoid arthritis subependymal giant cell astrocytoma breast cancer esophageal adenocarcinoma gastric carcinoma interstitial cystitis lung cancer nasopharyngeal carcinoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia spina bifida tuberculosis allergic contact dermatitis ovarian cancer pancreatic intraductal papillary-mucinous neoplasm rheumatoid arthritis subependymal giant cell astrocytoma breast cancer esophageal adenocarcinoma gastric carcinoma interstitial cystitis lung cancer nasopharyngeal carcinoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia spina bifida tuberculosis atrial fibrillation cystic fibrosis exocrine pancreatic carcinoma glioblastoma invasive ductal breast carcinoma malignant ependymoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma psoriasis spondyloarthropathy atypical teratoid rhabdoid tumor diabetes mellitus gastric cancer hepatocellular carcinoma large cell medulloblastoma malignant pancreatic neoplasm
F [auth B], H [auth E]	Pharos: P61244	phaeochromocytoma Pheochromocytoma kidney Wilms tumor osteosarcoma Sjogren syndrome adrenal gland pheochromocytoma benign neoplasm of adrenal gland cancer dermatomyositis esophageal adenocarcinoma myopathy ovarian cancer subependymal giant cell astrocytoma adrenal medulla cancer colon carcinoma phaeochromocytoma Pheochromocytoma kidney Wilms tumor osteosarcoma Sjogren syndrome adrenal gland pheochromocytoma benign neoplasm of adrenal gland cancer dermatomyositis esophageal adenocarcinoma myopathy ovarian cancer subependymal giant cell astrocytoma adrenal medulla cancer colon carcinoma endometrial carcinoma extra-adrenal sympathetic paraganglioma neuroendocrine carcinoma psoriasis ulcerative colitis astrocytic tumor Crohn disease endometrium carcinoma in situ juvenile dermatomyositis

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.