1IB1

CRYSTAL STRUCTURE OF THE 14-3-3 ZETA:SEROTONIN N-ACETYLTRANSFERASE COMPLEX

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ib1a_	All alpha proteins	alpha-alpha superhelix	14-3-3 protein	14-3-3 protein	zeta isoform	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1ib1b_	All alpha proteins	alpha-alpha superhelix	14-3-3 protein	14-3-3 protein	zeta isoform	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1ib1c_	All alpha proteins	alpha-alpha superhelix	14-3-3 protein	14-3-3 protein	zeta isoform	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1ib1d_	All alpha proteins	alpha-alpha superhelix	14-3-3 protein	14-3-3 protein	zeta isoform	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d1ib1e_	Alpha and beta proteins (a+b)	Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	N-acetyl transferase, NAT	Serotonin N-acetyltranferase	sheep (Ovis aries ) [TaxId: 9940 ],	SCOPe (2.08)
F	d1ib1f_	Alpha and beta proteins (a+b)	Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	N-acetyl transferase, NAT	Serotonin N-acetyltranferase	sheep (Ovis aries ) [TaxId: 9940 ],	SCOPe (2.08)
G	d1ib1g_	Alpha and beta proteins (a+b)	Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	N-acetyl transferase, NAT	Serotonin N-acetyltranferase	sheep (Ovis aries ) [TaxId: 9940 ],	SCOPe (2.08)
H	d1ib1h_	Alpha and beta proteins (a+b)	Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	N-acetyl transferase, NAT	Serotonin N-acetyltranferase	sheep (Ovis aries ) [TaxId: 9940 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	14-3-3 protein	8034961	3001329	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	14-3-3 protein	8034961	3001329	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	14-3-3 protein	8034961	3001329	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	14-3-3 protein	8034961	3001329	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8036037	3000403	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8036037	3000403	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8036037	3000403	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8036037	3000403	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	14-3-3	e1ib1A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: 14-3-3	ECOD (1.6)
B	14-3-3	e1ib1B1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: 14-3-3	ECOD (1.6)
C	14-3-3	e1ib1C1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: 14-3-3	ECOD (1.6)
D	14-3-3	e1ib1D1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: 14-3-3	ECOD (1.6)
E	Acetyltransf_10_5	e1ib1E1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_10_5	ECOD (1.6)
F	Acetyltransf_10_5	e1ib1F1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_10_5	ECOD (1.6)
G	Acetyltransf_10_5	e1ib1G1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_10_5	ECOD (1.6)
H	Acetyltransf_10_5	e1ib1H1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_10_5	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.190.20	Mainly Alpha	Up-down Bundle	Delta-Endotoxin	domain 1	CATH (4.3.0)
B	1.20.190.20	Mainly Alpha	Up-down Bundle	Delta-Endotoxin	domain 1	CATH (4.3.0)
C	1.20.190.20	Mainly Alpha	Up-down Bundle	Delta-Endotoxin	domain 1	CATH (4.3.0)
D	1.20.190.20	Mainly Alpha	Up-down Bundle	Delta-Endotoxin	domain 1	CATH (4.3.0)
E	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)
F	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)
G	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)
H	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00244	14-3-3 protein (14-3-3)	14-3-3 protein	-	Repeat
E, F, G, H	PF00583	Acetyltransferase (GNAT) family (Acetyltransf_1)	Acetyltransferase (GNAT) family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	14-3-3 ZETA ISOFORM	phosphoprotein binding protein binding binding phosphoserine residue binding protein phosphorylated amino acid binding molecular sequestering activity protein sequestering activity RNA binding organic cyclic compound binding nucleic acid binding transmembrane transporter binding kinase binding enzyme binding protein kinase binding phosphoprotein binding protein binding binding phosphoserine residue binding protein phosphorylated amino acid binding molecular sequestering activity protein sequestering activity RNA binding organic cyclic compound binding nucleic acid binding transmembrane transporter binding kinase binding enzyme binding protein kinase binding cell adhesion molecule binding cadherin binding transcription factor binding DNA-binding transcription factor binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding identical protein binding	Golgi localization establishment of organelle localization localization cellular localization establishment of Golgi localization organelle localization establishment of localization in cell cellular process establishment of localization regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation Golgi localization establishment of organelle localization localization cellular localization establishment of Golgi localization organelle localization establishment of localization in cell cellular process establishment of localization regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus cellular response to stress response to stress response to starvation cellular response to glucose starvation cellular response to starvation regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms negative regulation of response to biotic stimulus regulation of response to external stimulus response to biotic stimulus regulation of response to stress innate immune response regulation of immune system process response to external biotic stimulus negative regulation of response to stimulus immune response response to other organism defense response regulation of innate immune response negative regulation of immune response defense response to symbiont response to external