Annotations: 1MO8

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1mo8a_	Alpha and beta proteins (a+b)	Metal cation-transporting ATPase, ATP-binding domain N	Metal cation-transporting ATPase, ATP-binding domain N	Metal cation-transporting ATPase, ATP-binding domain N	Sodium/potassium-transporting ATPase alpha chain	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Metal cation-transporting ATPase ATP-binding domain N	8032814	3000981	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF13246	e1mo8A1	A: a+b complex topology	X: Metal cation-transporting ATPase, ATP-binding domain (From Topology)	H: Metal cation-transporting ATPase, ATP-binding domain (From Topology)	T: Metal cation-transporting ATPase, ATP-binding domain	F: PF13246	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.1110.10	Alpha Beta	3-Layer(aba) Sandwich	Calcium-transporting ATPase, cytoplasmic domain N	Calcium-transporting ATPase, cytoplasmic domain N	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13246	Cation transport ATPase (P-type) (Cation_ATPase)	Cation transport ATPase (P-type)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Sodium/Potassium-Transporting ATPase alpha-1	cytoskeletal protein binding ankyrin binding protein binding binding monoatomic cation transmembrane transporter activity P-type transmembrane transporter activity P-type sodium transporter activity potassium ion transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity P-type sodium:potassium-exchanging transporter activity ATPase-coupled monoatomic cation transmembrane transporter activity sodium ion transmembrane transporter activity ATP-dependent activity cytoskeletal protein binding ankyrin binding protein binding binding monoatomic cation transmembrane transporter activity P-type transmembrane transporter activity P-type sodium transporter activity potassium ion transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity P-type sodium:potassium-exchanging transporter activity ATPase-coupled monoatomic cation transmembrane transporter activity sodium ion transmembrane transporter activity ATP-dependent activity P-type potassium transmembrane transporter activity P-type ion transporter activity active monoatomic ion transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity phosphatidylinositol 3-kinase binding protein-folding chaperone binding steroid hormone binding organic cyclic compound binding steroid binding lipid binding hormone binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ADP binding cation binding alkali metal ion binding sodium ion binding metal ion binding potassium ion binding protein domain specific binding protein heterodimerization activity protein dimerization activity kinase binding enzyme binding protein kinase binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides	response to stimulus response to chemical response to xenobiotic stimulus transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process response to stimulus response to chemical response to xenobiotic stimulus transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport multicellular organismal process system process circulatory system process regulation of blood pressure biological regulation regulation of biological quality blood circulation membrane repolarization regulation of membrane potential sodium ion export across plasma membrane export from cell sodium ion transmembrane transport export across plasma membrane metal ion transport sodium ion transport cellular response to stimulus response to organic substance response to lipid response to endogenous stimulus cellular response to organic cyclic compound cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to steroid hormone cellular response to lipid cellular response to organic substance cellular response to steroid hormone stimulus response to organic cyclic compound cellular response to hormone stimulus regulation of biological process regulation of system process positive regulation of biological process muscle contraction muscle system process regulation of muscle system process striated muscle contraction regulation of striated muscle contraction regulation of muscle contraction positive regulation of striated muscle contraction positive regulation of muscle contraction positive regulation of multicellular organismal process regulation of multicellular organismal process membrane hyperpolarization heart process regulation of heart contraction positive regulation of blood circulation positive regulation of heart contraction regulation of blood circulation heart contraction potassium ion homeostasis inorganic ion homeostasis homeostatic process cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis intracellular potassium ion homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis regulation of actin filament-based process regulation of cellular process cardiac muscle contraction actin filament-based process cardiac muscle cell contraction regulation of cardiac muscle contraction actin filament-based movement regulation of actin filament-based movement regulation of cardiac muscle cell contraction actin-mediated cell contraction sodium ion homeostasis intracellular sodium ion homeostasis relaxation of cardiac muscle relaxation of muscle establishment or maintenance of transmembrane electrochemical gradient regulation of the force of heart contraction negative regulation of biological process negative regulation of blood circulation negative regulation of heart contraction negative regulation of multicellular organismal process energy coupled proton transmembrane transport, against electrochemical gradient potassium ion transport response to mechanical stimulus response to external stimulus response to abiotic stimulus cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus import into cell import across plasma membrane potassium ion transmembrane transport inorganic cation import across plasma membrane inorganic ion import across plasma membrane potassium ion import across plasma membrane regulation of hormone biosynthetic process regulation of lipid metabolic process negative regulation of lipid biosynthetic process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of hormone biosynthetic process organic substance biosynthetic process hormone biosynthetic process negative regulation of steroid hormone biosynthetic process regulation of steroid hormone biosynthetic process negative regulation of steroid metabolic process regulation of hormone levels cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process glucocorticoid metabolic process glucocorticoid biosynthetic process organic cyclic compound metabolic process biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of metabolic process negative regulation of hormone metabolic process negative regulation of lipid metabolic process regulation of steroid biosynthetic process regulation of hormone metabolic process cellular biosynthetic process steroid metabolic process lipid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of glucocorticoid metabolic process regulation of glucocorticoid biosynthetic process steroid biosynthetic process steroid hormone biosynthetic process regulation of biosynthetic process negative regulation of glucocorticoid biosynthetic process negative regulation of glucocorticoid metabolic process regulation of steroid metabolic process hormone metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process negative regulation of steroid biosynthetic process regulation of lipid biosynthetic process lipid metabolic process response to glycoside response to oxygen-containing compound regulation of localization regulation of transport regulation of monoatomic ion transport regulation of sodium ion transport regulation of metal ion transport	cell periphery sarcolemma plasma membrane membrane T-tubule cellular anatomical entity membrane-bounded organelle cell projection organelle cilium 9+2 motile cilium sperm flagellum motile cilium plasma membrane bounded cell projection cell periphery sarcolemma plasma membrane membrane T-tubule cellular anatomical entity membrane-bounded organelle cell projection organelle cilium 9+2 motile cilium sperm flagellum motile cilium plasma membrane bounded cell projection basal part of cell basal plasma membrane plasma membrane region basolateral plasma membrane intracellular organelle intracellular anatomical structure Golgi apparatus cytoplasm intracellular membrane-bounded organelle endomembrane system axon neuron projection cell-cell junction intercalated disc anchoring junction cell junction cell-cell contact zone organelle membrane pigment granule intracellular vesicle melanosome cytoplasmic vesicle vesicle apical part of cell apical plasma membrane membrane microdomain membrane raft plasma membrane raft caveola protein-containing complex endosome postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization synapse asymmetric synapse ATPase dependent transmembrane transport complex plasma membrane protein complex membrane protein complex sodium:potassium-exchanging ATPase complex transporter complex cation-transporting ATPase complex transmembrane transporter complex lateral plasma membrane endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001757	P-type ATPase	Family
A	IPR018303	P-type ATPase, phosphorylation site	PTM
A	IPR023298	P-type ATPase, transmembrane domain superfamily	Homologous Superfamily
A	IPR036412	HAD-like superfamily	Homologous Superfamily
A	IPR023299	P-type ATPase, cytoplasmic domain N	Homologous Superfamily
A	IPR005775	P-type ATPase subfamily IIC, subunit alpha	Family
A	IPR004014	Cation-transporting P-type ATPase, N-terminal	Domain
A	IPR044492	P-type ATPase, haloacid dehalogenase domain	Domain
A	IPR006068	Cation-transporting P-type ATPase, C-terminal	Domain
A	IPR023214	HAD superfamily	Homologous Superfamily
A	IPR008250	P-type ATPase, A domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.