Annotations: 1JGG

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C [auth A]	d1jgga_	All alpha proteins	DNA/RNA-binding 3-helical bundle	Homeodomain-like	Homeodomain	Even-skipped homeodomain	fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
D [auth B]	d1jggb_	All alpha proteins	DNA/RNA-binding 3-helical bundle	Homeodomain-like	Homeodomain	Even-skipped homeodomain	fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth A]	SCOP2 Family	Homeodomain	8002376	4000291	SCOP2 (2022-06-29)
C [auth A]	SCOP2 Superfamily	Homeodomain-like	8057603	3000001	SCOP2 (2022-06-29)
D [auth B]	SCOP2B Superfamily	Homeodomain-like	8057603	3000001	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth A]	Homeobox	e1jggA1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: Homeobox	ECOD (1.6)
D [auth B]	Homeobox	e1jggB1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: Homeobox	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth A]	1.10.10.60	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Homeodomain-like	CATH (4.3.0)
D [auth B]	1.10.10.60	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Homeodomain-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth A], D [auth B]	PF00046	Homeodomain (Homeodomain)	Homeodomain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C]	5'-D(PTPAPAPTPTPGPAPAPTPT)-3'	-	-	-
B [auth D]	5'-D(PAPAPTPTPCPAPAPTPTPA)-3'	-	-	-
C [auth A], D [auth B]	Segmentation Protein Even-Skipped	DNA binding binding organic cyclic compound binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity sequence-specific DNA binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding DNA binding binding organic cyclic compound binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity sequence-specific DNA binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding	developmental process multicellular organismal process embryonic morphogenesis embryo development gastrulation germ-band extension multicellular organism development anatomical structure morphogenesis anatomical structure development gastrulation with mouth forming first gastrulation involving germ band extension regulation of neuron projection development axonogenesis regulation of cellular component organization developmental process multicellular organismal process embryonic morphogenesis embryo development gastrulation germ-band extension multicellular organism development anatomical structure morphogenesis anatomical structure development gastrulation with mouth forming first gastrulation involving germ band extension regulation of neuron projection development axonogenesis regulation of cellular component organization regulation of cellular process cellular developmental process regulation of developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis regulation of axonogenesis cell differentiation cellular component organization or biogenesis regulation of anatomical structure morphogenesis system development regulation of biological process plasma membrane bounded cell projection organization regulation of cell projection organization biological regulation nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons neuron development cellular process regulation of plasma membrane bounded cell projection organization blastoderm segmentation embryonic pattern specification anterior/posterior pattern specification segmentation pattern specification process regionalization periodic partitioning periodic partitioning by pair rule gene cellular biosynthetic process RNA metabolic process regulation of primary metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II regulation of biosynthetic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process motor neuron axon guidance axon guidance neuron projection guidance heart development animal organ development adult heart development circulatory system development trunk segmentation negative regulation of biological process negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process head development head segmentation posterior head segmentation negative regulation of stem cell differentiation negative regulation of cell fate specification regulation of cardioblast cell fate specification regulation of cell differentiation cardioblast cell fate commitment negative regulation of cell fate commitment negative regulation of cardioblast cell fate specification regulation of cardioblast differentiation negative regulation of cardiac cell fate specification cardiac cell fate specification regulation of stem cell differentiation negative regulation of cell differentiation regulation of multicellular organismal process cardiac cell fate commitment negative regulation of cardiocyte differentiation negative regulation of cardioblast differentiation negative regulation of developmental process regulation of cell fate commitment cell fate specification cardiocyte differentiation cardioblast differentiation stem cell differentiation regulation of cell fate specification regulation of cardiocyte differentiation negative regulation of multicellular organismal process cardioblast cell fate specification regulation of cardiac cell fate specification cell fate commitment positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process anatomical structure formation involved in morphogenesis cephalic furrow formation heart morphogenesis animal organ morphogenesis regulation of syncytium formation by plasma membrane fusion cell-cell fusion muscle cell differentiation myotube differentiation muscle structure development syncytium formation myoblast fusion regulation of myoblast fusion syncytium formation by plasma membrane fusion striated muscle cell differentiation	membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth A], D [auth B]	IPR001356	Homeobox domain	Domain
C [auth A], D [auth B]	IPR009057	Homeobox-like domain superfamily	Homologous Superfamily
C [auth A], D [auth B]	IPR017970	Homeobox, conserved site	Conserved Site
C [auth A], D [auth B]	IPR020479	Homeobox domain, metazoa	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.