1M4B

Crystal Structure of Human Interleukin-2 K43C Covalently Modified at C43 with 2-[2-(2-Cyclohexyl-2-guanidino-acetylamino)-acetylamino]-N-(3-mercapto-propyl)-propionamide

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1m4ba_	All alpha proteins	4-helical cytokines	4-helical cytokines	Short-chain cytokines	Interleukin-2 (IL-2)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	4-helical cytokines	8037109	3001717	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	IL2	e1m4bA1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: 4-helical cytokines (From Topology)	T: 4-helical cytokines	F: IL2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1250.10	Mainly Alpha	Up-down Bundle	Growth Hormone	Chain: A	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A	Interleukin-2	IL2	Homo sapiens (human)	IL2	R-LIKE-DOMAIN IL2 (Pr21-153)	RPI	IL2	IMGT (202415-0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00715	Interleukin 2 (IL2)	Interleukin 2	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	interleukin-2	protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity enzyme regulator activity kinase activator activity enzyme activator activity kinase regulator activity kappa-type opioid receptor binding protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity enzyme regulator activity kinase activator activity enzyme activator activity kinase regulator activity kappa-type opioid receptor binding G protein-coupled receptor binding opioid receptor binding cytokine receptor binding growth factor receptor binding interleukin-2 receptor binding glycosphingolipid binding sphingolipid binding lipid binding glycolipid binding carbohydrate derivative binding carbohydrate binding cytokine activity	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains response to stimulus regulation of leukocyte activation regulation of cell activation B cell activation involved in immune response positive regulation of macromolecule biosynthetic process regulation of primary metabolic process multicellular organism development positive regulation of immune response organic substance biosynthetic process regulation of immune system process positive regulation of macromolecule metabolic process system development positive regulation of DNA recombination adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains response to stimulus regulation of leukocyte activation regulation of cell activation B cell activation involved in immune response positive regulation of macromolecule biosynthetic process regulation of primary metabolic process multicellular organism development positive regulation of immune response organic substance biosynthetic process regulation of immune system process positive regulation of macromolecule metabolic process system development positive regulation of DNA recombination positive regulation of immunoglobulin mediated immune response immune response cellular metabolic process DNA recombination primary metabolic process DNA metabolic process immune effector process regulation of gene expression biosynthetic process positive regulation of DNA metabolic process regulation of response to stimulus B cell mediated immunity positive regulation of production of molecular mediator of immune response regulation of macromolecule biosynthetic process metabolic process regulation of DNA metabolic process immunoglobulin production regulation of developmental process positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains somatic cell DNA recombination positive regulation of cellular metabolic process somatic diversification of immunoglobulins involved in immune response positive regulation of lymphocyte activation somatic recombination of immunoglobulin gene segments positive regulation of biosynthetic process regulation of immunoglobulin mediated immune response leukocyte activation involved in immune response regulation of B cell activation positive regulation of isotype switching positive regulation of immune effector process positive regulation of cellular process production of molecular mediator of immune response positive regulation of immunoglobulin production regulation of isotype switching cell activation regulation of macromolecule metabolic process macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of gene expression immune system process somatic diversification of immune receptors via germline recombination within a single locus cellular process positive regulation of cellular biosynthetic process regulation of lymphocyte activation lymphocyte mediated immunity regulation of immune effector process multicellular organismal process regulation of DNA recombination positive regulation of leukocyte mediated immunity regulation of cellular process cell activation involved in immune response nucleobase-containing compound metabolic process positive regulation of developmental process positive regulation of cell activation positive regulation of metabolic process anatomical structure development positive regulation of leukocyte activation leukocyte mediated immunity somatic diversification of immune receptors regulation of nucleobase-containing compound metabolic process positive regulation of adaptive immune response positive regulation of immune system process somatic recombination of immunoglobulin genes involved in immune response developmental process regulation of biological process positive regulation of nucleobase-containing compound metabolic process regulation of adaptive immune response regulation of cellular metabolic process regulation of B cell mediated immunity somatic diversification of immunoglobulins organic cyclic compound metabolic process regulation of leukocyte mediated immunity regulation of immune response positive regulation of multicellular organismal process regulation of production of molecular mediator of immune response macromolecule metabolic process regulation of metabolic process isotype switching immune system development immunoglobulin production involved in immunoglobulin-mediated immune response