1K4U

Solution structure of the C-terminal SH3 domain of p67phox complexed with the C-terminal tail region of p47phox

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth S]	d1k4us_	All beta proteins	SH3-like barrel	SH3-domain	SH3-domain	p67phox	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth S]	SCOP2 Family	SH3-domain	8027671	4000369	SCOP2 (2022-06-29)
A [auth S]	SCOP2 Superfamily	SH3-domain	8040050	3000153	SCOP2 (2022-06-29)
B [auth P]	SCOP2B Superfamily	p47phox C-terminal polyProline region	8055767	3002303	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth S]	PF00018	e1k4uS1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF00018	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth S]	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth S]	PF00018	SH3 domain (SH3_1)	SH3 domain	SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.	Domain
B [auth P]	PF08944	NADPH oxidase subunit p47Phox, C terminal domain (p47_phox_C)	NADPH oxidase subunit p47Phox, C terminal domain	-	Disordered

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth S]	PHAGOCYTE NADPH OXIDASE SUBUNIT P67PHOX	small GTPase binding protein binding binding enzyme binding GTPase binding superoxide-generating NADPH oxidase activator activity enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity oxidoreductase activity superoxide-generating NAD(P)H oxidase activity oxidoreductase activity, acting on NAD(P)H catalytic activity small GTPase binding protein binding binding enzyme binding GTPase binding superoxide-generating NADPH oxidase activator activity enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity oxidoreductase activity superoxide-generating NAD(P)H oxidase activity oxidoreductase activity, acting on NAD(P)H catalytic activity oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor electron transfer activity	superoxide metabolic process superoxide anion generation cellular metabolic process reactive oxygen species metabolic process metabolic process cellular process localization import into cell transport phagocytosis endocytosis establishment of localization vesicle-mediated transport response to stimulus superoxide metabolic process superoxide anion generation cellular metabolic process reactive oxygen species metabolic process metabolic process cellular process localization import into cell transport phagocytosis endocytosis establishment of localization vesicle-mediated transport response to stimulus defense response response to stress cellular defense response respiratory burst biological process involved in interspecies interaction between organisms immune response response to other organism defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism innate immune response response to external biotic stimulus	membrane cellular anatomical entity membrane-bounded organelle phagolysosome intracellular anatomical structure lytic vacuole intracellular vesicle vacuole phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle secondary lysosome membrane cellular anatomical entity membrane-bounded organelle phagolysosome intracellular anatomical structure lytic vacuole intracellular vesicle vacuole phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle secondary lysosome cytoplasm vesicle endocytic vesicle lysosome cytosol cell periphery plasma membrane protein-containing complex catalytic complex plasma membrane protein complex NADPH oxidase complex membrane protein complex oxidoreductase complex acrosomal vesicle endomembrane system secretory granule secretory vesicle
B [auth P]	PHAGOCYTE NADPH OXIDASE SUBUNIT P47PHOX	binding phospholipid binding lipid binding phosphatidylinositol binding electron transfer activity SH3 domain binding protein binding protein domain specific binding ion binding anion binding phosphatidylinositol-3,4-bisphosphate binding small molecule binding superoxide-generating NADPH oxidase activator activity enzyme regulator activity binding phospholipid binding lipid binding phosphatidylinositol binding electron transfer activity SH3 domain binding protein binding protein domain specific binding ion binding anion binding phosphatidylinositol-3,4-bisphosphate binding small molecule binding superoxide-generating NADPH oxidase activator activity enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity oxidoreductase activity superoxide-generating NAD(P)H oxidase activity oxidoreductase activity, acting on NAD(P)H catalytic activity oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	regulation of immune effector process multicellular organismal process regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus response to biotic stimulus regulation of respiratory burst involved in inflammatory response response to stress regulation of response to stress innate immune response regulation of immune system process regulation of multicellular organismal process regulation of immune effector process multicellular organismal process regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus response to biotic stimulus regulation of respiratory burst involved in inflammatory response response to stress regulation of response to stress innate immune response regulation of immune system process regulation of multicellular organismal process response to external biotic stimulus regulation of respiratory burst production of molecular mediator involved in inflammatory response regulation of biological process respiratory burst involved in defense response defense response immune response response to other organism regulation of innate immune response biological regulation defense response to symbiont response to external stimulus regulation of inflammatory response immune effector process respiratory burst regulation of response to stimulus immune system process defense response to other organism respiratory burst involved in inflammatory response regulation of immune response metabolic process inflammatory response regulation of metabolic process superoxide metabolic process superoxide anion generation cellular metabolic process reactive oxygen species metabolic process cellular process cellular response to stimulus response to organic substance homeostatic process response to monosaccharide response to carbohydrate carbohydrate homeostasis cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus cellular response to organic substance response to oxygen-containing compound cellular response to glucose stimulus intracellular glucose homeostasis cellular response to oxygen-containing compound response to hexose cellular response to carbohydrate stimulus cellular response to chemical stimulus cellular homeostasis chemical homeostasis response to