stimulus regulation of response to stimulus negative regulation of immune system process immune system process defense response to other organism negative regulation of response to external stimulus negative regulation of defense response regulation of immune response negative regulation of innate immune response Golgi inheritance organelle inheritance Golgi reassembly cellular component organization cellular component biogenesis organelle organization cellular component assembly cellular component organization or biogenesis Golgi organization endomembrane system organization signaling signal transduction cell communication developmental process multicellular organismal process regulation of cellular component organization regulation of developmental process nervous system development developmental maturation synapse maturation regulation of synapse organization multicellular organism development regulation of synapse maturation cell junction organization anatomical structure development regulation of synapse structure or activity synapse organization regulation of biological quality system development protein phosphorylation organonitrogen compound metabolic process phosphorylation cellular metabolic process primary metabolic process organic substance metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process regulation of signaling regulation of signal transduction regulation of MAPK cascade intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of cell communication negative regulation of TORC1 signaling negative regulation of TOR signaling regulation of TORC1 signaling TOR signaling regulation of TOR signaling negative regulation of signal transduction TORC1 signaling protein localization regulation of localization regulation of protein localization regulation of protein localization to nucleus protein localization to nucleus negative regulation of protein localization to nucleus regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to organelle negative regulation of protein localization negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cytoplasm vesicle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cytosol nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen synapse glutamatergic synapse blood microparticle
E, F, G, H	SEROTONIN N-ACETYLTRANSFERASE	aralkylamine N-acetyltransferase activity acetyltransferase activity N-acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity N-acyltransferase activity	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein acylation protein maturation protein acetylation organic substance metabolic process biosynthetic process N-terminal protein amino acid modification macromolecule modification N-terminal protein amino acid acetylation organic substance biosynthetic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein acylation protein maturation protein acetylation organic substance metabolic process biosynthetic process N-terminal protein amino acid modification macromolecule modification N-terminal protein amino acid acetylation organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process rhythmic process circadian rhythm cellular response to stimulus cellular response to nitrogen compound response to organic substance response to stimulus response to organonitrogen compound response to endogenous stimulus response to organophosphorus cellular response to organic cyclic compound response to oxygen-containing compound response to nitrogen compound response to purine-containing compound response to cAMP cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound response to chemical cellular response to cAMP cellular response to organic substance response to organic cyclic compound regulation of hormone levels biological regulation organonitrogen compound biosynthetic process indole-containing compound metabolic process amide biosynthetic process hormone metabolic process melatonin metabolic process organic cyclic compound metabolic process indole-containing compound biosynthetic process organic cyclic compound biosynthetic process amide metabolic process regulation of biological quality melatonin biosynthetic process hormone biosynthetic process	intracellular anatomical structure perinuclear region of cytoplasm cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR023409	14-3-3 protein, conserved site	Conserved Site
A, B, C, D	IPR023410	14-3-3 domain	Domain
A, B, C, D	IPR036815	14-3-3 domain superfamily	Homologous Superfamily
A, B, C, D	IPR000308	14-3-3 protein	Family
E, F, G, H	IPR016181	Acyl-CoA N-acyltransferase	Homologous Superfamily
E, F, G, H	IPR000182	GNAT domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P63104	Mammary Neoplasms, Experimental Parkinson disease carcinoma sarcomatoid carcinoma mammary neoplasms, animal myopathy ovarian cancer paranoid schizophrenia plasma cell myeloma undifferentiated carcinoma atypical teratoid rhabdoid tumor breast carcinoma Creutzfeldt Jacob disease invasive ductal breast carcinoma lung adenocarcinoma Mammary Neoplasms, Experimental Parkinson disease carcinoma sarcomatoid carcinoma mammary neoplasms, animal myopathy ovarian cancer paranoid schizophrenia plasma cell myeloma undifferentiated carcinoma atypical teratoid rhabdoid tumor breast carcinoma Creutzfeldt Jacob disease invasive ductal breast carcinoma lung adenocarcinoma malignant glioma pancreatic ductal adenocarcinoma primitive neuroectodermal tumor bipolar disorder glioblastoma large cell medulloblastoma lung cancer medulloblastoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma astrocytic tumor breast cancer IgA glomerulonephritis malignant ependymoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
E, F, G, H	TPO	Parent Component: THR RESID: AA0038 PSI-MOD : O-phospho-L-threonine MOD:00047

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.