positive regulation of lymphocyte mediated immunity cellular biosynthetic process positive regulation of biological process lymphocyte activation positive regulation of B cell mediated immunity leukocyte activation positive regulation of response to stimulus regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains organic substance metabolic process positive regulation of isotype switching to IgG isotypes regulation of multicellular organismal process lymphocyte activation involved in immune response regulation of biosynthetic process B cell activation biological regulation gene expression adaptive immune response immunoglobulin mediated immune response positive regulation of B cell activation regulation of isotype switching to IgG isotypes regulation of lymphocyte mediated immunity regulation of immunoglobulin production isotype switching to IgG isotypes regulation of defense response regulation of response to external stimulus defense response response to external stimulus regulation of inflammatory response positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stress response to stress positive regulation of defense response inflammatory response regulation of protein modification process regulation of protein phosphorylation negative regulation of biological process negative regulation of phosphate metabolic process negative regulation of cellular metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process negative regulation of cellular process protein metabolic process protein modification process phosphorus metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of metabolic process negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process negative regulation of phosphorylation signaling cell-cell signaling cell communication regulation of leukocyte differentiation mononuclear cell differentiation regulation of cell differentiation mature B cell differentiation positive regulation of B cell differentiation lymphocyte differentiation regulation of cell development regulation of plasma cell differentiation cell differentiation positive regulation of cell development positive regulation of plasma cell differentiation plasma cell differentiation leukocyte differentiation cellular developmental process cell development regulation of B cell differentiation B cell differentiation positive regulation of hemopoiesis positive regulation of cell differentiation regulation of lymphocyte differentiation regulation of multicellular organismal development mature B cell differentiation involved in immune response hemopoiesis regulation of hemopoiesis positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation cell projection organization positive regulation of dendritic spine development regulation of dendritic spine development neuron projection development cellular component organization neurogenesis neuron differentiation dendrite development cellular component organization or biogenesis dendritic spine development plasma membrane bounded cell projection organization nervous system development generation of neurons neuron development T cell activation T cell differentiation cellular response to stimulus signal transduction in absence of ligand cell surface receptor signaling pathway cell death extrinsic apoptotic signaling pathway apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand signal transduction apoptotic process programmed cell death positive regulation of tissue remodeling tissue remodeling regulation of tissue remodeling natural killer cell activation cell adhesion homeostatic process T cell homeostatic proliferation leukocyte proliferation T cell homeostasis lymphocyte proliferation T cell proliferation regulation of lymphocyte proliferation regulation of leukocyte proliferation cell population proliferation regulation of T cell activation regulation of T cell proliferation multicellular organismal-level homeostasis regulation of T cell homeostatic proliferation leukocyte homeostasis regulation of cell population proliferation mononuclear cell proliferation regulation of mononuclear cell proliferation homeostasis of number of cells lymphocyte homeostasis positive regulation of cell population proliferation positive regulation of B cell proliferation regulation of B cell proliferation positive regulation of mononuclear cell proliferation positive regulation of lymphocyte proliferation B cell proliferation positive regulation of leukocyte proliferation DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process positive regulation of RNA biosynthetic process regulation of leukocyte apoptotic process regulation of lymphocyte apoptotic process regulation of B cell apoptotic process negative regulation of programmed cell death leukocyte apoptotic process regulation of apoptotic process B cell apoptotic process regulation of programmed cell death negative regulation of B cell apoptotic process lymphocyte apoptotic process negative regulation of apoptotic process negative regulation of leukocyte apoptotic process negative regulation of lymphocyte apoptotic process regulation of growth regulation of cellular component organization growth positive regulation of cell growth regulation of cell growth cell growth positive regulation of growth positive regulation of cytosolic calcium ion concentration regulation of biological quality regulation of alpha-beta T cell activation regulation of alpha-beta T cell proliferation alpha-beta T cell proliferation CD4-positive, alpha-beta T cell activation alpha-beta T cell activation CD4-positive, alpha-beta T cell proliferation regulation of CD4-positive, alpha-beta T cell proliferation regulation of CD4-positive, alpha-beta T cell activation response to organic substance interleukin-2-mediated signaling pathway cellular response to interleukin-2 response to cytokine cytokine-mediated signaling pathway response to interleukin-2 cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to organic substance positive regulation of T cell differentiation positive regulation of T cell activation