1J4N

Crystal Structure of the AQP1 water channel

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1j4na_	Membrane and cell surface proteins and peptides	Aquaporin-like	Aquaporin-like	Aquaporin-like	Aquaporin-1	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Aquaporin-like	8027429	4003025	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Aquaporin-like	8039808	3000508	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MIP	e1j4nA1	A: alpha complex topology	X: Aquaporin-like (From Topology)	H: Aquaporin-like (From Topology)	T: Aquaporin-like	F: MIP	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1080.10	Mainly Alpha	Up-down Bundle	Glycerol uptake facilitator protein	Glycerol uptake facilitator protein.	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00230	Major intrinsic protein (MIP)	Major intrinsic protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	AQUAPORIN 1	passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity transporter activity transmembrane transporter activity ammonium transmembrane transporter activity water transmembrane transporter activity nitric oxide transmembrane transporter activity identical protein binding protein binding binding carbon dioxide transmembrane transporter activity monoatomic cation transmembrane transporter activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity transporter activity transmembrane transporter activity ammonium transmembrane transporter activity water transmembrane transporter activity nitric oxide transmembrane transporter activity identical protein binding protein binding binding carbon dioxide transmembrane transporter activity monoatomic cation transmembrane transporter activity potassium ion transmembrane transporter activity monoatomic ion channel activity potassium channel activity monoatomic cation channel activity monoatomic ion transmembrane transporter activity metal ion transmembrane transporter activity intracellularly ligand-gated monoatomic ion channel activity gated channel activity intracellularly cyclic nucleotide-activated monoatomic cation channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity ligand-gated monoatomic cation channel activity cyclic nucleotide-activated monoatomic ion channel activity intracellularly cGMP-activated cation channel activity water channel activity organic hydroxy compound transmembrane transporter activity glycerol transmembrane transporter activity polyol transmembrane transporter activity carbohydrate transmembrane transporter activity	multicellular organismal process regulation of body fluid levels secretion by tissue secretion transport biological regulation cerebrospinal fluid secretion establishment of localization localization body fluid secretion regulation of biological quality renal system process system process homeostatic process multicellular organismal process regulation of body fluid levels secretion by tissue secretion transport biological regulation cerebrospinal fluid secretion establishment of localization localization body fluid secretion regulation of biological quality renal system process system process homeostatic process fluid transport water transport renal water transport multicellular organismal-level homeostasis chemical homeostasis multicellular organismal-level water homeostasis multicellular organismal-level chemical homeostasis renal water homeostasis response to decreased oxygen levels cellular response to stimulus response to stimulus cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus cellular response to stress response to hypoxia response to stress response to chemical response to oxygen levels response to abiotic stimulus cellular process developmental process head development lateral ventricle development forebrain development animal organ development brain development nervous system development multicellular organism development central nervous system development ventricular system development anatomical structure development telencephalon development system development response to organic substance response to lipid response to oxygen-containing compound cellular response to oxygen-containing compound response to retinoic acid cellular response to retinoic acid cellular response to lipid cellular response to organic substance response to ketone cellular response to endogenous stimulus response to hormone response to steroid hormone cellular response to ketone cellular response to steroid hormone stimulus response to organic cyclic compound cellular response to hormone stimulus response to endogenous stimulus cellular response to dexamethasone stimulus response to glucocorticoid cellular response to organic cyclic compound cellular response to glucocorticoid stimulus cellular response to corticosteroid stimulus response to corticosteroid response to dexamethasone response to osmotic stress cellular response to chemical stress cellular response to osmotic stress cellular response to environmental stimulus hyperosmotic response cellular hyperosmotic response cellular response to abiotic stimulus transepithelial water transport epithelial fluid transport transepithelial transport one-carbon compound transport gas transport organic substance transport carbon dioxide transport transmembrane transport carbon dioxide transmembrane transport anatomical structure morphogenesis odontogenesis animal organ morphogenesis pancreatic juice secretion digestive system