Annotations: 1IYJ

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1iyjb1	All alpha proteins	BRCA2 helical domain	BRCA2 helical domain	BRCA2 helical domain	BRCA2 helical domain	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B	d1iyjb2	All alpha proteins	BRCA2 tower domain	BRCA2 tower domain	BRCA2 tower domain	BRCA2 tower domain	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B	d1iyjb5	All beta proteins	OB-fold	Nucleic acid-binding proteins	Single strand DNA-binding domain, SSB	OB-fold domains of BRCA2, C-terminal domain	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B	d1iyjb3	All beta proteins	OB-fold	Nucleic acid-binding proteins	Single strand DNA-binding domain, SSB	OB-fold domains of BRCA2, N- and middle domain	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
D	d1iyjd1	All alpha proteins	BRCA2 helical domain	BRCA2 helical domain	BRCA2 helical domain	BRCA2 helical domain	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
D	d1iyjd2	All alpha proteins	BRCA2 tower domain	BRCA2 tower domain	BRCA2 tower domain	BRCA2 tower domain	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
D	d1iyjd5	All beta proteins	OB-fold	Nucleic acid-binding proteins	Single strand DNA-binding domain, SSB	OB-fold domains of BRCA2, C-terminal domain	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
D	d1iyjd3	All beta proteins	OB-fold	Nucleic acid-binding proteins	Single strand DNA-binding domain, SSB	OB-fold domains of BRCA2, N- and middle domain	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2 Family	DSS1/SEM1 protein family	8046893	4005354	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	DSS1/SEM1 protein family	8053396	3002183	SCOP2 (2022-06-29)
B	SCOP2 Family	BRCA2 helical domain	8030210	4002467	SCOP2 (2022-06-29)
B	SCOP2 Family	BRCA2 tower domain	8030212	4002477	SCOP2 (2022-06-29)
B	SCOP2 Family	Single strand DNA-binding domain SSB	8030213	4000346	SCOP2 (2022-06-29)
B	SCOP2 Family	Single strand DNA-binding domain SSB	8030216	4000346	SCOP2 (2022-06-29)
B	SCOP2 Family	Single strand DNA-binding domain SSB	8030217	4000346	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	BRCA2 helical domain	8042589	3001288	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	BRCA2 tower domain	8042591	3001303	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Nucleic acid-binding proteins	8042592	3000135	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Nucleic acid-binding proteins	8042595	3000135	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Nucleic acid-binding proteins	8042596	3000135	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	Nucleic acid-binding proteins	8042595	3000135	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Nucleic acid-binding proteins	8042595	3000135	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	BRCA2 helical domain	8042589	3001288	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Nucleic acid-binding proteins	8042596	3000135	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Nucleic acid-binding proteins	8042592	3000135	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	BRCA-2_OB1	e1iyjB1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: BRCA-2_OB1	ECOD (1.6)
B	BRCA-2_OB3	e1iyjB3	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: BRCA-2_OB3	ECOD (1.6)
B	BRCA2DBD_OB2	e1iyjB2	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: BRCA2DBD_OB2	ECOD (1.6)
B	BRCA-2_helical	e1iyjB4	A: alpha arrays	X: BRCA2 helical domain (From Topology)	H: BRCA2 helical domain (From Topology)	T: BRCA2 helical domain	F: BRCA-2_helical	ECOD (1.6)
B	UNK_F_TYPE	e1iyjB5	A: alpha complex topology	X: BRCA2 tower domain (From Topology)	H: BRCA2 tower domain (From Topology)	T: BRCA2 tower domain	F: UNK_F_TYPE	ECOD (1.6)
D	BRCA-2_OB1	e1iyjD1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: BRCA-2_OB1	ECOD (1.6)
D	BRCA-2_OB3	e1iyjD3	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: BRCA-2_OB3	ECOD (1.6)
D	BRCA2DBD_OB2	e1iyjD2	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: BRCA2DBD_OB2	ECOD (1.6)
D	BRCA-2_helical	e1iyjD4	A: alpha arrays	X: BRCA2 helical domain (From Topology)	H: BRCA2 helical domain (From Topology)	T: BRCA2 helical domain	F: BRCA-2_helical	ECOD (1.6)
D	UNK_F_TYPE	e1iyjD5	A: alpha complex topology	X: BRCA2 tower domain (From Topology)	H: BRCA2 tower domain (From Topology)	T: BRCA2 tower domain	F: UNK_F_TYPE	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
D	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF05160	DSS1/SEM1 family (DSS1_SEM1)	DSS1/SEM1 family	-	Family
B, D	PF09103	BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 (BRCA-2_OB1)	BRCA2, oligonucleotide/oligosaccharide-binding, domain 1	Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB1 has a shallow groove formed by one face of the curved sheet and is demarcated by two loops, one betw ...	Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB1 has a shallow groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for weak single strand DNA binding. The domain also binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome [1].	Domain
B, D	PF09169	BRCA2, helical (BRCA-2_helical)	BRCA2, helical	Members of this family adopt a helical structure, consisting of a four-helix cluster core (alpha 1, alpha 8, alpha 9, alpha 10) and two successive beta-hairpins (beta 1 to beta 4). An approx. 50-amino acid segment that contains four short helices (al ...	Members of this family adopt a helical structure, consisting of a four-helix cluster core (alpha 1, alpha 8, alpha 9, alpha 10) and two successive beta-hairpins (beta 1 to beta 4). An approx. 50-amino acid segment that contains four short helices (alpha 2 to alpha 4), meanders around the surface of the core structure. In BRCA2, the alpha 9 and alpha 10 helices pack with BRCA-2_OB1 (Pfam:PF09103) through van der Waals contacts involving hydrophobic and aromatic residues, and also through side-chain and backbone hydrogen bonds. The domain binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome [1].	Domain
