1M4U

Crystal structure of Bone Morphogenetic Protein-7 (BMP-7) in complex with the secreted antagonist Noggin

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth L]	d1m4ul_	Small proteins	Cystine-knot cytokines	Cystine-knot cytokines	Transforming growth factor (TGF)-beta	Bone morphogenetic protein-7 (BMP-7)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth A]	d1m4ua1	Small proteins	Cystine-knot cytokines	Cystine-knot cytokines	Noggin	Noggin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth A]	d1m4ua2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth L]	SCOP2B Superfamily	Cystine-knot cytokines	8032606	3000846	SCOP2B (2022-06-29)
B [auth A]	SCOP2 Family	Noggin	8030908	4003414	SCOP2 (2022-06-29)
B [auth A]	SCOP2 Superfamily	Cystine-knot cytokines	8043287	3000846	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth L]	PF00019	e1m4uL1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: PF00019	ECOD (1.6)
B [auth A]	PF05806	e1m4uA1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: PF05806	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth L]	2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	CATH (4.3.0)
B [auth A]	2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	CATH (4.3.0)
B [auth A]	1.10.287.520	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth L]	PF00019	Transforming growth factor beta like domain (TGF_beta)	Transforming growth factor beta like domain	-	Domain
B [auth A]	PF05806	Noggin (Noggin)	Noggin	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth L]	Bone Morphogenetic Protein-7	protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity BMP receptor binding receptor serine/threonine kinase binding transmembrane receptor protein serine/threonine kinase binding cytokine activity heparin binding protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity BMP receptor binding receptor serine/threonine kinase binding transmembrane receptor protein serine/threonine kinase binding cytokine activity heparin binding glycosaminoglycan binding carbohydrate derivative binding sulfur compound binding	developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process regulation of cell differentiation neurogenesis neuron differentiation cell differentiation negative regulation of cellular process negative regulation of cell differentiation regulation of biological process negative regulation of developmental process biological regulation nervous system development generation of neurons cellular process negative regulation of neuron differentiation regulation of neuron differentiation cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of signaling cell surface receptor signaling pathway positive regulation of intracellular signal transduction positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway SMAD protein signal transduction regulation of response to stimulus regulation of cell communication regulation of SMAD protein signal transduction positive regulation of SMAD protein signal transduction positive regulation of signaling phosphorylation cellular metabolic process regulation of cellular metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process regulation of phosphorylation regulation of phosphorus metabolic process metabolic process phosphorus metabolic process regulation of metabolic process embryonic epithelial tube formation chordate embryonic development neural fold formation tube formation embryo development epithelial tube formation primary neural tube formation tube morphogenesis neural fold elevation formation embryo development ending in birth or egg hatching epithelial tube morphogenesis morphogenesis of an epithelial fold morphogenesis of embryonic epithelium epithelium development neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium tissue morphogenesis anatomical structure morphogenesis neural tube formation anatomical structure formation involved in morphogenesis head development brain development central nervous system development hindbrain development epithelial cell differentiation regulation of epithelial cell differentiation positive regulation of developmental process positive regulation of cell differentiation regulation of multicellular organismal process regulation of multicellular organismal development positive regulation of epithelial cell differentiation extraembryonic membrane development allantois development branching morphogenesis of an epithelial tube morphogenesis of a branching structure morphogenesis of a branching epithelium renal system development kidney vasculature development negative regulation of cell proliferation involved in kidney development renal system vasculature development regulation of glomerular mesangial cell proliferation negative regulation of glomerular mesangial cell proliferation nephron development blood vessel development negative regulation of cell population proliferation cell population proliferation cell proliferation involved in kidney development glomerular mesangium development regulation of cell proliferation involved in kidney development vasculature development circulatory system development glomerulus development regulation of cell population proliferation glomerular mesangial cell proliferation glomerulus vasculature development kidney development negative regulation of mesenchymal cell apoptotic process regulation of somatic stem cell population maintenance regulation of programmed cell death stem cell population maintenance negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis