Annotations: 1INR

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1inra_	All alpha proteins	4-helical cytokines	4-helical cytokines	Interferons/interleukin-10 (IL-10)	Interleukin-10 (cytokine synthesis inhibitory factor, CSIF)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	4-helical cytokines	8037111	3001717	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	IL10	e1inrA1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: 4-helical cytokines (From Topology)	T: 4-helical cytokines	F: IL10	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1250.10	Mainly Alpha	Up-down Bundle	Growth Hormone	Chain: A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00726	Interleukin 10 (IL10)	Interleukin 10	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	INTERLEUKIN-10	protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity protein dimerization activity cytokine receptor binding growth factor receptor binding interleukin-10 receptor binding cytokine activity	response to stimulus response to chemical response to xenobiotic stimulus protein localization regulation of cellular process regulation of primary metabolic process nucleobase-containing compound metabolic process negative regulation of NF-kappaB transcription factor activity DNA-templated transcription localization regulation of RNA metabolic process cellular macromolecule localization organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process response to stimulus response to chemical response to xenobiotic stimulus protein localization regulation of cellular process regulation of primary metabolic process nucleobase-containing compound metabolic process negative regulation of NF-kappaB transcription factor activity DNA-templated transcription localization regulation of RNA metabolic process cellular macromolecule localization organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of biological process cellular metabolic process primary metabolic process regulation of cellular metabolic process maintenance of location regulation of molecular function organic cyclic compound metabolic process regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process cytoplasmic sequestering of transcription factor maintenance of protein location cellular localization cellular biosynthetic process negative regulation of DNA-binding transcription factor activity RNA metabolic process RNA biosynthetic process cytoplasmic sequestering of NF-kappaB nucleic acid biosynthetic process organic substance metabolic process cytoplasmic sequestering of protein regulation of RNA biosynthetic process regulation of biosynthetic process negative regulation of molecular function biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process macromolecule localization cellular process endothelial cell apoptotic process apoptotic process cell death programmed cell death epithelial cell apoptotic process cellular response to stimulus signaling negative regulation of signaling regulation of signaling receptor activity negative regulation of biological process negative regulation of cytokine activity regulation of signal transduction negative regulation of cell communication cell communication regulation of protein binding regulation of cytokine activity negative regulation of cellular process signal transduction regulation of signaling negative regulation of response to stimulus regulation of binding negative regulation of binding negative regulation of signal transduction negative regulation of receptor binding regulation of receptor binding negative regulation of protein binding regulation of response to stimulus regulation of cell communication multicellular organismal process negative regulation of cellular metabolic process regulation of cytokine production cytokine production regulation of multicellular organismal process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of cytokine production negative regulation of cellular biosynthetic process regulation of interleukin-18 production negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of interleukin-18 production negative regulation of multicellular organismal process interleukin-18 production negative regulation of lymphocyte proliferation regulation of leukocyte activation regulation of cell activation lymphocyte activation negative regulation of lymphocyte activation leukocyte proliferation leukocyte activation negative regulation of mononuclear cell proliferation negative regulation of leukocyte proliferation regulation of B cell proliferation lymphocyte proliferation regulation of B cell activation regulation of immune system process negative regulation of B cell activation regulation of lymphocyte proliferation regulation of leukocyte proliferation negative regulation of cell population proliferation cell population proliferation B cell activation cell activation B cell proliferation negative regulation of B cell proliferation negative regulation of cell activation negative regulation of immune system process regulation of cell population proliferation mononuclear cell proliferation immune system process regulation of mononuclear cell proliferation negative regulation of leukocyte activation regulation of lymphocyte activation regulation of tumor necrosis factor production negative regulation of tumor necrosis factor production tumor necrosis factor superfamily cytokine production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production negative regulation of tumor necrosis factor superfamily cytokine production interferon-alpha production negative regulation of