1NJM

The crystal structure of the 50S Large ribosomal subunit from Deinococcus radiodurans complexed with a tRNA acceptor stem mimic (ASM) and the antibiotic sparsomycin

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C [auth K]	d1njmk_	Low resolution protein structures	Ribosome and ribosomal fragments	Ribosome and ribosomal fragments	Large subunit	Prokaryotic (50S subunit)	(Deinococcus radiodurans ) [TaxId: 1299 ],	SCOPe (2.08)
D [auth T]	d1njmt_	Low resolution protein structures	Ribosome and ribosomal fragments	Ribosome and ribosomal fragments	Large subunit	Prokaryotic (50S subunit)	(Deinococcus radiodurans ) [TaxId: 1299 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth K]	SCOP2B Superfamily	Ribosomal protein L16p/L10e	8038562	3000884	SCOP2B (2022-06-29)
D [auth T]	SCOP2B Superfamily	Ribosomal protein L25-like	8038580	3001161	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth K]	Ribosomal_L16	e1njmK1	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Ribosomal protein L10e	F: Ribosomal_L16	ECOD (1.6)
D [auth T]	Ribosomal_L25p	e1njmT1	A: beta barrels	X: Ribosomal protein L25-like	H: Ribosomal protein L25-like (From Topology)	T: Ribosomal protein L25-like	F: Ribosomal_L25p	ECOD (1.6)
D [auth T]	Ribosomal_TL5_C_1	e1njmT2	A: a+b complex topology	X: Ribosomal protein TL5/L25 C-terminal domain-like	H: Ribosomal protein TL5/L25 C-terminal domain-related (From Topology)	T: Ribosomal protein TL5/L25 C-terminal domain-related	F: Ribosomal_TL5_C_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth K]	PF00252	Ribosomal protein L16p/L10e (Ribosomal_L16)	Ribosomal protein L16p/L10e	-	Domain
D [auth T]	PF14693	Ribosomal protein TL5, C-terminal domain (Ribosomal_TL5_C)	Ribosomal protein TL5, C-terminal domain	This family contains the C-terminal domain of ribosomal protein TL5. The N-terminal domain, which binds to 5S rRNA, is contained in family Ribosomal_L25p, Pfam:PF01386. Full length (N- and C-terminal domain) homologues of TL5 are also known as CTC pr ...	This family contains the C-terminal domain of ribosomal protein TL5. The N-terminal domain, which binds to 5S rRNA, is contained in family Ribosomal_L25p, Pfam:PF01386. Full length (N- and C-terminal domain) homologues of TL5 are also known as CTC proteins. TL5 or CTC are not found in Eukarya or Archaea. In some Bacteria, including E. coli, this ribosomal subunit occurs as a single domain protein (named Ribosomal subunit L25), where the only domain is homologous to TL5 N-terminal domain (hence included in family Pfam:PF01386). The function of the C-terminal domain of TLC is at present unknown.	Domain
D [auth T]	PF01386	Ribosomal L25p family (Ribosomal_L25p)	Ribosomal L25p family	Ribosomal protein L25 is an RNA binding protein, that binds 5S rRNA. This family includes Ctc from B. subtilis Swiss:P14194, which is induced by stress.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth 0]	23S ribosomal RNA	-	-	-
B [auth 5]	tRNA acceptor stem mimic	-	-	-
C [auth K]	50S ribosomal protein L16	RNA binding binding organic cyclic compound binding tRNA binding nucleic acid binding structural molecule activity structural constituent of ribosome rRNA binding	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process	protein-containing complex intracellular anatomical structure cellular anatomical entity intracellular organelle ribosomal subunit cytosolic large ribosomal subunit cytosolic ribosome organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome cytoplasm cytosol large ribosomal subunit protein-containing complex intracellular anatomical structure cellular anatomical entity intracellular organelle ribosomal subunit cytosolic large ribosomal subunit cytosolic ribosome organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome cytoplasm cytosol large ribosomal subunit non-membrane-bounded organelle
D [auth T]	GENERAL STRESS PROTEIN CTC	RNA binding binding organic cyclic compound binding rRNA binding 5S rRNA binding nucleic acid binding tRNA binding structural molecule activity structural constituent of ribosome	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process	protein-containing complex intracellular anatomical structure cellular anatomical entity intracellular organelle ribosomal subunit cytosolic large ribosomal subunit cytosolic ribosome organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome cytoplasm cytosol large ribosomal subunit protein-containing complex intracellular anatomical structure cellular anatomical entity intracellular organelle ribosomal subunit cytosolic large ribosomal subunit cytosolic ribosome organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome cytoplasm cytosol large ribosomal subunit non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth K]	IPR036920	Large ribosomal subunit protein uL16 superfamily	Homologous Superfamily
C [auth K]	IPR020798	Large ribosomal subunit protein uL16, conserved site	Conserved Site
C [auth K]	IPR000114	Large ribosomal subunit protein uL16, bacterial-type	Family
C [auth K]	IPR016180	Large ribosomal subunit protein uL16 domain	Domain
C [auth K]	IPR047873	Large ribosomal subunit protein uL16	Family
D [auth T]	IPR011035	Large ribosomal subunit protein bL25/Gln-tRNA synthetase, anti-codon-binding domain superfamily	Homologous Superfamily
D [auth T]	IPR001021	Ribosomal protein bL25, long-form	Family
D [auth T]	IPR029751	Large ribosomal subunit protein bL25, L25 domain	Domain
D [auth T]	IPR037121	Large ribosomal subunit protein bL25, C-terminal	Homologous Superfamily
D [auth T]	IPR020057	Large ribosomal subunit protein bL25, beta domain	Domain
D [auth T]	IPR020056	Large ribosomal subunit protein bL25/Gln-tRNA synthetase, N-terminal	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.