B, D	PF09104	BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 (BRCA-2_OB3)	BRCA2, oligonucleotide/oligosaccharide-binding, domain 3	Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB3 has a pronounced groove formed by one face of the curved sheet and is demarcated by two loops, one b ...	Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB3 has a pronounced groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for strong ssDNA binding [1].	Domain
B, D	PF21318	BRCA2, OB2 (BRCA2DBD_OB2)	BRCA2, OB2	BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. t stimulates the displacement of Replication protein A (RPA), and also facilitates filament formation. This entry represents the second OB fold (OB2) from the ...	BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. t stimulates the displacement of Replication protein A (RPA), and also facilitates filament formation. This entry represents the second OB fold (OB2) from the C-terminal ssDNA binding domain (DBD) which has three OB folds [1]. OB2 and OB3 are arranged in tandem and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Deleted in split hand/split foot protein 1	-	cellular response to stimulus double-strand break repair response to stimulus DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress recombinational repair cellular response to stimulus double-strand break repair response to stimulus DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress recombinational repair metabolic process cellular process macromolecule metabolic process double-strand break repair via homologous recombination DNA repair organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process protein metabolic process organic substance catabolic process cellular localization nitrogen compound transport nucleocytoplasmic transport transport cellular biosynthetic process nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell organic substance biosynthetic process RNA localization nuclear export nucleobase-containing compound transport RNA transport organic substance transport cellular metabolic process nucleic acid transport intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization cellular component organization cellular component biogenesis proteasome assembly cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome regulatory particle proteasome regulatory particle, lid subcomplex proteasome accessory complex membrane-bounded organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome regulatory particle proteasome regulatory particle, lid subcomplex proteasome accessory complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
B, D	breast cancer susceptibility	catalytic activity, acting on a protein N-acetyltransferase activity acyltransferase activity histone H3 acetyltransferase activity transferase activity peptide N-acetyltransferase activity histone acetyltransferase activity acetyltransferase activity peptide-lysine-N-acetyltransferase activity histone modifying activity acyltransferase activity, transferring groups other than amino-acyl groups catalytic activity N-acyltransferase activity identical protein binding catalytic activity, acting on a protein N-acetyltransferase activity acyltransferase activity histone H3 acetyltransferase activity transferase activity peptide N-acetyltransferase activity histone acetyltransferase activity acetyltransferase activity peptide-lysine-N-acetyltransferase activity histone modifying activity acyltransferase activity, transferring groups other than amino-acyl groups catalytic activity N-acyltransferase activity identical protein binding protein binding binding enzyme binding protease binding cytoskeletal protein binding gamma-tubulin binding tubulin binding histone H4 acetyltransferase activity DNA binding organic cyclic compound binding single-stranded DNA binding nucleic acid binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process developmental process stem cell proliferation cell population proliferation cellular developmental process hemopoiesis cell differentiation anatomical structure development hematopoietic stem cell proliferation cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process developmental process stem cell proliferation cell population proliferation cellular developmental process hemopoiesis cell differentiation anatomical structure development hematopoietic stem cell proliferation cell development multicellular organism development multicellular organismal process head development central nervous system development animal organ development brain development nervous system development system development spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation DNA-templated DNA replication DNA-templated DNA replication maintenance of fidelity primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process replication fork processing establishment of organelle localization cellular localization meiotic chromosome segregation homologous chromosome orientation in meiotic metaphase I meiotic cell cycle process metaphase chromosome alignment cellular component organization localization meiotic metaphase I homologous chromosome alignment meiosis I chromosome localization organelle localization establishment of localization in cell meiotic nuclear division cell cycle cellular component organization or biogenesis chromosome segregation cell cycle process meiotic cell cycle organelle fission establishment of localization nuclear division organelle organization meiosis I cell cycle process nuclear chromosome segregation meiotic metaphase chromosome alignment homologous chromosome segregation establishment of chromosome localization response to X-ray response to ionizing radiation response to radiation response to abiotic stimulus microtubule organizing center organization microtubule cytoskeleton organization centrosome duplication centrosome cycle microtubule-based process