type I interferon production regulation of interferon-alpha production type I interferon production negative regulation of interferon-alpha production regulation of type I interferon production interleukin-6 production regulation of interleukin-6 production negative regulation of interleukin-6 production positive regulation of DNA-binding transcription factor activity positive regulation of molecular function regulation of MHC class II biosynthetic process negative regulation of MHC class II biosynthetic process MHC class II biosynthetic process negative regulation of T cell proliferation negative regulation of cell adhesion T cell activation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion leukocyte cell-cell adhesion cell adhesion cell-cell adhesion regulation of cell-cell adhesion T cell proliferation regulation of cell adhesion regulation of T cell activation regulation of T cell proliferation developmental process cellular developmental process hemopoiesis cell differentiation anatomical structure development cell development regulation of immune effector process regulation of leukocyte differentiation mononuclear cell differentiation regulation of cell differentiation mature B cell differentiation positive regulation of B cell differentiation B cell activation involved in immune response cell activation involved in immune response lymphocyte differentiation regulation of cell development positive regulation of developmental process multicellular organism development positive regulation of cell activation regulation of plasma cell differentiation positive regulation of immune response positive regulation of leukocyte activation positive regulation of immune system process immune response positive regulation of cell development immune effector process positive regulation of plasma cell differentiation regulation of immune response positive regulation of multicellular organismal process plasma cell differentiation leukocyte differentiation regulation of developmental process positive regulation of biological process positive regulation of response to stimulus regulation of B cell differentiation positive regulation of lymphocyte activation B cell differentiation positive regulation of hemopoiesis positive regulation of cell differentiation leukocyte activation involved in immune response positive regulation of immune effector process lymphocyte activation involved in immune response positive regulation of cellular process regulation of lymphocyte differentiation regulation of multicellular organismal development mature B cell differentiation involved in immune response positive regulation of B cell activation regulation of hemopoiesis positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation response to stress regulation of response to stress response to wounding regulation of response to wounding negative regulation of cytokine production involved in immune response regulation of cytokine production involved in immune response negative regulation of immune effector process negative regulation of production of molecular mediator of immune response regulation of production of molecular mediator of immune response cytokine production involved in immune response production of molecular mediator of immune response chordate embryonic development labyrinthine layer development embryo development embryonic placenta development embryo development ending in birth or egg hatching embryonic organ development epithelium development placenta development embryonic morphogenesis animal organ development morphogenesis of an epithelium branching involved in labyrinthine layer morphogenesis tissue development in utero embryonic development embryonic placenta morphogenesis anatomical structure morphogenesis labyrinthine layer morphogenesis tissue morphogenesis morphogenesis of a branching structure morphogenesis of a branching epithelium biological process involved in interspecies interaction between organisms response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to bacterium response to external biotic stimulus regulation of cell-cell adhesion involved in gastrulation heterotypic cell-cell adhesion regulation of heterotypic cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules cell-cell adhesion involved in gastrulation gastrulation negative regulation of heterotypic cell-cell adhesion positive regulation of macromolecule biosynthetic process positive regulation of metabolic process regulation of miRNA metabolic process positive regulation of macromolecule metabolic process miRNA metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of miRNA transcription positive regulation of cellular metabolic process positive regulation of miRNA metabolic process miRNA transcription positive regulation of biosynthetic process positive regulation of RNA biosynthetic process ncRNA metabolic process positive regulation of cellular biosynthetic process regulation of miRNA transcription adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity regulation of DNA recombination leukocyte mediated immunity somatic diversification of immune receptors somatic recombination of immunoglobulin genes involved in immune response system development regulation of adaptive immune response DNA recombination DNA metabolic process regulation of B cell mediated immunity somatic diversification of immunoglobulins regulation of leukocyte mediated immunity B cell mediated immunity regulation of DNA metabolic process isotype switching immune system development immunoglobulin production immunoglobulin production