1KT0

Structure of the Large FKBP-like Protein, FKBP51, Involved in Steroid Receptor Complexes

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1kt0a1	All alpha proteins	alpha-alpha superhelix	TPR-like	Tetratricopeptide repeat (TPR)	FKBP51, C-terminal domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1kt0a2	Alpha and beta proteins (a+b)	FKBP-like	FKBP-like	FKBP immunophilin/proline isomerase	FKBP51, N-terminal domains	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Tetratricopeptide repeat (TPR)	8030444	4001344	SCOP2 (2022-06-29)
A	SCOP2 Family	FKBP immunophilin/proline isomerase	8030445	4001062	SCOP2 (2022-06-29)
A	SCOP2 Family	FKBP immunophilin/proline isomerase	8030446	4001062	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	TPR-like	8042823	3001345	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Rotamase-like	8042824	3000622	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Rotamase-like	8042825	3000622	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	TPR_11_8	e1kt0A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_11_8	ECOD (1.6)
A	FKBP_C	e1kt0A2	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: FKBP_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.50.40	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)
A	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00515	Tetratricopeptide repeat (TPR_1)	Tetratricopeptide repeat	-	Repeat
A	PF00254	FKBP-type peptidyl-prolyl cis-trans isomerase (FKBP_C)	FKBP-type peptidyl-prolyl cis-trans isomerase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	51 KDA FK506-BINDING PROTEIN	isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity FK506 binding amide binding binding organic cyclic compound binding macrolide binding protein binding heat shock protein binding	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus chaperone-mediated protein folding	membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR046357	Peptidyl-prolyl cis-trans isomerase domain superfamily	Homologous Superfamily
A	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A	IPR001179	FKBP-type peptidyl-prolyl cis-trans isomerase domain	Domain
A	IPR001440	TPR_1	Unknown
A	IPR019734	Tetratricopeptide repeat	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q13451	rheumatoid arthritis endometriosis major depressive disorder Neurobehavioral Manifestations ovarian cancer glioblastoma pancreatic intraductal papillary-mucinous neoplasm hepatocellular carcinoma pilocytic astrocytoma astrocytic tumor lung lymphangioleiomyomatosis Sjogren syndrome bipolar disorder malignant glioma tuberous sclerosis rheumatoid arthritis endometriosis major depressive disorder Neurobehavioral Manifestations ovarian cancer glioblastoma pancreatic intraductal papillary-mucinous neoplasm hepatocellular carcinoma pilocytic astrocytoma astrocytic tumor lung lymphangioleiomyomatosis Sjogren syndrome bipolar disorder malignant glioma tuberous sclerosis colorectal cancer disappearing bone disease myopathy gastric cancer pancreatic ductal adenocarcinoma Hashimoto thyroiditis pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia hydrolethalus syndrome interstitial cystitis anxiety disorder lung adenocarcinoma atopic eczema malignant pancreatic neoplasm cystic fibrosis mood disorder Duchenne muscular dystrophy opiate dependence gastric carcinoma pancreatic intraductal papillary-mucinous carcinoma heart disease Pick disease hypothyroidism psoriasis large cell medulloblastoma renal cell carcinoma asthma lung cancer sinusitis atypical teratoid rhabdoid tumor lymphangioma malignant ependymoma tuberculosis colorectal adenoma medulloblastoma depressive disorder Emery-Dreifuss muscular dystrophy exocrine pancreatic carcinoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.