Annotations: 1N4C

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1n4ca1	All alpha proteins	Long alpha-hairpin	Chaperone J-domain	Chaperone J-domain	Auxilin J-domain	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
A	d1n4ca2	Artifacts	Tags	Tags	Tags	N-terminal Tags	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Chaperone J-domain	8033756	3000721	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00226	e1n4cA1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: PF00226	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.287.110	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	DnaJ domain	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Auxilin	clathrin binding protein binding binding protein domain specific binding heat shock protein binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds protein tyrosine phosphatase activity phosphatase activity hydrolase activity catalytic activity clathrin heavy chain binding clathrin binding protein binding binding protein domain specific binding heat shock protein binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds protein tyrosine phosphatase activity phosphatase activity hydrolase activity catalytic activity clathrin heavy chain binding SH3 domain binding molecular adaptor activity	synaptic vesicle recycling localization cellular localization transport establishment of localization in cell synaptic vesicle cycle cellular process establishment of localization vesicle-mediated transport vesicle-mediated transport in synapse cellular component disassembly clathrin coat disassembly protein-containing complex organization protein-containing complex disassembly synaptic vesicle recycling localization cellular localization transport establishment of localization in cell synaptic vesicle cycle cellular process establishment of localization vesicle-mediated transport vesicle-mediated transport in synapse cellular component disassembly clathrin coat disassembly protein-containing complex organization protein-containing complex disassembly vesicle uncoating cellular component organization cellular component organization or biogenesis protein depolymerization import into cell clathrin-dependent endocytosis receptor-mediated endocytosis endocytosis intracellular transport synaptic vesicle uncoating presynaptic endocytosis synaptic vesicle endocytosis regulation of biological process regulation of cellular process regulation of cellular component organization biological regulation regulation of clathrin coat assembly regulation of cellular component biogenesis clathrin coat assembly cellular component biogenesis regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly dephosphorylation cellular metabolic process phosphate-containing compound metabolic process metabolic process phosphorus metabolic process	membrane-bounded organelle organelle cellular anatomical entity vesicle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle clathrin-coated vesicle coated vesicle cytoplasm presynapse synapse membrane-bounded organelle organelle cellular anatomical entity vesicle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle clathrin-coated vesicle coated vesicle cytoplasm presynapse synapse cell junction postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization asymmetric synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001623	DnaJ domain	Domain
A	IPR029023	Tensin-type phosphatase domain	Domain
A	IPR014020	Tensin phosphatase, C2 domain	Domain
A	IPR029021	Protein-tyrosine phosphatase-like	Homologous Superfamily
A	IPR036869	Chaperone J-domain superfamily	Homologous Superfamily
A	IPR000387	Tyrosine-specific protein phosphatases domain	Domain
A	IPR035892	C2 domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.