glucose response to chemical glucose homeostasis positive regulation of cell communication regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of signaling positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of cell communication phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signaling protein localization establishment of protein localization cellular localization establishment of protein localization to membrane protein targeting localization within membrane protein localization to membrane establishment of localization protein targeting to membrane localization cellular macromolecule localization macromolecule localization positive regulation of JNK cascade JNK cascade positive regulation of MAPK cascade regulation of JNK cascade regulation of MAPK cascade MAPK cascade cellular response to oxidative stress cellular response to chemical stress response to reactive oxygen species cellular response to reactive oxygen species response to oxidative stress cellular response to stress positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process protein modification process phosphorus metabolic process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process positive regulation of epidermal growth factor-activated receptor activity phosphorylation positive regulation of signaling receptor activity regulation of protein metabolic process primary metabolic process regulation of cellular metabolic process regulation of molecular function positive regulation of kinase activity regulation of protein tyrosine kinase activity regulation of kinase activity macromolecule modification regulation of phosphorus metabolic process macromolecule metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process regulation of signaling receptor activity regulation of epidermal growth factor-activated receptor activity positive regulation of cellular metabolic process peptidyl-tyrosine modification positive regulation of molecular function positive regulation of protein modification process positive regulation of peptidyl-tyrosine phosphorylation organic substance metabolic process protein metabolic process positive regulation of protein kinase activity organonitrogen compound metabolic process positive regulation of transferase activity positive regulation of protein tyrosine kinase activity regulation of peptidyl-tyrosine phosphorylation positive regulation of catalytic activity regulation of macromolecule metabolic process regulation of protein kinase activity regulation of phosphorylation peptidyl-tyrosine phosphorylation cellular response to testosterone stimulus response to ketone response to lipid cellular response to organic cyclic compound response to testosterone cellular response to lipid cellular response to ketone response to organic cyclic compound positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process p38MAPK cascade positive regulation of p38MAPK cascade regulation of p38MAPK cascade cellular defense response cellular response to inorganic substance cellular response to metal ion response to cadmium ion response to inorganic substance response to metal ion cellular response to cadmium ion reactive oxygen species biosynthetic process	membrane cellular anatomical entity membrane-bounded organelle phagolysosome intracellular anatomical structure lytic vacuole intracellular vesicle vacuole phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle secondary lysosome membrane cellular anatomical entity membrane-bounded organelle phagolysosome intracellular anatomical structure lytic vacuole intracellular vesicle vacuole phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle secondary lysosome cytoplasm vesicle endocytic vesicle lysosome cytosol cell periphery plasma membrane protein-containing complex catalytic complex plasma membrane protein complex NADPH oxidase complex membrane protein complex oxidoreductase complex somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection cell body neuronal cell body cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth S]	IPR034889	Neutrophil cytosol factor 2, SH3 domain	Domain
A [auth S]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A [auth S]	IPR000270	PB1 domain	Domain
A [auth S]	IPR001452	SH3 domain	Domain
A [auth S]	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A [auth S]	IPR034885	Neutrophil cytosol factor 2, PB1 domain	Domain
A [auth S]	IPR035546	Neutrophil cytosol factor 2, SH3 domain 1	Domain
A [auth S]	IPR019734	Tetratricopeptide repeat	Repeat
B [auth P]	IPR034909	Neutrophil cytosol factor 1, PX domain	Domain
B [auth P]	IPR032136	Neutrophil cytosol factor 1, PBR/AIR	Domain
B [auth P]	IPR001683	Phox homology	Domain
B [auth P]	IPR036028	SH3-like domain superfamily	Homologous Superfamily
B [auth P]	IPR035757	Neutrophil cytosol factor 1, second SH3 domain	Domain
B [auth P]	IPR015039	Neutrophil cytosol factor 1, C-terminal	Domain
B [auth P]	IPR035756	Neutrophil cytosol factor 1, first SH3 domain	Domain
B [auth P]	IPR036871	PX domain superfamily	Homologous Superfamily
B [auth P]	IPR001452	SH3 domain	Domain
B [auth P]	IPR001655	Neutrophil cytosol factor 1	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth S]	Pharos: P19878	chronic granulomatous disease granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type 2 rheumatoid arthritis systemic lupus erythematosus osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia breast cancer cystic fibrosis invasive ductal breast carcinoma lung carcinoma malignant glioma myositis ovarian cancer phagocyte bactericidal dysfunction systemic sclerosis chronic granulomatous disease granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type 2 rheumatoid arthritis systemic lupus erythematosus osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia breast cancer cystic fibrosis invasive ductal breast carcinoma lung carcinoma malignant glioma myositis ovarian cancer phagocyte bactericidal dysfunction systemic sclerosis celiac disease diabetes mellitus IgA glomerulonephritis lung adenocarcinoma lupus erythematosus malignant pancreatic neoplasm non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma ulcerative colitis glioblastoma interstitial cystitis lung cancer malignant ependymoma MALT lymphoma
B [auth P]	Pharos: P14598	chronic granulomatous disease granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type 1 abdominal aortic aneurysm rheumatoid arthritis brain aneurysm hypertensive disorder Sjogren syndrome diabetes mellitus Diabetes Mellitus, Experimental chronic kidney disease phagocyte bactericidal dysfunction systemic lupus erythematosus Williams syndrome atrial fibrillation

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.