involved in immunoglobulin-mediated immune response somatic cell DNA recombination somatic diversification of immunoglobulins involved in immune response somatic recombination of immunoglobulin gene segments regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of immunoglobulin mediated immune response regulation of isotype switching adaptive immune response immunoglobulin mediated immune response regulation of lymphocyte mediated immunity regulation of immunoglobulin production somatic diversification of immune receptors via germline recombination within a single locus chemokine (C-C motif) ligand 5 production negative regulation of chemokine production negative regulation of chemokine (C-C motif) ligand 5 production regulation of chemokine production chemokine production regulation of chemokine (C-C motif) ligand 5 production interleukin-1 production negative regulation of interleukin-1 production regulation of interleukin-1 production positive regulation of signaling receptor activity defense response to protozoan response to protozoan regulation of defense response chronic inflammatory response regulation of response to external stimulus negative regulation of inflammatory response regulation of chronic inflammatory response to antigenic stimulus inflammatory response to antigenic stimulus negative regulation of chronic inflammatory response negative regulation of inflammatory response to antigenic stimulus regulation of chronic inflammatory response negative regulation of immune response regulation of inflammatory response to antigenic stimulus chronic inflammatory response to antigenic stimulus negative regulation of chronic inflammatory response to antigenic stimulus regulation of inflammatory response negative regulation of response to external stimulus negative regulation of defense response inflammatory response positive regulation of immunoglobulin production positive regulation of gene expression positive regulation of production of molecular mediator of immune response type 2 immune response negative regulation of cellular catabolic process negative regulation of catabolic process catabolic process autophagy regulation of catabolic process regulation of autophagy cellular catabolic process negative regulation of autophagy regulation of cellular catabolic process process utilizing autophagic mechanism regulation of type II interferon production type II interferon production negative regulation of type II interferon production positive regulation of cell adhesion positive regulation of cell-cell adhesion positive regulation of heterotypic cell-cell adhesion negative regulation of interleukin-8 production interleukin-8 production regulation of interleukin-8 production intrinsic apoptotic signaling pathway in response to oxidative stress neuron apoptotic process regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of neuron apoptotic process negative regulation of intracellular signal transduction regulation of programmed cell death regulation of intrinsic apoptotic signaling pathway intracellular signal transduction regulation of intracellular signal transduction negative regulation of apoptotic signaling pathway intrinsic apoptotic signaling pathway regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of programmed cell death regulation of apoptotic process negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway neuron intrinsic apoptotic signaling pathway in response to oxidative stress apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway negative regulation of apoptotic process negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway regulation of neuron apoptotic process regulation of apoptotic signaling pathway cell chemotaxis chemotaxis leukocyte migration cellular response to chemical stimulus taxis cell migration cell motility leukocyte chemotaxis locomotion transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of leukocyte apoptotic process regulation of lymphocyte apoptotic process positive regulation of programmed cell death regulation of B cell apoptotic process positive regulation of lymphocyte apoptotic process leukocyte apoptotic process B cell apoptotic process positive regulation of apoptotic process lymphocyte apoptotic process positive regulation of B cell apoptotic process positive regulation of leukocyte apoptotic process regulation of vascular associated smooth muscle cell proliferation regulation of smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell proliferation smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation muscle cell proliferation vascular associated smooth muscle cell proliferation cell cycle regulation of cell cycle positive regulation of cell cycle regulation of macrophage activation positive regulation of macrophage activation myeloid leukocyte activation macrophage activation response to activity positive regulation of vascular associated smooth muscle cell proliferation positive regulation of cell population proliferation positive regulation of smooth muscle cell proliferation response to organic substance response to lipid cellular response to lipopolysaccharide response to oxygen-containing compound cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound cellular response to biotic stimulus cellular response to lipid cellular response to organic substance response to molecule of bacterial origin myeloid dendritic cell activation negative regulation of myeloid dendritic cell activation regulation of myeloid dendritic cell activation regulation of cellular component organization cellular