Annotations: 1KKE

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1kkeb2	All beta proteins	Virus attachment protein globular domain	Virus attachment protein globular domain	Reovirus attachment protein sigma 1 head domain	Reovirus attachment protein sigma 1 head domain	(Mammalian orthoreovirus 3 Dearing ) [TaxId: 10886 ],	SCOPe (2.08)
B	d1kkeb1	All beta proteins	Triple beta-spiral	Fibre shaft of virus attachment proteins	Reovirus attachment protein sigma 1	Reovirus attachment protein sigma 1	(Mammalian orthoreovirus 3 Dearing ) [TaxId: 10886 ],	SCOPe (2.08)
C	d1kkec2	All beta proteins	Virus attachment protein globular domain	Virus attachment protein globular domain	Reovirus attachment protein sigma 1 head domain	Reovirus attachment protein sigma 1 head domain	(Mammalian orthoreovirus 3 Dearing ) [TaxId: 10886 ],	SCOPe (2.08)
C	d1kkec1	All beta proteins	Triple beta-spiral	Fibre shaft of virus attachment proteins	Reovirus attachment protein sigma 1	Reovirus attachment protein sigma 1	(Mammalian orthoreovirus 3 Dearing ) [TaxId: 10886 ],	SCOPe (2.08)
A	d1kkea2	All beta proteins	Virus attachment protein globular domain	Virus attachment protein globular domain	Reovirus attachment protein sigma 1 head domain	Reovirus attachment protein sigma 1 head domain	(Mammalian orthoreovirus 3 Dearing ) [TaxId: 10886 ],	SCOPe (2.08)
A	d1kkea1	All beta proteins	Triple beta-spiral	Fibre shaft of virus attachment proteins	Reovirus attachment protein sigma 1	Reovirus attachment protein sigma 1	(Mammalian orthoreovirus 3 Dearing ) [TaxId: 10886 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Fibre shaft of virus attachment proteins	8038300	3001872	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Virus attachment protein globular domain	8038299	3001376	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Virus attachment protein globular domain	8038299	3001376	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Fibre shaft of virus attachment proteins	8038300	3001872	SCOP2B (2022-06-29)
A	SCOP2 Family	Reovirus attachment protein sigma 1 head domain	8025920	4003037	SCOP2 (2022-06-29)
A	SCOP2 Family	Reovirus attachment protein sigma 1	8025921	4003157	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Virus attachment protein globular domain	8038299	3001376	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Fibre shaft of virus attachment proteins	8038300	3001872	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Reo_sigma1_C	e1kkeB1	A: beta sandwiches	X: Domain in virus attachment proteins (From Topology)	H: Domain in virus attachment proteins (From Topology)	T: Domain in virus attachment proteins	F: Reo_sigma1_C	ECOD (1.6)
B		e1kkeB2	A: beta duplicates or obligate multimers	X: Triple beta-spiral (From Topology)	H: Triple beta-spiral (From Topology)	T: Triple beta-spiral	F:	ECOD (1.6)
C	Reo_sigma1_C	e1kkeC1	A: beta sandwiches	X: Domain in virus attachment proteins (From Topology)	H: Domain in virus attachment proteins (From Topology)	T: Domain in virus attachment proteins	F: Reo_sigma1_C	ECOD (1.6)
C		e1kkeC2	A: beta duplicates or obligate multimers	X: Triple beta-spiral (From Topology)	H: Triple beta-spiral (From Topology)	T: Triple beta-spiral	F:	ECOD (1.6)
A	Reo_sigma1_C	e1kkeA1	A: beta sandwiches	X: Domain in virus attachment proteins (From Topology)	H: Domain in virus attachment proteins (From Topology)	T: Domain in virus attachment proteins	F: Reo_sigma1_C	ECOD (1.6)
A		e1kkeA2	A: beta duplicates or obligate multimers	X: Triple beta-spiral (From Topology)	H: Triple beta-spiral (From Topology)	T: Triple beta-spiral	F:	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.10.25.20	Mainly Beta	Ribbon	Laminin	reovirus attachment protein sigma1	CATH (4.3.0)
B	2.60.90.20	Mainly Beta	Sandwich	Adenovirus Type 5 Fiber Protein (Receptor Binding Domain)	Virus attachment protein , globular domain	CATH (4.3.0)
C	2.10.25.20	Mainly Beta	Ribbon	Laminin	reovirus attachment protein sigma1	CATH (4.3.0)
C	2.60.90.20	Mainly Beta	Sandwich	Adenovirus Type 5 Fiber Protein (Receptor Binding Domain)	Virus attachment protein , globular domain	CATH (4.3.0)
A	2.10.25.20	Mainly Beta	Ribbon	Laminin	reovirus attachment protein sigma1	CATH (4.3.0)
A	2.60.90.20	Mainly Beta	Sandwich	Adenovirus Type 5 Fiber Protein (Receptor Binding Domain)	Virus attachment protein , globular domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF01664	Reovirus viral attachment protein sigma 1 (Reo_sigma1)	Reovirus viral attachment protein sigma 1	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	SIGMA 1 PROTEIN	-	biological process involved in interspecies interaction between organisms symbiont entry into host cell viral process symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host cell adhesion cellular process	viral capsid icosahedral viral capsid virion component viral outer capsid

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR009013	Attachment protein shaft domain superfamily	Homologous Superfamily
A, B, C	IPR008982	Adenovirus pIV-like, attachment domain	Homologous Superfamily
A, B, C	IPR002592	Viral attachment sigma 1, reoviral	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.