1IFW

SOLUTION STRUCTURE OF C-TERMINAL DOMAIN OF POLY(A) BINDING PROTEIN FROM SACCHAROMYCES CEREVISIAE

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ifwa1	All alpha proteins	PABP domain-like	PABC (PABP) domain	PABC (PABP) domain	poly(A) binding protein	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
A	d1ifwa2	Artifacts	Tags	Tags	Tags	N-terminal Tags	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	PABC (PABP) domain	8027191	4003044	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PABC (PABP) domain	8039570	3000200	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PABP	e1ifwA1	A: alpha arrays	X: PABP domain-like	H: PABC(PABP) domain (From Topology)	T: PABC(PABP) domain	F: PABP	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.1900.10	Mainly Alpha	Orthogonal Bundle	c-terminal domain of poly(a) binding protein	c-terminal domain of poly(a) binding protein	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00658	Poly-adenylate binding protein, unique domain (PABP)	Poly-adenylate binding protein, unique domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	POLYADENYLATE-BINDING PROTEIN, CYTOPLASMIC AND NUCLEAR	molecular condensate scaffold activity protein-macromolecule adaptor activity molecular adaptor activity mRNA 3'-UTR binding RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding protein-containing complex binding chromatin binding promoter-specific chromatin binding poly(A) binding poly-purine tract binding molecular condensate scaffold activity protein-macromolecule adaptor activity molecular adaptor activity mRNA 3'-UTR binding RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding protein-containing complex binding chromatin binding promoter-specific chromatin binding poly(A) binding poly-purine tract binding single-stranded RNA binding poly-pyrimidine tract binding poly(U) RNA binding enzyme regulator activity molecular function inhibitor activity molecular function regulator activity nuclease inhibitor activity enzyme inhibitor activity ribonuclease inhibitor activity	RNA transport nitrogen compound transport transport organic substance transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport regulation of cellular process negative regulation of biological process RNA transport nitrogen compound transport transport organic substance transport nucleic acid transport mRNA transport establishment of localization localization establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological quality RNA catabolic process mRNA catabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process negative regulation of metabolic process positive regulation of mRNA metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process nucleobase-containing compound catabolic process nuclear-transcribed mRNA poly(A) tail shortening positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay catabolic process cellular biosynthetic process positive regulation of biological process RNA metabolic process macromolecule catabolic process mRNA destabilization regulation of mRNA catabolic process organic substance metabolic process negative regulation of cellular process regulation of nuclear-transcribed mRNA poly(A) tail shortening negative regulation of macromolecule metabolic process regulation of biosynthetic process nuclear-transcribed mRNA catabolic process RNA destabilization biological regulation regulation of macromolecule metabolic process regulation of catabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound catabolic process regulation of cellular biosynthetic process positive regulation of catabolic process regulation of mRNA stability negative regulation of biosynthetic process positive regulation of mRNA catabolic process regulation of RNA stability cellular process regulation of mRNA metabolic process organic substance catabolic process mRNA processing RNA processing organonitrogen compound biosynthetic process translational initiation protein metabolic process organonitrogen compound metabolic process regulation of translational initiation regulation of protein metabolic process translation regulation of translation	intracellular anatomical structure cytoplasmic ribonucleoprotein granule cellular anatomical entity ribonucleoprotein granule intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm supramolecular complex non-membrane-bounded organelle cytoplasmic stress granule cytosol ribosome protein-containing complex intracellular anatomical structure cytoplasmic ribonucleoprotein granule cellular anatomical entity ribonucleoprotein granule intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm supramolecular complex non-membrane-bounded organelle cytoplasmic stress granule cytosol ribosome protein-containing complex ribonucleoprotein complex membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR006515	Polyadenylate binding protein, human types 1, 2, 3, 4	Family
A	IPR002004	Polyadenylate-binding protein/Hyperplastic disc protein	Domain
A	IPR003954	RNA recognition motif domain, eukaryote	Domain
A	IPR000504	RNA recognition motif domain	Domain
A	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
A	IPR036053	PABC (PABP) domain	Homologous Superfamily
A	IPR034364	PABP, RNA recognition motif 1	Domain
A	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
A	IPR045305	PABP, RNA recognition motif 2	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.