Annotations: 1IF1

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C [auth A]	d1if1a_	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	Interferon regulatory factor	Interferon regulatory factor 1 (IRF-1)	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
D [auth B]	d1if1b_	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	Interferon regulatory factor	Interferon regulatory factor 1 (IRF-1)	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth A]	SCOP2 Family	IRF DNA-binding domain-like	8003175	4000230	SCOP2 (2022-06-29)
C [auth A]	SCOP2 Superfamily	Winged helix DNA-binding domain	8003176	3000034	SCOP2 (2022-06-29)
D [auth B]	SCOP2B Superfamily	Winged helix DNA-binding domain	8003176	3000034	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth A]	PF00605	e1if1A1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF00605	ECOD (1.6)
D [auth B]	PF00605	e1if1B1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF00605	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth A]	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
D [auth B]	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth A], D [auth B]	PF00605	Interferon regulatory factor transcription factor (IRF)	Interferon regulatory factor transcription factor	This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], B [auth D]	DNA (26-MER)	-	-	-
C [auth A], D [auth B]	PROTEIN (INTERFERON REGULATORY FACTOR 1)	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding	cellular response to stimulus cellular response to nitrogen compound response to organic substance response to stimulus response to endogenous stimulus response to organonitrogen compound response to peptide hormone cellular response to peptide hormone stimulus response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound response to hormone cellular response to stimulus cellular response to nitrogen compound response to organic substance response to stimulus response to endogenous stimulus response to organonitrogen compound response to peptide hormone cellular response to peptide hormone stimulus response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound response to hormone response to chemical cellular process cellular response to organic substance cellular response to hormone stimulus regulation of biosynthetic process regulation of biological process regulation of cellular process cellular biosynthetic process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organic substance metabolic process biosynthetic process organic substance biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process apoptotic process cell death programmed cell death positive regulation of programmed cell death regulation of apoptotic process positive regulation of biological process regulation of programmed cell death positive regulation of apoptotic process positive regulation of cellular process regulation of adaptive immune response immune response regulation of response to stimulus immune system process regulation of immune response regulation of immune system process adaptive immune response regulation of alpha-beta T cell activation regulation of leukocyte activation regulation of cell activation alpha-beta T cell differentiation involved in immune response regulation of cell development negative regulation of cell adhesion multicellular organism development negative regulation of T cell differentiation type 2 immune response T cell activation cell differentiation regulation of T-helper cell differentiation regulation of type 2 immune response alpha-beta T cell activation T-helper cell differentiation negative regulation of leukocyte differentiation negative regulation of immune effector process immune effector process negative regulation of type 2 immune response negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of multicellular organismal process regulation of developmental process cell development CD4-positive, alpha-beta T cell differentiation negative regulation of T-helper 2 cell differentiation regulation of T cell differentiation alpha-beta T cell differentiation T cell activation involved in immune response leukocyte activation involved in immune response regulation of T-helper 2 cell differentiation regulation of cell-cell adhesion negative regulation of cell differentiation hemopoiesis negative regulation of developmental process regulation of cell adhesion cell activation negative regulation of cell development regulation of CD4-positive, alpha-beta T cell activation negative regulation of alpha-beta T cell activation regulation of lymphocyte activation multicellular organismal process regulation of immune effector process regulation of leukocyte differentiation negative regulation of biological process mononuclear cell differentiation regulation of cell differentiation lymphocyte differentiation cell activation involved in immune response CD4-positive, alpha-beta T cell differentiation involved in immune response anatomical structure development T cell differentiation negative regulation of hemopoiesis developmental process negative regulation of immune response negative regulation of CD4-positive, alpha-beta T cell activation negative regulation of lymphocyte differentiation negative regulation of CD4-positive, alpha-beta T cell differentiation negative regulation of leukocyte activation leukocyte differentiation cellular developmental process regulation of CD4-positive, alpha-beta T cell differentiation regulation of alpha-beta T cell differentiation lymphocyte activation negative regulation of alpha-beta T cell differentiation negative regulation of lymphocyte activation leukocyte cell-cell adhesion leukocyte activation cell adhesion cell-cell adhesion alpha-beta T cell activation involved in immune response CD4-positive, alpha-beta T cell activation negative regulation of cellular process T-helper 2 cell differentiation regulation of multicellular organismal process lymphocyte activation involved in immune response regulation of lymphocyte differentiation regulation of multicellular organismal development negative regulation of response to stimulus regulation of T cell activation T cell differentiation involved in immune response negative regulation of T-helper cell differentiation negative regulation of cell activation negative regulation of immune system process regulation of hemopoiesis positive regulation of response to biotic stimulus pattern recognition receptor signaling pathway regulation of MyD88-dependent toll-like receptor signaling pathway toll-like receptor signaling pathway regulation of signal transduction response to biotic stimulus cell communication immune response-activating signaling pathway positive regulation of immune response signal transduction positive regulation of immune system process innate immune response-activating signaling pathway response to other organism regulation