Annotations: 1I5H

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth W]	d1i5hw_	All beta proteins	WW domain-like	WW domain	WW domain	Ubiquitin ligase NEDD4 WWIII domain	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth W]	SCOP2 Family	WW domain	8067153	4002695	SCOP2 (2022-06-29)
A [auth W]	SCOP2 Superfamily	WW domain	8067154	3001621	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth W]	WW	e1i5hW1	A: beta meanders	X: WW domain-like	H: WW domain (From Topology)	T: WW domain	F: WW	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth W]	2.20.70.10	Mainly Beta	Single Sheet	Ubiquitin Ligase Nedd4	Chain: W	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth W]	PF00397	WW domain (WW)	WW domain	The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth W]	UBIQUITIN LIGASE NEDD4	molecular function inhibitor activity sodium channel inhibitor activity channel regulator activity transporter inhibitor activity ion channel regulator activity ion channel inhibitor activity molecular function regulator activity sodium channel regulator activity transporter regulator activity channel inhibitor activity beta-2 adrenergic receptor binding protein binding binding adrenergic receptor binding molecular function inhibitor activity sodium channel inhibitor activity channel regulator activity transporter inhibitor activity ion channel regulator activity ion channel inhibitor activity molecular function regulator activity sodium channel regulator activity transporter regulator activity channel inhibitor activity beta-2 adrenergic receptor binding protein binding binding adrenergic receptor binding signaling receptor binding G protein-coupled receptor binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity proline-rich region binding protein domain specific binding phosphoprotein binding phosphoserine residue binding protein phosphorylated amino acid binding RNA polymerase binding enzyme binding ubiquitin binding ubiquitin-like protein binding ionotropic glutamate receptor binding glutamate receptor binding phosphothreonine residue binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process immune response immune system process adaptive immune response localization import into cell receptor internalization transport receptor-mediated endocytosis cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process immune response immune system process adaptive immune response localization import into cell receptor internalization transport receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process biological process involved in interspecies interaction between organisms response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to other organism innate immune response response to external biotic stimulus protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of localization regulation of biological process regulation of transport regulation of monoatomic ion transport negative regulation of monoatomic ion transport biological regulation negative regulation of biological process negative regulation of transport regulation of sodium ion transport metal ion transport monoatomic ion transport negative regulation of sodium ion transport monoatomic cation transport regulation of metal ion transport sodium ion transport regulation of cellular process cellular response to growth factor stimulus signaling negative regulation of signaling regulation of signal transduction negative regulation of cellular response to growth factor stimulus cell surface receptor protein tyrosine kinase signaling pathway negative regulation of cell communication cell communication regulation of vascular endothelial growth factor receptor signaling pathway cellular response to endogenous stimulus negative regulation of vascular endothelial growth factor receptor signaling pathway negative regulation of cellular process signal transduction enzyme-linked receptor protein signaling pathway regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus negative regulation of signal transduction vascular endothelial growth factor receptor signaling pathway regulation of response to stimulus regulation of cell communication response to growth factor regulation of biological quality regulation of membrane potential monoatomic ion transmembrane transport regulation of monoatomic ion transmembrane transport transmembrane transport regulation of transmembrane transport response to organic substance intracellular receptor signaling pathway response to lipid progesterone receptor signaling pathway hormone-mediated signaling pathway response to hormone response to steroid hormone cellular response to organic substance cellular response to steroid hormone stimulus response to organic cyclic compound cellular response to hormone stimulus cellular response to organic cyclic compound cellular response to chemical stimulus steroid hormone mediated signaling pathway response to chemical cellular response to lipid nuclear receptor signaling pathway intracellular steroid hormone receptor signaling pathway negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process protein monoubiquitination regulation of muscle adaptation multicellular organismal process system process regulation of system process regulation of muscle system process muscle system process response to muscle inactivity response to stimulus involved in regulation of muscle adaptation muscle adaptation response to denervation involved in regulation of muscle adaptation response to muscle inactivity involved in regulation of muscle adaptation response to inactivity regulation of multicellular organismal process developmental process blood vessel morphogenesis tube development vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis anatomical structure development blood vessel development system development plasma membrane bounded cell projection organization cellular developmental process cell projection organization cell development neuron projection development nervous system development cellular component organization generation of neurons neurogenesis neuron differentiation cell differentiation neuron development cellular component organization or biogenesis heart development animal organ development mesenchyme development tissue development endocardial cushion development receptor catabolic process cellular catabolic process receptor metabolic process cellular localization regulation of cellular component organization postsynaptic neurotransmitter receptor internalization regulation of receptor internalization vesicle-mediated transport in synapse establishment of localization in cell regulation of postsynaptic neurotransmitter receptor internalization regulation of endocytosis regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport protein-containing complex localization neurotransmitter receptor internalization regulation of postsynaptic membrane neurotransmitter receptor levels postsynaptic endocytosis nucleocytoplasmic transport positive regulation of nucleocytoplasmic transport nuclear transport positive regulation of biological process intracellular transport regulation of nucleocytoplasmic transport positive regulation of transport regulation of cellular localization positive regulation of intracellular transport positive regulation of cellular process regulation of intracellular transport regulation protein catabolic process at synapse regulation of catabolic process regulation protein catabolic process at postsynapse cell junction organization neuromuscular junction development synapse organization positive regulation of protein metabolic process positive regulation of metabolic process positive regulation of macromolecule metabolic process regulation of protein metabolic process positive