cytoskeleton organization cellular response to ionizing radiation cellular response to radiation cellular response to abiotic stimulus cellular response to environmental stimulus mammary gland development gland development cellular metabolic process cellular senescence inner cell mass cell proliferation developmental growth chordate embryonic development growth embryo development in utero embryonic development embryo development ending in birth or egg hatching blastocyst growth blastocyst development oogenesis cellular process involved in reproduction in multicellular organism developmental maturation female gamete generation oocyte development anatomical structure maturation germ cell development oocyte maturation oocyte differentiation cell maturation regulation of cytokinesis regulation of biological process regulation of cellular process regulation of cell cycle process biological regulation cytokinesis regulation of cell division cell division regulation of cell cycle cellular biosynthetic process RNA metabolic process regulation of primary metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process nucleotide-excision repair DNA repair multicellular organism growth gonad development reproductive system development female gonad development sex differentiation female sex differentiation development of primary female sexual characteristics development of primary sexual characteristics reproductive structure development signaling DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator signal transduction by p53 class mediator DNA damage response, signal transduction by p53 class mediator intracellular signal transduction cell communication DNA damage response, signal transduction resulting in transcription signal transduction in response to DNA damage signal transduction chromosome organization DNA recombination mitotic recombination telomere organization telomere maintenance telomere maintenance via recombination negative regulation of biological process negative regulation of mammary gland epithelial cell proliferation negative regulation of cellular process regulation of multicellular organismal process epithelial cell proliferation negative regulation of cell population proliferation epithelium development tissue development regulation of mammary gland epithelial cell proliferation mammary gland epithelium development regulation of cell population proliferation regulation of epithelial cell proliferation negative regulation of multicellular organismal process negative regulation of epithelial cell proliferation mammary gland epithelial cell proliferation establishment of protein localization to telomere protein localization establishment of protein localization protein localization to chromosome, telomeric region establishment of protein localization to organelle protein localization to chromosome cellular macromolecule localization macromolecule localization protein localization to organelle establishment of protein localization to chromosome mitotic DNA replication nuclear DNA replication cell cycle DNA replication mitotic cell cycle cell cycle DNA replication maintenance of fidelity mitotic cell cycle process mitotic recombination-dependent replication fork processing mitotic DNA replication maintenance of fidelity cell death apoptotic signaling pathway intrinsic apoptotic signaling pathway in response to DNA damage apoptotic process intrinsic apoptotic signaling pathway programmed cell death double-strand break repair recombinational repair double-strand break repair via homologous recombination positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process response to gamma radiation intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator intrinsic apoptotic signaling pathway by p53 class mediator male meiosis I male meiotic nuclear division positive regulation of cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle response to nutrient levels response to chemical response to nutrient response to light stimulus response to UV-C response to UV response to organic substance response to lipid response to estradiol response to oxygen-containing compound response to organic cyclic compound	protein-containing complex catalytic complex DNA repair complex membrane-bounded organelle intracellular anatomical structure intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle protein-containing complex catalytic complex DNA repair complex membrane-bounded organelle intracellular anatomical structure intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle intracellular non-membrane-bounded organelle chromosome non-membrane-bounded organelle chromosome, telomeric region chromosomal region ubiquitin ligase complex nucleus nuclear protein-containing complex transferase complex nuclear ubiquitin ligase complex intracellular protein-containing complex BRCA2-MAGE-D1 complex centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton condensed nuclear chromosome membrane-enclosed lumen nuclear chromosome intracellular organelle lumen lateral element organelle lumen synaptonemal structure synaptonemal complex condensed chromosome nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR007834	DSS1/SEM1	Family
B, D	IPR036315	BRCA2 helical domain superfamily	Homologous Superfamily
B, D	IPR048262	BRCA2, OB2 domain	Domain
B, D	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
B, D	IPR015525	Breast cancer type 2 susceptibility protein	Family
B, D	IPR015187	BRCA2, OB1	Domain
B, D	IPR015252	Breast cancer type 2 susceptibility protein, helical domain	Domain
B, D	IPR015188	BRCA2, OB3	Domain
B, D	IPR015205	Tower domain	Domain
B, D	IPR002093	BRCA2 repeat	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C	Pharos: P60896	squamous cell carcinoma bone disease non-small cell lung carcinoma split hand-foot malformation lung cancer osteoporosis medulloblastoma pneumonia subependymal giant cell astrocytoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.