positive regulation of regulatory T cell differentiation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte cell-cell adhesion leukocyte cell-cell adhesion positive regulation of cell-cell adhesion regulation of T cell differentiation cell-cell adhesion regulation of cell-cell adhesion positive regulation of cell adhesion regulation of cell adhesion regulation of regulatory T cell differentiation regulatory T cell differentiation negative regulation of inflammatory response negative regulation of response to stimulus negative regulation of response to external stimulus negative regulation of defense response protein kinase C-activating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway response to alcohol response to oxygen-containing compound response to ethanol negative regulation of lymphocyte proliferation negative regulation of lymphocyte activation negative regulation of mononuclear cell proliferation negative regulation of leukocyte proliferation negative regulation of cell population proliferation negative regulation of cell activation negative regulation of immune system process negative regulation of multicellular organismal process negative regulation of leukocyte activation positive regulation of T cell proliferation positive regulation of activated T cell proliferation regulation of activated T cell proliferation activated T cell proliferation response to tacrolimus response to organonitrogen compound response to nitrogen compound response to organic cyclic compound positive regulation of phosphorylation positive regulation of phosphate metabolic process peptidyl-amino acid modification positive regulation of protein phosphorylation tyrosine phosphorylation of STAT protein positive regulation of phosphorus metabolic process cell surface receptor signaling pathway via STAT positive regulation of protein metabolic process peptidyl-tyrosine modification positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process regulation of tyrosine phosphorylation of STAT protein regulation of peptidyl-tyrosine phosphorylation positive regulation of tyrosine phosphorylation of STAT protein peptidyl-tyrosine phosphorylation cell surface receptor signaling pathway via JAK-STAT cytokine production regulation of cytokine production interleukin-17 production regulation of interleukin-17 production positive regulation of interleukin-17 production positive regulation of cytokine production alpha-beta T cell differentiation involved in immune response negative regulation of cell adhesion negative regulation of T cell differentiation regulation of T-helper cell differentiation T-helper cell differentiation negative regulation of leukocyte differentiation negative regulation of immune effector process negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion negative regulation of cell-cell adhesion T-helper 17 cell differentiation negative regulation of T-helper 17 cell differentiation CD4-positive, alpha-beta T cell differentiation alpha-beta T cell differentiation T cell activation involved in immune response negative regulation of cell differentiation regulation of T-helper 17 cell differentiation negative regulation of developmental process negative regulation of T-helper 17 type immune response negative regulation of cell development negative regulation of alpha-beta T cell activation CD4-positive, alpha-beta T cell differentiation involved in immune response negative regulation of hemopoiesis negative regulation of immune response negative regulation of adaptive immune response negative regulation of CD4-positive, alpha-beta T cell activation negative regulation of lymphocyte differentiation negative regulation of CD4-positive, alpha-beta T cell differentiation regulation of CD4-positive, alpha-beta T cell differentiation regulation of alpha-beta T cell differentiation negative regulation of alpha-beta T cell differentiation alpha-beta T cell activation involved in immune response regulation of T-helper 17 type immune response T cell differentiation involved in immune response negative regulation of T-helper cell differentiation T-helper 17 type immune response regulation of type II interferon production type II interferon production positive regulation of type II interferon production	extracellular region extracellular space cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000779	Interleukin-2	Family
A	IPR030477	Interleukin-2, conserved site	Conserved Site
A	IPR009079	Four-helical cytokine-like, core	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P60568	cancer leukopenia glomerulonephritis autoimmune hepatitis adult T-cell leukemia/lymphoma glioblastoma melanoma nephrotic syndrome Neoplasms, Experimental allergic contact dermatitis dissociative amnesia alopecia areata rheumatoid arthritis giant cell glioblastoma liver cancer cancer leukopenia glomerulonephritis autoimmune hepatitis adult T-cell leukemia/lymphoma glioblastoma melanoma nephrotic syndrome Neoplasms, Experimental allergic contact dermatitis dissociative amnesia alopecia areata rheumatoid arthritis giant cell glioblastoma liver cancer anemia leukemia prostate cancer AIDS major depressive disorder HIV infectious disease asthma urinary bladder cancer autoimmune disease neutropenia influenza paranoid schizophrenia kidney disease pneumonia adult acute respiratory distress syndrome COVID-19 liver neoplasm lymphatic system disease arthritic joint disease autism urinary bladder neoplasm inborn carbohydrate metabolic disorder brain cancer brain injury juvenile idiopathic arthritis peripheral nervous system disease kidney neoplasm cutaneous melanoma lung benign neoplasm allergic disease lymphopenia schizophrenia systemic lupus erythematosus tuberculosis vaginal cancer hypotensive disorder benign neoplasm inflammatory bowel disease kidney cancer peripheral neuropathy breast disease acute T cell leukemia celiac disease liver disease diarrheal disease endogenous depression allergic rhinitis amnestic disorder skin disease

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.