mesenchymal cell apoptotic process involved in nephron morphogenesis somatic stem cell population maintenance animal organ morphogenesis negative regulation of programmed cell death regulation of apoptotic process regulation of mesenchymal cell apoptotic process regulation of stem cell population maintenance cell death negative regulation of stem cell population maintenance negative regulation of apoptotic process involved in development negative regulation of apoptotic process regulation of apoptotic process involved in morphogenesis negative regulation of somatic stem cell population maintenance maintenance of cell number negative regulation of multicellular organismal process apoptotic process involved in morphogenesis nephron morphogenesis regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis apoptotic process involved in development negative regulation of apoptotic process involved in morphogenesis mesenchymal cell apoptotic process regulation of apoptotic process involved in development kidney morphogenesis mesenchymal stem cell maintenance involved in nephron morphogenesis apoptotic process programmed cell death positive regulation of locomotion regulation of cell motility heart morphogenesis cardiac neural crest cell development involved in heart development neural crest cell development mesenchyme development mesenchymal cell migration positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis positive regulation of cell migration cell migration neural crest cell migration neural crest cell differentiation stem cell differentiation cardiac neural crest cell differentiation involved in heart development regulation of locomotion outflow tract morphogenesis cardiac neural crest cell migration involved in outflow tract morphogenesis cell development ameboidal-type cell migration positive regulation of cell motility regulation of cell migration cell motility locomotion stem cell development cardiac neural crest cell development involved in outflow tract morphogenesis heart development cell migration involved in heart development cardiocyte differentiation regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis mesenchymal cell differentiation cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of cellular biosynthetic process response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus cellular response to stress response to hypoxia response to stress response to chemical response to oxygen levels response to abiotic stimulus mesonephros development negative regulation of cell cycle cell cycle regulation of cell cycle positive regulation of programmed cell death positive regulation of apoptotic process mesenchyme morphogenesis nephrogenic mesenchyme development kidney mesenchyme development nephrogenic mesenchyme morphogenesis kidney mesenchyme morphogenesis regulation of biomineral tissue development regulation of bone mineralization positive regulation of ossification positive regulation of biomineral tissue development ossification biomineral tissue development bone mineralization positive regulation of bone mineralization positive regulation of multicellular organismal process regulation of ossification endocardial cushion morphogenesis endocardial cushion formation endocardial cushion development kidney mesenchymal cell proliferation metanephric mesenchyme development metanephric mesenchymal cell proliferation involved in metanephros development metanephros development cell proliferation involved in metanephros development mesenchymal cell proliferation monocyte aggregation cell adhesion cell-cell adhesion leukocyte cell-cell adhesion leukocyte aggregation pharyngeal system development cardiac chamber morphogenesis cardiac septum development cardiac septum morphogenesis cardiac chamber development placenta development chorio-allantoic fusion labyrinthine layer development in utero embryonic development embryonic placenta morphogenesis labyrinthine layer morphogenesis embryonic placenta development embryonic organ development epithelial to mesenchymal transition positive regulation of cell adhesion regulation of cell adhesion positive regulation of cell-cell adhesion heterotypic cell-cell adhesion positive regulation of heterotypic cell-cell adhesion regulation of cell-cell adhesion regulation of heterotypic cell-cell adhesion sensory organ development embryonic eye morphogenesis visual system development embryonic camera-type eye development eye morphogenesis sensory system development embryonic organ morphogenesis camera-type eye morphogenesis eye development embryonic camera-type eye morphogenesis sensory organ morphogenesis camera-type eye development cardiac muscle tissue development striated muscle tissue development muscle tissue development regulation of neurogenesis regulation of cell development regulation of nervous system development negative regulation of neurogenesis negative regulation of nervous system development negative regulation of cell development pericardium morphogenesis morphogenesis of an epithelial sheet pericardium development regulation of primary metabolic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process primary metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA biosynthetic process formation of primary germ layer mesoderm morphogenesis gastrulation mesoderm formation mesoderm development negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process cellular response to BMP stimulus cellular response to growth factor stimulus response to endogenous stimulus