process digestion cellular response to inorganic substance cellular response to metal ion response to mercury ion response to inorganic substance response to metal ion cellular response to mercury ion biological process involved in interspecies interaction between organisms response to other organism defense response response to external stimulus defense response to Gram-negative bacterium response to biotic stimulus defense response to bacterium defense response to other organism response to bacterium response to external biotic stimulus regulation of localization regulation of system process positive regulation of biological process saliva secretion positive regulation of secretion regulation of saliva secretion positive regulation of digestive system process regulation of multicellular organismal process regulation of biological process regulation of transport regulation of digestive system process regulation of secretion positive regulation of transport positive regulation of multicellular organismal process positive regulation of saliva secretion cellular response to salt stress response to salt stress cellular response to nitrogen compound response to nitrogen compound cellular response to nitric oxide response to nitric oxide cellular response to reactive nitrogen species nitrogen compound transport ammonium transmembrane transport inorganic ion transmembrane transport inorganic cation transmembrane transport cellular homeostasis polyol transmembrane transport carbohydrate transport organic hydroxy compound transport glycerol transmembrane transport carbohydrate transmembrane transport cellular component organization establishment or maintenance of actin cytoskeleton polarity organelle organization establishment or maintenance of cytoskeleton polarity actin cytoskeleton organization actin filament-based process cellular component organization or biogenesis establishment or maintenance of cell polarity cytoskeleton organization regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death fibroblast proliferation cell population proliferation positive regulation of cell population proliferation regulation of fibroblast proliferation regulation of cell population proliferation positive regulation of fibroblast proliferation positive regulation of cellular process signaling cGMP-mediated signaling intracellular signal transduction cell communication intracellular signaling cassette signal transduction regulation of cellular component size cell volume homeostasis regulation of cell size regulation of anatomical structure size response to organonitrogen compound response to organophosphorus response to purine-containing compound response to cAMP cellular response to organonitrogen compound cellular response to cAMP intracellular water homeostasis intracellular chemical homeostasis response to copper ion cellular response to copper ion cellular response to oxidative stress cellular response to hydrogen peroxide response to reactive oxygen species response to hydrogen peroxide response to oxidative stress cellular response to reactive oxygen species response to mechanical stimulus cellular response to mechanical stimulus cellular response to external stimulus nitric oxide transport response to light stimulus cellular response to radiation response to UV cellular response to light stimulus response to radiation cellular response to UV regulation of developmental process angiogenesis regulation of vasculature development positive regulation of developmental process tube morphogenesis regulation of anatomical structure morphogenesis blood vessel development regulation of multicellular organismal development blood vessel morphogenesis tube development positive regulation of angiogenesis vasculature development circulatory system development positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis	membrane-bounded organelle intracellular anatomical structure dense core granule membrane intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle membrane-bounded organelle intracellular anatomical structure dense core granule membrane intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle secretory granule dense core granule membrane secretory vesicle cytoplasm vesicle organelle membrane secretory granule membrane ankyrin-1 complex protein-containing complex membrane protein complex apical part of cell nuclear membrane nucleus organelle envelope nuclear envelope extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cell periphery sarcolemma plasma membrane basal part of cell basal plasma membrane plasma membrane region basolateral plasma membrane cluster of actin-based cell projections brush border apical plasma membrane brush border membrane plasma membrane bounded cell projection cell projection cell projection membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR023271	Aquaporin-like	Homologous Superfamily
A	IPR034294	Aquaporin transporter	Family
A	IPR023274	Aquaporin 1	Family
A	IPR022357	Major intrinsic protein, conserved site	Conserved Site
A	IPR000425	Major intrinsic protein	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM	Transmembrane	Alpha-helical polytopic	Major Intrinsic Protein (MIP)/FNT superfamily	Major intrinsic protein (MIP) family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Aquaporins and Glyceroporins	AQP1 aquaporin red blood cell water channel

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.