1L2Z

CD2BP2-GYF domain in complex with proline-rich CD2 tail segment peptide

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1l2za_	Alpha and beta proteins (a+b)	GYF/BRK domain-like	GYF domain	GYF domain	GYF domain from cd2bp2 protein	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	GYF domain-like	8032414	3001702	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	GYF	e1l2zA1	A: a+b two layers	X: GYF/BRK domain-like	H: GYF domain (From Topology)	T: GYF domain	F: GYF	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.1490.40	Alpha Beta	2-Layer Sandwich	Dna Ligase	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02213	GYF domain (GYF)	GYF domain	The GYF domain is named because of the presence of Gly-Tyr-Phe residues. The GYF domain is a proline-binding domain in CD2-binding protein Swiss:O95400.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CD2 ANTIGEN (CYTOPLASMIC TAIL)-BINDING PROTEIN 2	ribonucleoprotein complex binding protein-containing complex binding binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing spliceosomal tri-snRNP complex assembly protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing spliceosomal tri-snRNP complex assembly protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization spliceosomal snRNP assembly cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen fibrillar center organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen fibrillar center organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle U5 snRNP spliceosomal snRNP complex protein-containing complex nuclear protein-containing complex Sm-like protein family complex small nuclear ribonucleoprotein complex ribonucleoprotein complex nuclear speck nuclear body nucleoplasm
B	T-CELL SURFACE ANTIGEN CD2	molecular transducer activity signaling receptor activity protein binding binding signaling receptor binding protein tyrosine kinase binding kinase binding receptor tyrosine kinase binding enzyme binding protein kinase binding identical protein binding	cellular process apoptotic process cell death programmed cell death multicellular organismal process regulation of leukocyte differentiation regulation of cellular process cellular developmental process regulation of developmental process regulation of leukocyte activation cell development regulation of cell activation mononuclear cell differentiation regulation of cell differentiation cellular process apoptotic process cell death programmed cell death multicellular organismal process regulation of leukocyte differentiation regulation of cellular process cellular developmental process regulation of developmental process regulation of leukocyte activation cell development regulation of cell activation mononuclear cell differentiation regulation of cell differentiation lymphocyte activation lymphocyte differentiation regulation of cell development leukocyte activation regulation of T cell differentiation multicellular organism development T cell activation cell differentiation anatomical structure development T cell differentiation regulation of immune system process regulation of multicellular organismal process developmental process regulation of lymphocyte differentiation regulation of biological process regulation of multicellular organismal development hemopoiesis cell activation biological regulation regulation of T cell activation immune system process regulation of hemopoiesis leukocyte differentiation regulation of lymphocyte activation membrane organization cellular localization membrane raft polarization localization within membrane cellular component organization localization membrane raft localization membrane raft organization cellular component organization or biogenesis membrane raft distribution lymphocyte mediated immunity biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus leukocyte mediated cytotoxicity response to biotic stimulus immune effector process defense response to other organism response to stress natural killer cell mediated cytotoxicity innate immune response leukocyte mediated immunity response to external biotic stimulus natural killer cell mediated immunity cell killing positive regulation of interleukin-8 production cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process cytokine production organic substance biosynthetic process regulation of cytokine production positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process interleukin-8 production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression positive regulation of multicellular organismal process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process positive regulation of cellular biosynthetic process regulation of interleukin-8 production cellular response to stimulus cell surface receptor signaling pathway signaling signal transduction cell communication natural killer cell activation cell adhesion cell-cell adhesion heterotypic cell-cell adhesion regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production regulation of type II interferon production type II interferon production positive regulation of type II interferon production myeloid dendritic cell activation positive regulation of myeloid dendritic cell activation myeloid leukocyte activation positive regulation of cell activation regulation of myeloid dendritic cell activation positive regulation of leukocyte activation positive regulation of immune system process	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane cell-cell junction anchoring junction cell junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane cell-cell junction anchoring junction cell junction membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex Golgi apparatus cytoplasm endomembrane system extracellular region cytoplasmic side of plasma membrane cytoplasmic side of membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003169	GYF domain	Domain
A	IPR035445	GYF-like domain superfamily	Homologous Superfamily
A	IPR039905	CD2 antigen cytoplasmic tail-binding protein 2/Lin1	Family
B	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B	IPR015632	T-cell surface antigen CD2	Family
B	IPR013106	Immunoglobulin V-set domain	Domain
B	IPR008424	Immunoglobulin C2-set	Domain
B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O95400	diabetes mellitus osteosarcoma ovarian cancer
B	Pharos: P06729	rheumatoid arthritis nephrotic syndrome psoriasis Sjogren syndrome thrombotic disease atypical teratoid rhabdoid tumor gastric cancer gout invasive ductal breast carcinoma lung carcinoma Malignant neoplasm of breast pilocytic astrocytoma subependymal giant cell astrocytoma cancer gastric carcinoma rheumatoid arthritis nephrotic syndrome psoriasis Sjogren syndrome thrombotic disease atypical teratoid rhabdoid tumor gastric cancer gout invasive ductal breast carcinoma lung carcinoma Malignant neoplasm of breast pilocytic astrocytoma subependymal giant cell astrocytoma cancer gastric carcinoma hematologic disease large cell medulloblastoma lymphatic system disease sarcoidosis ulcerative colitis cutaneous lupus erythematosus glioblastoma interstitial cystitis lung cancer malignant glioma osteosarcoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.