cellular response to endogenous stimulus response to BMP transforming growth factor beta receptor superfamily signaling pathway response to growth factor BMP signaling pathway response to organic substance response to hormone response to organonitrogen compound response to peptide hormone response to oxygen-containing compound response to nitrogen compound hyaluranon cable assembly positive regulation of cellular component organization regulation of cellular component organization positive regulation of cellular component biogenesis regulation of cellular component biogenesis cellular component biogenesis cellular component organization cellular component assembly positive regulation of hyaluranon cable assembly cellular component organization or biogenesis regulation of hyaluranon cable assembly cellular response to oxidative stress detoxification regulation of cellular response to stress reactive oxygen species metabolic process cellular response to chemical stress regulation of cellular response to oxidative stress response to superoxide cellular oxidant detoxification response to inorganic substance cellular response to oxygen radical cellular response to reactive oxygen species regulation of response to stress regulation of response to oxidative stress cellular detoxification regulation of superoxide metabolic process cellular response to oxygen-containing compound response to reactive oxygen species regulation of removal of superoxide radicals response to toxic substance superoxide metabolic process removal of superoxide radicals response to oxidative stress regulation of response to reactive oxygen species cellular response to superoxide regulation of reactive oxygen species metabolic process cellular response to toxic substance response to oxygen radical embryonic skeletal joint development embryonic skeletal joint morphogenesis embryonic skeletal system development skeletal system morphogenesis embryonic skeletal system morphogenesis odontogenesis of dentin-containing tooth odontogenesis regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition heart trabecula morphogenesis trabecula morphogenesis regulation of reproductive process prostate gland epithelium morphogenesis gland morphogenesis reproductive structure development animal organ formation regulation of morphogenesis of a branching structure regulation of animal organ morphogenesis prostatic bud formation urogenital system development prostate gland morphogenesis prostate gland development reproductive process gland development lateral sprouting from an epithelium developmental process involved in reproduction negative regulation of prostatic bud formation regulation of morphogenesis of an epithelium morphogenesis of an epithelial bud regulation of anatomical structure morphogenesis reproductive system development regulation of prostatic bud formation negative regulation of reproductive process regulation of animal organ formation negative regulation of morphogenesis of an epithelium limb development appendage development embryonic limb morphogenesis embryonic appendage morphogenesis appendage morphogenesis limb morphogenesis cell projection organization plasma membrane bounded cell projection morphogenesis neuron projection development cell morphogenesis cell projection morphogenesis neuron projection morphogenesis plasma membrane bounded cell projection organization neuron development negative regulation of DNA-binding transcription factor activity negative regulation of NF-kappaB transcription factor activity negative regulation of molecular function regulation of molecular function regulation of DNA-binding transcription factor activity negative regulation of signaling negative regulation of cell communication negative regulation of response to stimulus negative regulation of signal transduction Notch signaling pathway negative regulation of Notch signaling pathway regulation of Notch signaling pathway metanephric mesenchyme morphogenesis muscle cell apoptotic process regulation of muscle cell apoptotic process regulation of striated muscle cell apoptotic process striated muscle cell apoptotic process negative regulation of muscle cell apoptotic process negative regulation of striated muscle cell apoptotic process ureteric bud development mesonephric epithelium development kidney epithelium development mesonephric tubule development dendrite development positive regulation of neuron differentiation axonogenesis axon guidance axon development cell morphogenesis involved in neuron differentiation neuron projection guidance regulation of osteoblast differentiation osteoblast differentiation positive regulation of osteoblast differentiation fat cell differentiation positive regulation of brown fat cell differentiation positive regulation of fat cell differentiation regulation of brown fat cell differentiation brown fat cell differentiation regulation of fat cell differentiation response to nutrient levels response to vitamin D response to lipid response to nutrient response to vitamin response to organic cyclic compound regulation of neuron projection development positive regulation of neuron projection development positive regulation of cell projection organization regulation of cell projection organization positive regulation of dendrite development regulation of dendrite development regulation of plasma membrane bounded cell projection organization negative regulation of intracellular signal transduction regulation of non-canonical NF-kappaB signal transduction