1MSV

The S68A S-adenosylmethionine decarboxylase proenzyme processing mutant.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1msva_	Alpha and beta proteins (a+b)	S-adenosylmethionine decarboxylase	S-adenosylmethionine decarboxylase	S-adenosylmethionine decarboxylase	S-adenosylmethionine decarboxylase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1msvb_	Alpha and beta proteins (a+b)	S-adenosylmethionine decarboxylase	S-adenosylmethionine decarboxylase	S-adenosylmethionine decarboxylase	S-adenosylmethionine decarboxylase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	S-adenosylmethionine decarboxylase	8032867	3001051	SCOP2B (2022-06-29)
B	SCOP2 Family	S-adenosylmethionine decarboxylase	8020487	4002286	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	S-adenosylmethionine decarboxylase	8032867	3001051	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SAM_decarbox	e1msvA1	A: a+b two layers	X: TBP-like	H: S-adenosylmethionine decarboxylase-related	T: S-adenosylmethionine decarboxylase	F: SAM_decarbox	ECOD (1.6)
B	SAM_decarbox	e1msvB1	A: a+b two layers	X: TBP-like	H: S-adenosylmethionine decarboxylase-related	T: S-adenosylmethionine decarboxylase	F: SAM_decarbox	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.60.90.10	Alpha Beta	4-Layer Sandwich	S-adenosylmethionine decarboxylase	S-adenosylmethionine decarboxylase	CATH (4.3.0)
B	3.60.90.10	Alpha Beta	4-Layer Sandwich	S-adenosylmethionine decarboxylase	S-adenosylmethionine decarboxylase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01536	Adenosylmethionine decarboxylase (SAM_decarbox)	Adenosylmethionine decarboxylase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	S-adenosylmethionine decarboxylase proenzyme	cation binding polyamine binding binding ion binding amine binding putrescine binding small molecule binding adenosylmethionine decarboxylase activity carboxy-lyase activity lyase activity catalytic activity carbon-carbon lyase activity identical protein binding protein binding	organonitrogen compound metabolic process organonitrogen compound biosynthetic process polyamine metabolic process amine metabolic process biogenic amine biosynthetic process spermidine metabolic process organic substance metabolic process biosynthetic process amine biosynthetic process polyamine biosynthetic process organic substance biosynthetic process metabolic process spermidine biosynthetic process biogenic amine metabolic process organonitrogen compound metabolic process organonitrogen compound biosynthetic process polyamine metabolic process amine metabolic process biogenic amine biosynthetic process spermidine metabolic process organic substance metabolic process biosynthetic process amine biosynthetic process polyamine biosynthetic process organic substance biosynthetic process metabolic process spermidine biosynthetic process biogenic amine metabolic process spermine metabolic process spermine biosynthetic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR016067	S-adenosylmethionine decarboxylase, core	Homologous Superfamily
A, B	IPR001985	S-adenosylmethionine decarboxylase, eukaryotes	Family
A, B	IPR048283	S-adenosylmethionine decarboxylase-like	Family
A, B	IPR018166	S-adenosylmethionine decarboxylase, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P17707	glycogen storage disease II ovarian cancer invasive ductal breast carcinoma lung adenocarcinoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.