component organization regulation of synapse organization cell junction organization regulation of synapse structure or activity synapse organization cellular component organization or biogenesis regulation of biological quality gland development animal organ regeneration liver development regeneration hepaticobiliary system development liver regeneration regulation of nitric oxide biosynthetic process negative regulation of nitric oxide metabolic process reactive nitrogen species metabolic process nitric oxide metabolic process nitric oxide biosynthetic process negative regulation of nitric oxide biosynthetic process regulation of nitric oxide metabolic process response to corticosteroid response to hormone response to steroid hormone response to endogenous stimulus response to glucocorticoid response to organic cyclic compound response to organonitrogen compound response to peptide hormone response to insulin response to nitrogen compound positive regulation of cell communication cell surface receptor signaling pathway via STAT positive regulation of signal transduction positive regulation of receptor signaling pathway via STAT positive regulation of receptor signaling pathway via JAK-STAT regulation of receptor signaling pathway via JAK-STAT cell surface receptor signaling pathway regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT positive regulation of signaling response to inactivity regulation of sprouting angiogenesis angiogenesis regulation of vasculature development tube morphogenesis positive regulation of sprouting angiogenesis regulation of anatomical structure morphogenesis blood vessel development blood vessel morphogenesis tube development positive regulation of angiogenesis sprouting angiogenesis vasculature development circulatory system development positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis response to carbon monoxide cellular response to organic cyclic compound response to estradiol cellular response to estradiol stimulus positive regulation of MHC class II biosynthetic process negative regulation of membrane protein ectodomain proteolysis negative regulation of proteolysis macromolecule catabolic process negative regulation of protein catabolic process regulation of proteolysis proteolysis membrane protein proteolysis protein metabolic process negative regulation of protein metabolic process membrane protein ectodomain proteolysis organonitrogen compound catabolic process regulation of membrane protein ectodomain proteolysis organonitrogen compound metabolic process regulation of protein metabolic process protein catabolic process organic substance catabolic process regulation of protein catabolic process positive regulation of cytokine production regulation of interleukin-12 production negative regulation of interleukin-12 production interleukin-12 production cellular response to endogenous stimulus response to hepatocyte growth factor cellular response to growth factor stimulus cellular response to hepatocyte growth factor stimulus response to growth factor endothelial cell proliferation positive regulation of epithelial cell proliferation regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of cell cycle negative regulation of mitotic cell cycle mitotic cell cycle regulation of mitotic cell cycle	extracellular region extracellular space cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR020443	Interleukin-10/19/20/22/24/26 family	Family
A	IPR020423	Interleukin-10, conserved site	Conserved Site
A	IPR000098	Interleukin-10	Family
A	IPR009079	Four-helical cytokine-like, core	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P22301	Crohn disease rheumatoid arthritis leishmaniasis HIV infectious disease glomerulonephritis Behcet disease ulcerative colitis Wilson disease pleurisy adult T-cell leukemia/lymphoma systemic lupus erythematosus inflammatory bowel disease autoimmune hepatitis colitis non-small cell lung carcinoma Crohn disease rheumatoid arthritis leishmaniasis HIV infectious disease glomerulonephritis Behcet disease ulcerative colitis Wilson disease pleurisy adult T-cell leukemia/lymphoma systemic lupus erythematosus inflammatory bowel disease autoimmune hepatitis colitis non-small cell lung carcinoma myocardial infarction Inflammation irritable bowel syndrome type 1 diabetes mellitus appendicitis multiple sclerosis cutaneous leishmaniasis prostatitis enterocolitis prostate cancer drug allergy graft versus host disease allergic contact dermatitis tuberculosis Crohn ileitis visceral leishmaniasis atopic eczema obesity disorder influenza autoimmune disease gastrointestinal mucositis heart disease lung benign neoplasm cancer schizophrenia lymphatic system disease allergic disease malaria COVID-19 Crohn's colitis neurodegenerative disease autism occupational dermatitis diarrheal disease inherited disease susceptibility pneumonia encephalitis ischemia reperfusion injury breast disease acute kidney failure burn rhinitis acute T cell leukemia cerebrovascular disorder skin disease herpes zoster lymphopenia type 2 diabetes mellitus arthritic joint disease multiple organ dysfunction syndrome hypertensive disorder inborn carbohydrate metabolic disorder atherosclerosis periodontitis digestive system neuroendocrine neoplasm kidney disease brain injury psoriasis liver disease helminthiasis adult acute respiratory distress syndrome susceptibility to HIV infection major depressive disorder coronary artery disease anemia hypereosinophilic syndrome ileocolitis asthma dermatitis, atopic

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.