negative regulation of non-canonical NF-kappaB signal transduction non-canonical NF-kappaB signal transduction embryonic pattern specification pattern specification process branching involved in salivary gland morphogenesis salivary gland development salivary gland morphogenesis exocrine system development regulation of mitotic nuclear division mitotic cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle cell cycle process mitotic nuclear division negative regulation of cellular component organization regulation of cell cycle process organelle fission negative regulation of cell cycle process regulation of organelle organization organelle organization nuclear division mitotic cell cycle process negative regulation of nuclear division negative regulation of organelle organization regulation of nuclear division negative regulation of mitotic nuclear division regulation of branching involved in prostate gland morphogenesis branching involved in prostate gland morphogenesis ameloblast differentiation columnar/cuboidal epithelial cell differentiation response to estradiol	cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix cellular anatomical entity extracellular region extracellular space membrane-bounded organelle organelle vesicle
B [auth A]	Noggin	protein binding binding cytokine binding identical protein binding protein homodimerization activity protein dimerization activity	developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development cellular response to stimulus regulation of cellular process response to stimulus signaling developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development cellular response to stimulus regulation of cellular process response to stimulus signaling negative regulation of signaling regulation of signaling receptor activity negative regulation of biological process negative regulation of cytokine activity regulation of signal transduction negative regulation of cell communication cell communication regulation of protein binding regulation of cytokine activity negative regulation of cellular process signal transduction regulation of biological process regulation of signaling negative regulation of response to stimulus regulation of binding negative regulation of binding biological regulation negative regulation of molecular function negative regulation of signal transduction negative regulation of receptor binding regulation of molecular function regulation of receptor binding negative regulation of protein binding regulation of response to stimulus regulation of cell communication cellular process heart development cardiac chamber morphogenesis heart morphogenesis ventricular septum development circulatory system development anatomical structure morphogenesis cardiac septum development cardiac septum morphogenesis ventricular septum morphogenesis cardiac chamber development animal organ morphogenesis cardiac ventricle development behavior exploration behavior trans-synaptic signaling modulation of chemical synaptic transmission cell-cell signaling presynaptic modulation of chemical synaptic transmission chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling tube development respiratory tube development lung morphogenesis lung development respiratory system development regulation of developmental process positive regulation of biological process regulation of kidney development positive regulation of glomerulus development positive regulation of kidney development renal system development positive regulation of developmental process glomerulus development regulation of glomerulus development positive regulation of multicellular organismal process regulation of multicellular organismal process nephron development kidney development cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process dorsal/ventral pattern formation pattern specification process regionalization cardiac atrium morphogenesis striated muscle tissue development muscle structure development muscle tissue development muscle organ development atrial cardiac muscle tissue morphogenesis cardiac muscle tissue development cardiac atrium development atrial cardiac muscle tissue development muscle tissue morphogenesis tissue morphogenesis cardiac muscle tissue morphogenesis muscle organ morphogenesis embryonic organ morphogenesis embryonic morphogenesis notochord morphogenesis embryo development embryonic organ development notochord development regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway negative regulation of Wnt signaling pathway Wnt signaling pathway cell surface receptor signaling pathway regulation of Wnt signaling pathway negative regulation of canonical Wnt signaling pathway membranous septum morphogenesis regulation of growth regulation of cardiac muscle tissue growth developmental growth cardiac muscle cell proliferation negative regulation of cardiac muscle tissue growth organ growth negative regulation of organ growth negative regulation of growth regulation of organ growth regulation of heart growth regulation of cardiac muscle cell proliferation muscle cell proliferation cardiac muscle tissue growth striated muscle cell proliferation negative regulation of cell population proliferation heart growth regulation of multicellular organismal development cell population proliferation regulation of developmental growth negative regulation of heart growth negative regulation of developmental process growth negative regulation of developmental growth regulation of cell population proliferation