of innate immune response response to external stimulus defense response to other organism regulation of pattern recognition receptor signaling pathway positive regulation of defense response activation of innate immune response regulation of toll-like receptor signaling pathway activation of immune response regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus signaling positive regulation of response to stimulus positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress response to stress innate immune response response to external biotic stimulus MyD88-dependent toll-like receptor signaling pathway regulation of signaling positive regulation of innate immune response defense response defense response to symbiont regulation of cell communication response to interferon-beta response to cytokine cellular response to interferon-beta cellular response to cytokine stimulus response to type II interferon cytokine-mediated signaling pathway cellular response to type II interferon interferon-mediated signaling pathway cell surface receptor signaling pathway type II interferon-mediated signaling pathway response to growth hormone cytoplasmic pattern recognition receptor signaling pathway intracellular receptor signaling pathway endolysosomal toll-like receptor signaling pathway toll-like receptor 3 signaling pathway defense response to virus response to virus positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process cytokine production regulation of cytokine production positive regulation of macromolecule metabolic process positive regulation of type I interferon production type I interferon production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of cytokine production positive regulation of cellular biosynthetic process regulation of type I interferon production regulation of primary metabolic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process primary metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA biosynthetic process cellular response to interleukin-1 response to interleukin-1 CD8-positive, alpha-beta T cell activation CD8-positive, alpha-beta T cell proliferation leukocyte proliferation regulation of alpha-beta T cell proliferation alpha-beta T cell proliferation lymphocyte proliferation T cell proliferation regulation of lymphocyte proliferation regulation of leukocyte proliferation regulation of CD8-positive, alpha-beta T cell proliferation cell population proliferation regulation of T cell proliferation mononuclear cell proliferation regulation of cell population proliferation regulation of mononuclear cell proliferation regulation of CD8-positive, alpha-beta T cell activation negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process canonical NF-kappaB signal transduction intracellular signal transduction intracellular signaling cassette adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of T cell differentiation positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of cell development T-helper 1 type immune response regulation of T-helper 1 type immune response regulation of T-helper 1 cell differentiation positive regulation of alpha-beta T cell differentiation positive regulation of leukocyte cell-cell adhesion positive regulation of T-helper cell differentiation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell differentiation positive regulation of immune effector process positive regulation of T-helper 1 cell differentiation positive regulation of developmental process positive regulation of cell activation positive regulation of leukocyte activation positive regulation of T cell activation positive regulation of alpha-beta T cell activation positive regulation of CD4-positive, alpha-beta T cell activation regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of hemopoiesis positive regulation of cell adhesion T-helper 1 cell differentiation positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation regulation of interleukin-12 production interleukin-12 production positive regulation of interleukin-12 production regulation of interferon-beta production interferon-beta production positive regulation of interferon-beta production regulation of natural killer cell activation natural killer cell differentiation positive regulation of natural killer cell activation natural killer cell activation regulation of natural killer cell differentiation positive regulation of natural killer cell differentiation cellular response to tumor necrosis factor response to tumor necrosis factor regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process negative regulation of protein modification process regulation of receptor signaling pathway via JAK-STAT protein modification process phosphorus metabolic process negative regulation of protein metabolic process tyrosine phosphorylation of STAT protein negative regulation of receptor signaling pathway via JAK-STAT protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of protein phosphorylation macromolecule modification regulation of phosphorus metabolic process regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via STAT regulation of protein modification process regulation of protein phosphorylation negative regulation of signaling negative regulation of phosphate metabolic process peptidyl-tyrosine modification negative regulation of cell communication protein metabolic process negative regulation of peptidyl-tyrosine phosphorylation organonitrogen compound metabolic process regulation of tyrosine phosphorylation of STAT protein regulation of peptidyl-tyrosine phosphorylation negative regulation of signal transduction negative regulation of tyrosine phosphorylation of STAT protein negative regulation of phosphorus metabolic process regulation of phosphorylation negative regulation of phosphorylation peptidyl-tyrosine phosphorylation negative regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT response to mechanical stimulus response to abiotic stimulus cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus CD8-positive, alpha-beta T cell differentiation cell cycle regulation of cell cycle negative regulation of regulatory T cell differentiation regulation of regulatory T cell differentiation regulatory T cell differentiation	intracellular anatomical structure cytoplasm cellular anatomical entity intracellular organelle protein-containing complex protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth A], D [auth B]	IPR019817	Interferon regulatory factor, conserved site	Conserved Site
C [auth A], D [auth B]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
C [auth A], D [auth B]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
C [auth A], D [auth B]	IPR001346	Interferon regulatory factor, DNA-binding domain	Domain
C [auth A], D [auth B]	IPR017431	Interferon regulatory factor-1/2	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.