1M1H

Crystal structure of Aquifex aeolicus N-utilization substance G (NusG), Space group I222

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1m1ha1	All beta proteins	N-utilization substance G protein NusG, insert domain	N-utilization substance G protein NusG, insert domain	N-utilization substance G protein NusG, insert domain	N-utilization substance G protein NusG, insert domain	(Aquifex aeolicus ) [TaxId: 63363 ],	SCOPe (2.08)
A	d1m1ha2	Alpha and beta proteins (a+b)	Ferredoxin-like	N-utilization substance G protein NusG, N-terminal domain	N-utilization substance G protein NusG, N-terminal domain	N-utilization substance G protein NusG, N-terminal domain	(Aquifex aeolicus ) [TaxId: 63363 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	N-utilization substance G protein NusG insert domain	8030807	4002500	SCOP2 (2022-06-29)
A	SCOP2 Family	N-utilization substance G protein NusG N-terminal domain-like	8030810	4003239	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	N-utilization substance G protein NusG insert domain	8043186	3001341	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	N-utilization substance G protein NusG N-terminal domain	8043189	3000474	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF07009	e1m1hA1	A: beta sandwiches	X: N-utilization substance G protein NusG, insert domain (From Topology)	H: N-utilization substance G protein NusG, insert domain (From Topology)	T: N-utilization substance G protein NusG, insert domain	F: PF07009	ECOD (1.6)
A	PF02357	e1m1hA2	A: a+b two layers	X: Alpha-beta plaits	H: N-utilization substance G protein NusG, N-terminal domain (From Topology)	T: N-utilization substance G protein NusG, N-terminal domain	F: PF02357	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.70.940	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	NusG, N-terminal domain	CATH (4.3.0)
A	2.60.320.10	Mainly Beta	Sandwich	mini-chromosome maintenance (MCM) complex, domain 2	N-utilization substance G protein NusG, insert domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02357	Transcription termination factor nusG (NusG)	Transcription termination factor nusG	-	Domain
A	PF07009	NusG domain II (NusG_II)	NusG domain II	This domain is found in some NusG proteins where it forms domain II [1]. However most NusG proteins are missing this domain. In other cases this domain is found in isolation [2]. The function of this domain is unknown.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Transcription antitermination protein nusG	-	negative regulation of termination of DNA-templated transcription regulation of cellular process negative regulation of biological process protein-containing complex disassembly positive regulation of macromolecule biosynthetic process regulation of protein-containing complex disassembly negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of termination of DNA-templated transcription regulation of cellular process negative regulation of biological process protein-containing complex disassembly positive regulation of macromolecule biosynthetic process regulation of protein-containing complex disassembly negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process cellular component disassembly negative regulation of DNA-templated transcription regulation of biological process negative regulation of cellular component organization cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process primary metabolic process negative regulation of cellular biosynthetic process regulation of gene expression organic cyclic compound metabolic process biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process regulation of termination of DNA-templated transcription regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process regulation of cellular component organization transcription antitermination cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process DNA-templated transcription termination RNA biosynthetic process cellular component organization nucleic acid biosynthetic process organic substance metabolic process positive regulation of biosynthetic process negative regulation of protein-containing complex disassembly negative regulation of cellular process cellular component organization or biogenesis positive regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process protein-containing complex organization biological regulation regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of gene expression negative regulation of biosynthetic process cellular process positive regulation of cellular biosynthetic process transcription elongation by RNA polymerase II protein-DNA complex organization transcription by RNA polymerase II chromatin organization chromatin remodeling transcription elongation-coupled chromatin remodeling DNA-templated transcription elongation regulation of DNA-templated transcription elongation	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR043425	NusG-like	Family
A	IPR001062	Transcription antitermination protein, NusG	Family
A	IPR036735	NusG, N-terminal domain superfamily	Homologous Superfamily
A	IPR038690	NusG, domain 2 superfamily	Homologous Superfamily
A	IPR014722	Large ribosomal subunit protein uL2, domain 2	Homologous Superfamily
A	IPR015869	Transcription antitermination protein, NusG, bacteria, conserved site	Conserved Site
A	IPR008991	Translation protein SH3-like domain superfamily	Homologous Superfamily
A	IPR047050	NusG, N-terminal	Domain
A	IPR024045	NusG, domain 2	Domain
A	IPR005824	KOW	Domain
A	IPR006645	NusG-like, N-terminal	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.