negative regulation of multicellular organismal process negative regulation of cardiac muscle cell proliferation mesenchyme morphogenesis endocardial cushion morphogenesis mesenchyme development endocardial cushion formation endocardial cushion development anatomical structure formation involved in morphogenesis cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of cellular response to growth factor stimulus negative regulation of BMP signaling pathway cellular response to endogenous stimulus BMP signaling pathway enzyme-linked receptor protein signaling pathway cellular response to BMP stimulus regulation of BMP signaling pathway response to endogenous stimulus regulation of cellular response to growth factor stimulus response to BMP transforming growth factor beta receptor superfamily signaling pathway response to growth factor negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway head development forebrain development endocrine system development pituitary gland development gland development brain development diencephalon development nervous system development central nervous system development embryo development ending in birth or egg hatching chordate embryonic development in utero embryonic development negative regulation of intracellular signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette SMAD protein signal transduction regulation of SMAD protein signal transduction negative regulation of SMAD protein signal transduction embryonic epithelial tube formation tube formation epithelial tube formation tube morphogenesis primary neural tube formation epithelial tube morphogenesis morphogenesis of embryonic epithelium epithelium development neural tube development morphogenesis of an epithelium neural tube closure neural tube formation tube closure neural plate development neural plate morphogenesis limb development appendage development regulation of neuronal synaptic plasticity regulation of synaptic plasticity regulation of biological quality cellular developmental process cell differentiation mesenchymal cell differentiation epithelial to mesenchymal transition negative regulation of locomotion regulation of cell motility regulation of locomotion regulation of cell migration negative regulation of cell motility cell migration cell motility negative regulation of cell migration locomotion embryonic skeletal system development prostate gland development reproductive process lateral sprouting from an epithelium developmental process involved in reproduction prostate gland epithelium morphogenesis gland morphogenesis reproductive structure development morphogenesis of an epithelial bud animal organ formation morphogenesis of an epithelial fold reproductive system development prostatic bud formation urogenital system development prostate gland morphogenesis morphogenesis of a branching structure morphogenesis of a branching epithelium short-term synaptic potentiation somatic stem cell population maintenance maintenance of cell number stem cell population maintenance negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process primary metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process negative regulation of biosynthetic process blood vessel morphogenesis artery development pharyngeal arch artery morphogenesis vasculature development pharyngeal system development artery morphogenesis blood vessel development positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process formation of primary germ layer mesoderm morphogenesis gastrulation mesoderm formation mesoderm development ear morphogenesis middle ear morphogenesis ear development sensory organ development sensory organ morphogenesis mesonephric epithelium development kidney epithelium development nephron morphogenesis nephron tubule morphogenesis nephron epithelium morphogenesis nephron tubule development ureteric bud morphogenesis nephron tubule formation renal tubule development nephron epithelium development ureteric bud development mesonephros development mesonephric tubule formation kidney morphogenesis mesonephric tubule morphogenesis ureteric bud formation mesonephric tubule development renal tubule morphogenesis astrocyte differentiation cell development regulation of cell differentiation regulation of neurogenesis regulation of astrocyte differentiation regulation of gliogenesis regulation of cell development regulation of nervous system development neurogenesis negative regulation of neurogenesis gliogenesis negative regulation of nervous system development negative regulation of cell differentiation regulation of glial cell differentiation negative regulation of astrocyte differentiation negative regulation of gliogenesis negative regulation of cell development negative regulation of glial cell differentiation glial cell differentiation ossification osteoblast differentiation spinal cord development response to fibroblast growth factor cell surface receptor protein tyrosine kinase signaling pathway fibroblast growth factor receptor signaling pathway cellular response to fibroblast growth factor stimulus regulation of fibroblast growth factor receptor signaling pathway smoothened signaling pathway activin receptor signaling pathway nodal signaling pathway branching morphogenesis of an epithelial tube regulation of branching involved in ureteric bud morphogenesis regulation of morphogenesis of a branching structure regulation of animal organ morphogenesis positive regulation of morphogenesis of an epithelium branching involved in