1MR9

Crystal structure of Streptogramin A Acetyltransferase with acetyl-CoA bound

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
AMR Gene: CARD Annotation
AMR Gene Family: CARD Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
E [auth Y]	d1mr9y_	All beta proteins	Single-stranded left-handed beta-helix	Trimeric LpxA-like enzymes	Galactoside acetyltransferase-like	Xenobiotic acetyltransferase	(Enterococcus faecium ) [TaxId: 1352 ],	SCOPe (2.08)
A	d1mr9a_	All beta proteins	Single-stranded left-handed beta-helix	Trimeric LpxA-like enzymes	Galactoside acetyltransferase-like	Xenobiotic acetyltransferase	(Enterococcus faecium ) [TaxId: 1352 ],	SCOPe (2.08)
B	d1mr9b_	All beta proteins	Single-stranded left-handed beta-helix	Trimeric LpxA-like enzymes	Galactoside acetyltransferase-like	Xenobiotic acetyltransferase	(Enterococcus faecium ) [TaxId: 1352 ],	SCOPe (2.08)
C	d1mr9c_	All beta proteins	Single-stranded left-handed beta-helix	Trimeric LpxA-like enzymes	Galactoside acetyltransferase-like	Xenobiotic acetyltransferase	(Enterococcus faecium ) [TaxId: 1352 ],	SCOPe (2.08)
D [auth X]	d1mr9x_	All beta proteins	Single-stranded left-handed beta-helix	Trimeric LpxA-like enzymes	Galactoside acetyltransferase-like	Xenobiotic acetyltransferase	(Enterococcus faecium ) [TaxId: 1352 ],	SCOPe (2.08)
F [auth Z]	d1mr9z_	All beta proteins	Single-stranded left-handed beta-helix	Trimeric LpxA-like enzymes	Galactoside acetyltransferase-like	Xenobiotic acetyltransferase	(Enterococcus faecium ) [TaxId: 1352 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
E [auth Y]	SCOP2B Superfamily	Trimeric LpxA-like enzymes	8036503	3001804	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Trimeric LpxA-like enzymes	8036503	3001804	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Trimeric LpxA-like enzymes	8036503	3001804	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Trimeric LpxA-like enzymes	8036503	3001804	SCOP2B (2022-06-29)
D [auth X]	SCOP2B Superfamily	Trimeric LpxA-like enzymes	8036503	3001804	SCOP2B (2022-06-29)
F [auth Z]	SCOP2B Superfamily	Trimeric LpxA-like enzymes	8036503	3001804	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E [auth Y]	PF00132	e1mr9Y1	A: beta duplicates or obligate multimers	X: Single-stranded left-handed beta-helix	H: Trimeric LpxA-like enzymes (From Topology)	T: Trimeric LpxA-like enzymes	F: PF00132	ECOD (1.6)
A	PF00132	e1mr9A1	A: beta duplicates or obligate multimers	X: Single-stranded left-handed beta-helix	H: Trimeric LpxA-like enzymes (From Topology)	T: Trimeric LpxA-like enzymes	F: PF00132	ECOD (1.6)
B	PF00132	e1mr9B1	A: beta duplicates or obligate multimers	X: Single-stranded left-handed beta-helix	H: Trimeric LpxA-like enzymes (From Topology)	T: Trimeric LpxA-like enzymes	F: PF00132	ECOD (1.6)
C	PF00132	e1mr9C1	A: beta duplicates or obligate multimers	X: Single-stranded left-handed beta-helix	H: Trimeric LpxA-like enzymes (From Topology)	T: Trimeric LpxA-like enzymes	F: PF00132	ECOD (1.6)
D [auth X]	PF00132	e1mr9X1	A: beta duplicates or obligate multimers	X: Single-stranded left-handed beta-helix	H: Trimeric LpxA-like enzymes (From Topology)	T: Trimeric LpxA-like enzymes	F: PF00132	ECOD (1.6)
F [auth Z]	PF00132	e1mr9Z1	A: beta duplicates or obligate multimers	X: Single-stranded left-handed beta-helix	H: Trimeric LpxA-like enzymes (From Topology)	T: Trimeric LpxA-like enzymes	F: PF00132	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
E [auth Y]	2.160.10.10	Mainly Beta	3 Solenoid	UDP N-Acetylglucosamine Acyltransferase	domain 1	CATH (4.3.0)
A	2.160.10.10	Mainly Beta	3 Solenoid	UDP N-Acetylglucosamine Acyltransferase	domain 1	CATH (4.3.0)
B	2.160.10.10	Mainly Beta	3 Solenoid	UDP N-Acetylglucosamine Acyltransferase	domain 1	CATH (4.3.0)
C	2.160.10.10	Mainly Beta	3 Solenoid	UDP N-Acetylglucosamine Acyltransferase	domain 1	CATH (4.3.0)
D [auth X]	2.160.10.10	Mainly Beta	3 Solenoid	UDP N-Acetylglucosamine Acyltransferase	domain 1	CATH (4.3.0)
F [auth Z]	2.160.10.10	Mainly Beta	3 Solenoid	UDP N-Acetylglucosamine Acyltransferase	domain 1	CATH (4.3.0)

AMR Gene: CARD Annotation CARD Database Homepage

Chains	Accession	Short Name	Description	Provenance Source (Version)
A, B, C, D [auth X], E [auth Y], A, B, C, D [auth X], E [auth Y], F [auth Z]	ARO:3002843	vatD	vatD is a transposon-mediated acetyltransferase found in Enterococcus faecium.	CARD (3.2.9)

AMR Gene Family: CARD Annotation CARD Database Homepage

Chains	Accession	Gene Family	Drug Class	Resistance Machanism	Provenance Source (Version)
A, B, C, D [auth X], E [auth Y], A, B, C, D [auth X], E [auth Y], F [auth Z]	ARO:3000453	streptogramin vat acetyltransferase	streptogramin antibiotic, streptogramin A antibiotic	antibiotic inactivation	CARD (3.2.9)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D [auth X], E [auth Y], A, B, C, D [auth X], E [auth Y], F [auth Z]	PF00132	Bacterial transferase hexapeptide (six repeats) (Hexapep)	Bacterial transferase hexapeptide (six repeats)	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D [auth X], E [auth Y], A, B, C, D [auth X], E [auth Y], F [auth Z]	Streptogramin A Acetyltransferase	acyltransferase activity transferase activity catalytic activity	response to stimulus response to chemical response to antibiotic	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D [auth X], E [auth Y], A, B, C, D [auth X], E [auth Y], F [auth Z]	IPR011004	Trimeric LpxA-like superfamily	Homologous Superfamily
A, B, C, D [auth X], E [auth Y], A, B, C, D [auth X], E [auth Y], F [auth Z]	IPR018357	Hexapeptide transferase, conserved site	Conserved Site
A, B, C, D [auth X], E [auth Y], A, B, C, D [auth X], E [auth Y], F [auth Z]	IPR001451	Hexapeptide repeat	Repeat

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.