1JOF

Neurospora crassa 3-carboxy-cis,cis-mucoante lactonizing enzyme

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Structure Motif: Primary M-CSA Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1jofa_	All beta proteins	7-bladed beta-propeller	3-carboxy-cis,cis-mucoante lactonizing enzyme	3-carboxy-cis,cis-mucoante lactonizing enzyme	3-carboxy-cis,cis-mucoante lactonizing enzyme	(Neurospora crassa ) [TaxId: 5141 ],	SCOPe (2.08)
B	d1jofb_	All beta proteins	7-bladed beta-propeller	3-carboxy-cis,cis-mucoante lactonizing enzyme	3-carboxy-cis,cis-mucoante lactonizing enzyme	3-carboxy-cis,cis-mucoante lactonizing enzyme	(Neurospora crassa ) [TaxId: 5141 ],	SCOPe (2.08)
C	d1jofc_	All beta proteins	7-bladed beta-propeller	3-carboxy-cis,cis-mucoante lactonizing enzyme	3-carboxy-cis,cis-mucoante lactonizing enzyme	3-carboxy-cis,cis-mucoante lactonizing enzyme	(Neurospora crassa ) [TaxId: 5141 ],	SCOPe (2.08)
D	d1jofd_	All beta proteins	7-bladed beta-propeller	3-carboxy-cis,cis-mucoante lactonizing enzyme	3-carboxy-cis,cis-mucoante lactonizing enzyme	3-carboxy-cis,cis-mucoante lactonizing enzyme	(Neurospora crassa ) [TaxId: 5141 ],	SCOPe (2.08)
E	d1jofe_	All beta proteins	7-bladed beta-propeller	3-carboxy-cis,cis-mucoante lactonizing enzyme	3-carboxy-cis,cis-mucoante lactonizing enzyme	3-carboxy-cis,cis-mucoante lactonizing enzyme	(Neurospora crassa ) [TaxId: 5141 ],	SCOPe (2.08)
F	d1joff_	All beta proteins	7-bladed beta-propeller	3-carboxy-cis,cis-mucoante lactonizing enzyme	3-carboxy-cis,cis-mucoante lactonizing enzyme	3-carboxy-cis,cis-mucoante lactonizing enzyme	(Neurospora crassa ) [TaxId: 5141 ],	SCOPe (2.08)
G	d1jofg_	All beta proteins	7-bladed beta-propeller	3-carboxy-cis,cis-mucoante lactonizing enzyme	3-carboxy-cis,cis-mucoante lactonizing enzyme	3-carboxy-cis,cis-mucoante lactonizing enzyme	(Neurospora crassa ) [TaxId: 5141 ],	SCOPe (2.08)
H	d1jofh_	All beta proteins	7-bladed beta-propeller	3-carboxy-cis,cis-mucoante lactonizing enzyme	3-carboxy-cis,cis-mucoante lactonizing enzyme	3-carboxy-cis,cis-mucoante lactonizing enzyme	(Neurospora crassa ) [TaxId: 5141 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	3-carboxy-cis cis-mucoante lactonizing enzyme	8027585	4002130	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	3-carboxy-cis cis-mucoante lactonizing enzyme	8039964	3000857	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	3-carboxy-cis cis-mucoante lactonizing enzyme	8039964	3000857	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	3-carboxy-cis cis-mucoante lactonizing enzyme	8039964	3000857	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	3-carboxy-cis cis-mucoante lactonizing enzyme	8039964	3000857	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	3-carboxy-cis cis-mucoante lactonizing enzyme	8039964	3000857	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	3-carboxy-cis cis-mucoante lactonizing enzyme	8039964	3000857	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	3-carboxy-cis cis-mucoante lactonizing enzyme	8039964	3000857	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	3-carboxy-cis cis-mucoante lactonizing enzyme	8039964	3000857	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Lactonase	e1jofA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Lactonase	ECOD (1.6)
B	Lactonase	e1jofB1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Lactonase	ECOD (1.6)
C	Lactonase	e1jofC1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Lactonase	ECOD (1.6)
D	Lactonase	e1jofD1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Lactonase	ECOD (1.6)
E	Lactonase	e1jofE1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Lactonase	ECOD (1.6)
F	Lactonase	e1jofF1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Lactonase	ECOD (1.6)
G	Lactonase	e1jofG1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Lactonase	ECOD (1.6)
H	Lactonase	e1jofH1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Lactonase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
B	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
C	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
D	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
E	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
F	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
G	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
H	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF10282	Lactonase, 7-bladed beta-propeller (Lactonase)	Lactonase, 7-bladed beta-propeller	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	CARBOXY-CIS,CIS-MUCONATE CYCLASE	intramolecular lyase activity isomerase activity cyclase activity carboxy-cis,cis-muconate cyclase activity catalytic activity hydrolase activity, acting on ester bonds 6-phosphogluconolactonase activity carboxylic ester hydrolase activity hydrolase activity	catabolic process beta-ketoadipate pathway metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR019405	Lactonase, 7-bladed beta propeller	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	carboxy-cis,cis-muconate cyclase M-CSA #542	Eukaryote 3-carboxy-cis,cis-muconate lactonizing enzyme is an eukaryote muconate lactonizing enzyme(MLE), converting cis,cis-muconates to muconlactones. It is in the class of CyclicMLE among the three classes of muconate lactonizing enzymes. The other 2 classes are bacterial CyclicMLE and bacterial MLE. The three classes of MLE are structurally very different but catalyse an analogous reaction, i.e. convergent functional evolution occurred.	Defined by 4 residues: HIS:A-148ARG:A-196GLU:A-212ARG:A-274 \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 5.5.1.5 (PDB Primary Data) Search M-CSA Motif + EC 5.5.1.5

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.