1LK3
ENGINEERED HUMAN INTERLEUKIN-10 MONOMER COMPLEXED TO 9D7 FAB FRAGMENT
External Resource: Annotation
- Domain Annotation: SCOP/SCOPe Classification
- Domain Annotation: SCOP2 Classification
- Domain Annotation: ECOD Classification
- Domain Annotation: CATH
- IMGT Antibody Annotation
- SAbDab Antibody Annotation
- Protein Family Annotation
- Gene Ontology: Gene Product Annotation
- InterPro: Protein Family Classification
- Pharos: Disease Associations
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
D [auth B] | SCOP2B Superfamily | 4-helical cytokines | 8037111 | 3001717 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | 4-helical cytokines | 8037111 | 3001717 | SCOP2B (2022-06-29) |
B [auth L] | SCOP2 Family | Antibody constant domains | 8070448 | 4007745 | SCOP2 (2022-06-29) |
B [auth L] | SCOP2 Family | Antibody variable domains | 8091534 | 4007744 | SCOP2 (2022-06-29) |
B [auth L] | SCOP2 Superfamily | Immunoglobulin (Ig) domain-like | 8070449 | 3000071 | SCOP2 (2022-06-29) |
B [auth L] | SCOP2 Superfamily | Immunoglobulin (Ig) domain-like | 8091535 | 3000071 | SCOP2 (2022-06-29) |
E [auth M] | SCOP2B Superfamily | Immunoglobulin (Ig) domain-like | 8070449 | 3000071 | SCOP2B (2022-06-29) |
F [auth I] | SCOP2B Superfamily | Immunoglobulin (Ig) domain-like | 8070455 | 3000071 | SCOP2B (2022-06-29) |
C [auth H] | SCOP2 Family | Antibody constant domains | 8070454 | 4007745 | SCOP2 (2022-06-29) |
C [auth H] | SCOP2 Family | Antibody variable domains | 8091537 | 4007744 | SCOP2 (2022-06-29) |
C [auth H] | SCOP2 Superfamily | Immunoglobulin (Ig) domain-like | 8070455 | 3000071 | SCOP2 (2022-06-29) |
C [auth H] | SCOP2 Superfamily | Immunoglobulin (Ig) domain-like | 8091536 | 3000071 | SCOP2 (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
D [auth B] | PF00726 | e1lk3B1 | A: alpha bundles | X: Ferritin/Heme oxygenase/4-helical cytokines | H: 4-helical cytokines (From Topology) | T: 4-helical cytokines | F: PF00726 | ECOD (1.6) |
A | PF00726 | e1lk3A1 | A: alpha bundles | X: Ferritin/Heme oxygenase/4-helical cytokines | H: 4-helical cytokines (From Topology) | T: 4-helical cytokines | F: PF00726 | ECOD (1.6) |
B [auth L] | PF07654 | e1lk3L2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
B [auth L] | PF07686 | e1lk3L1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
E [auth M] | PF07654 | e1lk3M2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
E [auth M] | PF07686 | e1lk3M1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
F [auth I] | PF07654 | e1lk3I2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
F [auth I] | PF07686 | e1lk3I1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
C [auth H] | PF07654 | e1lk3H2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
C [auth H] | PF07686 | e1lk3H1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
D [auth B] | 1.20.1250.10 | Mainly Alpha | Up-down Bundle | Growth Hormone | Chain: A | CATH (4.3.0) |
A | 1.20.1250.10 | Mainly Alpha | Up-down Bundle | Growth Hormone | Chain: A | CATH (4.3.0) |
B [auth L] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
E [auth M] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
F [auth I] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
C [auth H] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
IMGT Antibody Annotation IMGT Database Homepage
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
---|---|---|---|---|---|---|---|---|
B [auth L], E [auth M] | 9D7 | L-KAPPA | Rattus norvegicus (Norway rat) | IGKV3S11*01, IGKJ2-3*01, IGKJ2-1*01, IGKJ2-2*01, IGKC*01 | V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA | IG | FAB-GAMMA-1_KAPPA | IMGT (202416-0) |
C [auth H], F [auth I] | 9D7 | VH-CH1 | Rattus norvegicus (Norway rat) | IGHV1-38*01, IGHJ3*01, IGHG1*01 | V-DOMAIN VH, C-DOMAIN CH1 | IG | FAB-GAMMA-1_KAPPA | IMGT (202416-0) |
SAbDab Antibody Annotation SAbDab Database Homepage
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
---|---|---|---|---|---|
B [auth L], E [auth M] | Light Chain | IGKV3 | Kappa | interleukin-10 | SAbDab (2024-04-26) |
C [auth H], F [auth I] | Heavy Chain | IGHV1 | - | interleukin-10 | SAbDab (2024-04-26) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A, D [auth B] | PF00726 | Interleukin 10 (IL10) | Interleukin 10 | - | Domain |
B [auth L], E [auth M] | PF07654 | Immunoglobulin C1-set domain (C1-set) | Immunoglobulin C1-set domain | - | Domain |
C [auth H], F [auth I] | PF07654 | Immunoglobulin C1-set domain (C1-set) | Immunoglobulin C1-set domain | - | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
A, D [auth B] | IPR020443 | Interleukin-10/19/20/22/24/26 family | Family |
A, D [auth B] | IPR020423 | Interleukin-10, conserved site | Conserved Site |
A, D [auth B] | IPR000098 | Interleukin-10 | Family |
A, D [auth B] | IPR009079 | Four-helical cytokine-like, core | Homologous Superfamily |
B [auth L], E [auth M] | IPR003597 | Immunoglobulin C1-set | Domain |
B [auth L], E [auth M] | IPR013783 | Immunoglobulin-like fold | Homologous Superfamily |
B [auth L], E [auth M] | IPR036179 | Immunoglobulin-like domain superfamily | Homologous Superfamily |
B [auth L], E [auth M] | IPR007110 | Immunoglobulin-like domain | Domain |
B [auth L], E [auth M] | IPR003006 | Immunoglobulin/major histocompatibility complex, conserved site | Conserved Site |
C [auth H], F [auth I] | IPR003597 | Immunoglobulin C1-set | Domain |
C [auth H], F [auth I] | IPR013783 | Immunoglobulin-like fold | Homologous Superfamily |
C [auth H], F [auth I] | IPR036179 | Immunoglobulin-like domain superfamily | Homologous Superfamily |
C [auth H], F [auth I] | IPR007110 | Immunoglobulin-like domain | Domain |