ureteric bud morphogenesis regulation of morphogenesis of an epithelium regulation of anatomical structure morphogenesis positive regulation of branching involved in ureteric bud morphogenesis embryonic skeletal joint development embryonic skeletal joint morphogenesis skeletal system morphogenesis embryonic skeletal system morphogenesis face morphogenesis head morphogenesis face development body morphogenesis cranial skeletal system development regulation of osteoblast differentiation negative regulation of osteoblast differentiation heart trabecula morphogenesis trabecula morphogenesis neural plate pattern specification neural plate regionalization anterior/posterior pattern specification neural plate anterior/posterior regionalization axonogenesis cell projection organization motor neuron axon guidance plasma membrane bounded cell projection morphogenesis neuron projection development cell morphogenesis cellular component organization cell projection morphogenesis neuron differentiation neuron projection morphogenesis cellular component organization or biogenesis plasma membrane bounded cell projection organization axon guidance axon development cell morphogenesis involved in neuron differentiation generation of neurons neuron projection guidance neuron development positive regulation of cell population proliferation positive regulation of epithelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation response to light stimulus system process learning learning or memory nervous system process visual learning visual behavior cognition associative learning response to radiation response to abiotic stimulus regulation of epithelial to mesenchymal transition cardiac epithelial to mesenchymal transition regulation of cardiac epithelial to mesenchymal transition negative regulation of epithelial to mesenchymal transition negative regulation of cardiac epithelial to mesenchymal transition axial mesoderm development regulation of programmed cell death negative regulation of apoptotic signaling pathway negative regulation of programmed cell death regulation of apoptotic process cell death apoptotic signaling pathway negative regulation of apoptotic process apoptotic process programmed cell death regulation of apoptotic signaling pathway wound healing response to stress response to wounding endoderm development endoderm formation regulation of cartilage development negative regulation of cartilage development negative regulation of gene expression stem cell differentiation ventricular cardiac muscle tissue morphogenesis ventricular cardiac muscle tissue development ventricular compact myocardium morphogenesis cardiac ventricle morphogenesis hindbrain development cell differentiation in hindbrain positive regulation of cell communication long-term synaptic potentiation positive regulation of synaptic transmission positive regulation of signaling embryonic limb morphogenesis embryonic appendage morphogenesis appendage morphogenesis embryonic digit morphogenesis limb morphogenesis outflow tract morphogenesis somite development	extracellular region extracellular space cellular anatomical entity presynapse synapse cell junction

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth L]	IPR029034	Cystine-knot cytokine	Homologous Superfamily
A [auth L]	IPR017948	Transforming growth factor beta, conserved site	Conserved Site
A [auth L]	IPR001839	Transforming growth factor-beta, C-terminal	Domain
A [auth L]	IPR015615	Transforming growth factor-beta-related	Family
A [auth L]	IPR001111	TGF-beta, propeptide	Domain
B [auth A]	IPR029034	Cystine-knot cytokine	Homologous Superfamily
B [auth A]	IPR008717	Noggin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth L]	Pharos: P18075	prostate cancer pulmonary fibrosis endometriosis Liver Cirrhosis, Experimental interstitial cystitis major depressive disorder medulloblastoma osteosarcoma atypical teratoid rhabdoid tumor bone resorption disease gastric neoplasm hereditary diffuse gastric adenocarcinoma malignant ependymoma non-small cell lung carcinoma ovarian cancer prostate cancer pulmonary fibrosis endometriosis Liver Cirrhosis, Experimental interstitial cystitis major depressive disorder medulloblastoma osteosarcoma atypical teratoid rhabdoid tumor bone resorption disease gastric neoplasm hereditary diffuse gastric adenocarcinoma malignant ependymoma non-small cell lung carcinoma ovarian cancer bone fracture coloboma cutaneous lupus erythematosus esophageal adenocarcinoma glioblastoma idiopathic interstitial pneumonia lung cancer oligodendroglioma pilocytic astrocytoma psoriasis colorectal cancer gastric cancer
B [auth A]	Pharos: Q13253	tarsal-carpal coalition syndrome brachydactyly type B2 multiple synostoses syndrome 1 proximal symphalangism stapes ankylosis with broad thumbs and toes proximal symphalangism 1A calcaneonavicular coalition multiple synostoses syndrome atypical teratoid rhabdoid tumor intellectual disability MALT lymphoma osteosarcoma sarcoidosis large cell medulloblastoma medulloblastoma tarsal-carpal coalition syndrome brachydactyly type B2 multiple synostoses syndrome 1 proximal symphalangism stapes ankylosis with broad thumbs and toes proximal symphalangism 1A calcaneonavicular coalition multiple synostoses syndrome atypical teratoid rhabdoid tumor intellectual disability MALT lymphoma osteosarcoma sarcoidosis large cell medulloblastoma medulloblastoma NOG-Related-Symphalangism Spectrum Disorder malignant glioma oligodendroglioma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.