1MVF

MazE addiction antidote

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1mvfa_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	Camelid IG heavy chain variable domain, VHh	Arabian camel (Camelus dromedarius ) [TaxId: 9838 ],	SCOPe (2.08)
B	d1mvfb_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	Camelid IG heavy chain variable domain, VHh	Arabian camel (Camelus dromedarius ) [TaxId: 9838 ],	SCOPe (2.08)
C [auth D]	d1mvfd_	All beta proteins	Double-split beta-barrel	AbrB/MazE/MraZ-like	Kis/PemI addiction antidote	MazE	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D [auth E]	d1mvfe_	All beta proteins	Double-split beta-barrel	AbrB/MazE/MraZ-like	Kis/PemI addiction antidote	MazE	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth D]	SCOP2 Family	MazE-like	8020518	4000397	SCOP2 (2022-06-29)
C [auth D]	SCOP2 Superfamily	AbrB/MazE/MraZ-like	8032898	3000181	SCOP2 (2022-06-29)
D [auth E]	SCOP2B Superfamily	AbrB/MazE/MraZ-like	8032898	3000181	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	V-set_8	e1mvfA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
B	V-set_12	e1mvfB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
C [auth D]	MazE_antitoxin	e1mvfD1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: AbrB	F: MazE_antitoxin	ECOD (1.6)
D [auth E]	MazE_antitoxin	e1mvfE2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: AbrB	F: MazE_antitoxin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C [auth D]	2.10.260.10	Mainly Beta	Ribbon	Pemi-like Protein 1	Chain: D	CATH (4.3.0)
D [auth E]	2.10.260.10	Mainly Beta	Ribbon	Pemi-like Protein 1	Chain: D	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A, B	Immunoglobulin Heavy Chain Variable Region	VH	Camelus dromedarius (Arabian camel)	IGHV3S4501, IGHJ401	V-DOMAIN VH	IG	(VH)	IMGT (202415-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
A, B	Heavy Chain	IGHV1	-	pemi-like protein 1	SAbDab (2024-04-19)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth D], D [auth E]	PF04014	Antidote-toxin recognition MazE, bacterial antitoxin (MazE_antitoxin)	Antidote-toxin recognition MazE, bacterial antitoxin	AbrB-like is a family of small proteins that operate in conjunction with a cognate toxin molecule. The commonly attributed role of toxin-antitoxin systems is to maintain low-copy number plasmids from one generation to the next. Such gene-pairs are al ...	AbrB-like is a family of small proteins that operate in conjunction with a cognate toxin molecule. The commonly attributed role of toxin-antitoxin systems is to maintain low-copy number plasmids from one generation to the next. Such gene-pairs are also found on chromosomes and to be associated with a number of biological functions such as: reduction of protein synthesis, gene regulation and retardation of cell growth under nutritional stress [1]. This family includes proteins from a number of different pairings, eg MazE, AbrB, VapB [2], PhoU, PemI-like and SpoVT. MazE is the antidote to the toxin MazF of E. coli. MazE-MazF in E. coli is a regulated prokaryotic chromosomal addiction module. MazE antidote is degraded by the ClpPA protease of the bacterial proteasome. MazE-MazF is thought to play a role in programmed cell death when cells suffer nutrient deprivation [3], and MazE-MazF modules have also been implicated in the bacteriostatic effects of other addiction modules [3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	immunoglobulin heavy chain variable region	-	-	-
C [auth D], D [auth E]	PemI-like protein 1	DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding identical protein binding protein binding protein homodimerization activity protein dimerization activity protein-containing complex binding molecular sequestering activity toxin sequestering activity	regulation of growth regulation of biological process biological regulation growth regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process regulation of growth regulation of biological process biological regulation growth regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process cell aggregation biofilm formation biological process involved in intraspecies interaction between organisms single-species biofilm formation aggregation of unicellular organisms	protein-containing complex transcription regulator complex toxin-antitoxin complex transcription repressor complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth D], D [auth E]	IPR039052	Antitoxin PemI-like	Family
C [auth D], D [auth E]	IPR037914	SpoVT-AbrB domain superfamily	Homologous Superfamily
C [auth D], D [auth E]	IPR007159	SpoVT-AbrB domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.