Annotations: 1MAH

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1maha_	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	Acetylcholinesterase-like	Acetylcholinesterase	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B [auth F]	d1mahf_	Small proteins	Snake toxin-like	Snake toxin-like	Snake venom toxins	Fasciculin	(Dendroaspis angusticeps ) [TaxId: 8618 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	alpha/beta-Hydrolases	8042208	3000102	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	COesterase	e1mahA1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: COesterase	ECOD (1.6)
B [auth F]	Toxin_TOLIP	e1mahF1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: Toxin_TOLIP	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
B [auth F]	2.10.60.10	Mainly Beta	Ribbon	CD59	CD59	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00135	Carboxylesterase family (COesterase)	Carboxylesterase family	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	ACETYLCHOLINESTERASE	hydrolase activity catalytic activity extracellular matrix binding binding protein binding laminin binding hydrolase activity, acting on ester bonds cholinesterase activity carboxylic ester hydrolase activity identical protein binding acetylcholinesterase activity cation binding acetylcholine binding ion binding hydrolase activity catalytic activity extracellular matrix binding binding protein binding laminin binding hydrolase activity, acting on ester bonds cholinesterase activity carboxylic ester hydrolase activity identical protein binding acetylcholinesterase activity cation binding acetylcholine binding ion binding small molecule binding choline binding collagen binding protein-containing complex binding protein homodimerization activity protein dimerization activity serine hydrolase activity	localization import into cell receptor internalization transport cellular process receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport developmental process multicellular organismal process sensory organ development eye development animal organ development localization import into cell receptor internalization transport cellular process receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport developmental process multicellular organismal process sensory organ development eye development animal organ development retina development in camera-type eye visual system development multicellular organism development camera-type eye development anatomical structure development sensory system development system development positive regulation of nervous system development axonogenesis regulation of cellular process cell projection organization regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell development positive regulation of developmental process cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation positive regulation of cell projection organization regulation of biological process regulation of cell projection organization positive regulation of cell development nervous system development generation of neurons positive regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cellular developmental process regulation of developmental process plasma membrane bounded cell projection morphogenesis positive regulation of biological process cell development cell morphogenesis cellular component organization regulation of nervous system development neurogenesis positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis regulation of multicellular organismal process cellular component organization or biogenesis positive regulation of axonogenesis regulation of anatomical structure morphogenesis positive regulation of cellular process regulation of multicellular organismal development plasma membrane bounded cell projection organization biological regulation axon development cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis neuron development regulation of plasma membrane bounded cell projection organization cell adhesion ammonium ion metabolic process organic substance metabolic process choline metabolic process metabolic process acetate ester metabolic process acetylcholine metabolic process cellular response to nitrogen compound cellular response to stimulus cellular response to acetylcholine response to organic substance response to stimulus signaling response to oxygen-containing compound cell-cell signaling response to nitrogen compound acetylcholine receptor signaling pathway postsynaptic signal transduction cellular response to oxygen-containing compound cell communication cellular response to chemical stimulus synaptic signaling response to chemical response to acetylcholine signal transduction cellular component biogenesis cell junction organization cellular component assembly cell junction assembly synapse organization synapse assembly regulation of signaling regulation of receptor recycling regulation of macromolecule metabolic process receptor recycling receptor metabolic process macromolecule metabolic process regulation of metabolic process osteoblast development ossification osteoblast differentiation catabolic process acetylcholine catabolic process organic substance catabolic process homeostatic process adaptive thermogenesis positive regulation of metabolic process multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis response to hormone response to endogenous stimulus response to organonitrogen compound response to peptide hormone response to insulin regulation of cell morphogenesis regulation of dendrite morphogenesis positive regulation of cell morphogenesis regulation of dendrite development dendrite development positive regulation of dendrite morphogenesis dendrite morphogenesis	cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure cell periphery postsynapse postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region cellular anatomical entity synaptic membrane membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system basement membrane extracellular matrix external encapsulating structure collagen-containing extracellular matrix presynapse presynaptic membrane synaptic cleft extracellular region somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection neuromuscular junction side of membrane Golgi apparatus cytoplasm membrane-enclosed lumen intracellular organelle lumen endoplasmic reticulum lumen organelle lumen endoplasmic reticulum perinuclear region of cytoplasm cell body neuronal cell body axon extracellular space cell surface
B [auth F]	FASCICULIN 2	toxin activity	-	extracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000997	Cholinesterase	Family
A	IPR002018	Carboxylesterase, type B	Domain
A	IPR019819	Carboxylesterase type B, conserved site	Conserved Site
A	IPR019826	Carboxylesterase type B, active site	Active Site
A	IPR029058	Alpha/Beta hydrolase fold	Homologous Superfamily
A	IPR014788	Acetylcholinesterase, tetramerisation domain	Domain
B [auth F]	IPR018354	Snake toxin, conserved site	Conserved Site
B [auth F]	IPR045860	Snake toxin-like superfamily	Homologous Superfamily

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	acetylcholinesterase M-CSA #922	This enzyme is found in, or attached to, cellular or basement membranes of presynaptic cholinergic neurons and postsynaptic cholinoceptive cells within the neuromuscular junction. Signal transmission at the neuromuscular junction involves the release of acylcholine, its interaction with the acycholine receptor and hydrolysis, all occuring in a period of a few milliseconds. Rapid hydrolysis of the newly released aceytlcholine is vital in order to prevent continuous firing of the nerve impulses [PMID:8161450].	Defined by 8 residues: GLY:A-121GLY:A-122SER:A-203ALA:A-204PHE:A-295GLU:A-334PHE:A-338HIS:A-447 \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 3.1.1.7 (PDB Primary Data) Search M-CSA Motif + EC 3.1.1.7

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.