1JPY

Crystal structure of IL-17F

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1jpyb_	Small proteins	Cystine-knot cytokines	Cystine-knot cytokines	Interleukin 17F, IL-17F	Interleukin 17F, IL-17F	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth X]	d1jpyx_	Small proteins	Cystine-knot cytokines	Cystine-knot cytokines	Interleukin 17F, IL-17F	Interleukin 17F, IL-17F	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1jpya_	Small proteins	Cystine-knot cytokines	Cystine-knot cytokines	Interleukin 17F, IL-17F	Interleukin 17F, IL-17F	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth Y]	d1jpyy_	Small proteins	Cystine-knot cytokines	Cystine-knot cytokines	Interleukin 17F, IL-17F	Interleukin 17F, IL-17F	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Cystine-knot cytokines	8037216	3000846	SCOP2B (2022-06-29)
C [auth X]	SCOP2B Superfamily	Cystine-knot cytokines	8037216	3000846	SCOP2B (2022-06-29)
A	SCOP2 Family	Interleukin 17F IL-17F	8024837	4003639	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Cystine-knot cytokines	8037216	3000846	SCOP2 (2022-06-29)
D [auth Y]	SCOP2B Superfamily	Cystine-knot cytokines	8037216	3000846	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	IL17	e1jpyB1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: IL17	ECOD (1.6)
C [auth X]	IL17	e1jpyX1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: IL17	ECOD (1.6)
A	IL17	e1jpyA1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: IL17	ECOD (1.6)
D [auth Y]	IL17	e1jpyY1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: IL17	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	CATH (4.3.0)
C [auth X]	2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	CATH (4.3.0)
A	2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	CATH (4.3.0)
D [auth Y]	2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C [auth X], D [auth Y]	PF06083	Interleukin-17 (IL17)	Interleukin-17	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C [auth X], D [auth Y]	interleukin 17F	protein heterodimerization activity protein binding binding protein dimerization activity cytokine binding identical protein binding protein homodimerization activity molecular function activator activity signaling receptor binding molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity protein heterodimerization activity protein binding binding protein dimerization activity cytokine binding identical protein binding protein homodimerization activity molecular function activator activity signaling receptor binding molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity cytokine receptor binding	developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development granulocyte macrophage colony-stimulating factor production regulation of cellular process cellular biosynthetic process organonitrogen compound biosynthetic process developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development granulocyte macrophage colony-stimulating factor production regulation of cellular process cellular biosynthetic process organonitrogen compound biosynthetic process regulation of primary metabolic process organic substance metabolic process cytokine production organic substance biosynthetic process regulation of cytokine production regulation of multicellular organismal process protein metabolic process regulation of biosynthetic process regulation of granulocyte macrophage colony-stimulating factor production regulation of biological process organonitrogen compound metabolic process regulation of protein metabolic process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process regulation of interleukin-2 production interleukin-2 production interleukin-8 production regulation of interleukin-8 production response to stimulus immune response immune system process adaptive immune response cellular response to stimulus cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway signaling cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of signal transduction regulation of transforming growth factor beta receptor signaling pathway cell communication cellular response to endogenous stimulus signal transduction enzyme-linked receptor protein signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus response to transforming growth factor beta regulation of response to stimulus transforming growth factor beta receptor signaling pathway regulation of cell communication response to growth factor transforming growth factor beta receptor superfamily signaling pathway interleukin-6 production positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of interleukin-6 production regulation of interleukin-6 production positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of cytokine production positive regulation of cellular biosynthetic process biological process involved in interspecies interaction between organisms response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to other organism response to stress innate immune response response to external biotic stimulus chemokine (C-X-C motif) ligand 1 production regulation of chemokine production chemokine production positive regulation of chemokine production regulation of chemokine (C-X-C motif) ligand 1 production positive regulation of chemokine (C-X-C motif) ligand 1 production response to organic substance cellular response to interleukin-17 response to interleukin-17 response to cytokine cytokine-mediated signaling pathway cellular response to chemical stimulus interleukin-17-mediated signaling pathway response to chemical cellular response to cytokine stimulus cellular response to organic substance regulation of humoral immune response regulation of immune effector process positive regulation of response to biotic stimulus antimicrobial humoral immune response mediated by antimicrobial peptide positive regulation of immune response regulation of immune system process positive regulation of immune system process immune effector process positive regulation of defense response positive regulation of production of molecular mediator of immune response regulation of immune response regulation of production of molecular mediator of immune response regulation of defense response humoral immune response regulation of response to biotic stimulus regulation of response to external stimulus antimicrobial humoral response positive regulation of response to stimulus positive regulation of antimicrobial peptide production positive regulation of humoral immune response positive regulation of response to external stimulus antimicrobial peptide production regulation of response to stress positive regulation of immune effector process production of molecular mediator of immune response regulation of antimicrobial humoral response positive regulation of antimicrobial humoral response regulation of antimicrobial peptide production lymphotoxin A production tumor necrosis factor superfamily cytokine production positive regulation of lymphotoxin A production regulation of tumor necrosis factor superfamily cytokine production positive regulation of protein metabolic process positive regulation of tumor necrosis factor superfamily cytokine production regulation of lymphotoxin A production defense response to Gram-negative bacterium defense response to bacterium response to bacterium regulation of cytokine production involved in inflammatory response production of molecular mediator involved in inflammatory response cytokine production involved in inflammatory response positive regulation of cytokine production involved in inflammatory response inflammatory response regulation of developmental process negative regulation of biological process angiogenesis regulation of vasculature development tube morphogenesis regulation of anatomical structure morphogenesis blood vessel development regulation of multicellular organismal development blood vessel morphogenesis tube development negative regulation of blood vessel morphogenesis negative regulation of developmental process negative regulation of angiogenesis vasculature development circulatory system development negative regulation of vasculature development anatomical structure morphogenesis regulation of angiogenesis anatomical structure formation involved in morphogenesis negative regulation of multicellular organismal process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA biosynthetic process defense response to Gram-positive bacterium	extracellular region cellular anatomical entity extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C [auth X], D [auth Y]	IPR029034	Cystine-knot cytokine	Homologous Superfamily
A, B, C [auth X], D [auth Y]	IPR010345	Interleukin-17 family	Family
A, B, C [auth X], D [auth Y]	IPR020440	Interleukin-17, chordata	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C [auth X], D [auth Y]	Pharos: Q96PD4	chronic mucocutaneous candidiasis candidiasis, familial, 6 psoriasis arthritic joint disease inflammatory bowel disease candidiasis Erythrodermic psoriasis nail disease exocrine pancreatic carcinoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.