Annotations: 1JHN

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1jhna4	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Calnexin/calreticulin	Calnexin	dog (Canis lupus familiaris ) [TaxId: 9615 ],	SCOPe (2.08)
A	d1jhna3	All beta proteins	P-domain of calnexin/calreticulin	P-domain of calnexin/calreticulin	P-domain of calnexin/calreticulin	Calnexin	dog (Canis lupus familiaris ) [TaxId: 9615 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Calnexin/calreticulin	8026141	4003048	SCOP2 (2022-06-29)
A	SCOP2 Family	P-domain of calnexin/calreticulin	8024644	4003308	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Concanavalin A-like lectins/glucanases	8038520	3000120	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	P-domain of calnexin/calreticulin	8037023	3000577	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Calreticulin_1st	e1jhnA1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Calreticulin_1st	ECOD (1.6)
A	Calreticulin_2nd	e1jhnA2	A: few secondary structure elements	X: P-domain of calnexin/calreticulin (From Topology)	H: P-domain of calnexin/calreticulin (From Topology)	T: P-domain of calnexin/calreticulin	F: Calreticulin_2nd	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
A	2.10.250.10	Mainly Beta	Ribbon	Calnexin lumenal domain, non-globular proline-rich hairpin domain	Calreticulin/calnexin, P domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00262	Calreticulin family (Calreticulin)	Calreticulin family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	calnexin	binding carbohydrate binding cation binding ion binding calcium ion binding metal ion binding small molecule binding unfolded protein binding protein binding	synaptic vesicle endocytosis import into cell cellular localization transport synaptic vesicle cycle establishment of localization vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse synaptic vesicle recycling localization establishment of localization in cell cellular process endocytosis synaptic vesicle endocytosis import into cell cellular localization transport synaptic vesicle cycle establishment of localization vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse synaptic vesicle recycling localization establishment of localization in cell cellular process endocytosis organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process protein metabolic process macromolecule metabolic process clathrin-dependent endocytosis receptor-mediated endocytosis	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure mitochondrion membrane cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle organelle envelope mitochondrial envelope organelle cytoplasm organelle membrane presynapse membrane-bounded organelle mitochondrial membrane intracellular anatomical structure mitochondrion membrane cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle organelle envelope mitochondrial envelope organelle cytoplasm organelle membrane presynapse synapse cell junction pigment granule intracellular vesicle chitosome melanosome cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane melanosome membrane vesicle pigment granule membrane endoplasmic reticulum endomembrane system organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001580	Calreticulin/calnexin	Family
A	IPR009033	Calreticulin/calnexin, P domain superfamily	Homologous Superfamily
A	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A	IPR018124	Calreticulin/calnexin, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.