regulation of protein catabolic process positive regulation of catabolic process regulation of protein catabolic process regulation of synapse organization regulation of synapse structure or activity positive regulation of cell communication regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signaling intracellular corticosteroid receptor signaling pathway intracellular glucocorticoid receptor signaling pathway T cell activation cell activation lymphocyte activation leukocyte activation modulation of chemical synaptic transmission regulation of protein catabolic process at postsynapse, modulating synaptic transmission synaptic signaling postsynaptic modulation of chemical synaptic transmission trans-synaptic signaling cell-cell signaling chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling protein polyubiquitination protein K63-linked ubiquitination response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to light stimulus response to radiation response to abiotic stimulus cellular response to abiotic stimulus cellular response to UV vacuolar transport lysosomal transport regulation of neuron projection development regulation of developmental process plasma membrane bounded cell projection morphogenesis cell morphogenesis cell projection morphogenesis dendrite development neuron projection morphogenesis regulation of dendrite morphogenesis regulation of anatomical structure morphogenesis regulation of cell projection organization dendrite morphogenesis cell morphogenesis involved in neuron differentiation regulation of dendrite development regulation of plasma membrane bounded cell projection organization protein localization establishment of protein localization nitrogen compound transport protein targeting establishment of protein localization to vacuole protein targeting to lysosome cellular macromolecule localization protein targeting to vacuole organic substance transport protein localization to vacuole protein localization to lysosome establishment of protein localization to organelle protein transport protein localization to organelle macromolecule localization intracellular protein transport heart morphogenesis outflow tract morphogenesis animal organ morphogenesis	membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol intracellular organelle protein-containing complex protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle synapse membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol intracellular organelle protein-containing complex protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle synapse cell junction glutamatergic synapse membrane-bounded organelle Golgi apparatus intracellular membrane-bounded organelle endomembrane system neuron spine neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection postsynapse dendrite dendritic tree actin-based cell projection microvillus perinuclear region of cytoplasm ubiquitin ligase complex catalytic complex transferase complex intracellular protein-containing complex cell periphery cell cortex plasma membrane nucleus cytosolic region postsynaptic cytosol
B	AMILORIDE-SENSITIVE SODIUM CHANNEL BETA-SUBUNIT	monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity ligand-gated sodium channel activity sodium channel activity sodium ion transmembrane transporter activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity ligand-gated sodium channel activity sodium channel activity sodium ion transmembrane transporter activity ligand-gated channel activity ligand-gated monoatomic ion channel activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity ligand-gated monoatomic cation channel activity transmembrane transporter activity protein binding binding WW domain binding protein domain specific binding	response to stimulus response to chemical response to xenobiotic stimulus sodium ion homeostasis inorganic ion homeostasis homeostatic process intracellular sodium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis response to stimulus response to chemical response to xenobiotic stimulus sodium ion homeostasis inorganic ion homeostasis homeostatic process intracellular sodium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis multicellular organismal process system process circulatory system process regulation of blood pressure biological regulation regulation of biological quality blood circulation renal system process sensory perception of chemical stimulus sensory perception nervous system process sensory perception of taste sensory perception of sour taste neutrophil-mediated killing of symbiont cell biological process involved in interspecies interaction between organisms disruption of cell in another organism response to biotic stimulus myeloid leukocyte mediated immunity biological process involved in symbiotic interaction defense response to bacterium neutrophil mediated immunity response to stress response to bacterium leukocyte mediated immunity response to external biotic stimulus biological process involved in interaction with symbiont killing of cells of another organism neutrophil-mediated killing of bacterium neutrophil mediated cytotoxicity response to other organism defense response response to external stimulus defense response to symbiont leukocyte mediated cytotoxicity immune effector process killing by host of symbiont cells defense response to other organism immune system process cellular process disruption of anatomical structure in another organism cell killing localization epithelial fluid transport transport transepithelial transport fluid transport establishment of localization cellular response to stimulus response to organic substance response to ketone response to lipid cellular response to mineralocorticoid stimulus response to mineralocorticoid cellular response to endogenous stimulus cellular response to aldehyde response to hormone response to steroid hormone cellular response to organic substance cellular response to ketone response to organic cyclic compound cellular response to steroid hormone stimulus cellular response to hormone stimulus cellular response to aldosterone response to aldosterone response to endogenous stimulus response to alcohol cellular response to organic cyclic compound response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to corticosteroid stimulus response to corticosteroid cellular response to chemical stimulus cellular response to alcohol cellular response to lipid cellular response to nitrogen compound cellular response to vasopressin response to organonitrogen compound response to peptide hormone cellular response to peptide hormone stimulus response to nitrogen compound response to vasopressin cellular response to organonitrogen compound response to pH cellular response to pH response to abiotic stimulus cellular response to acidic pH cellular response to abiotic stimulus response to acidic pH cellular response to environmental stimulus multicellular organismal-level homeostasis homeostasis of number of cells myeloid cell homeostasis erythrocyte homeostasis regulation of body fluid levels secretion by tissue secretion mucus secretion body fluid secretion multicellular organismal-level water homeostasis multicellular organismal-level chemical homeostasis sensory perception of salty taste monoatomic ion transmembrane transport sodium ion transmembrane transport inorganic ion transmembrane transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport monoatomic ion transport monoatomic cation transport sodium ion transport import into cell import across plasma membrane sodium ion import across plasma membrane inorganic cation import across plasma membrane inorganic ion import across plasma membrane organic substance metabolic process biosynthetic process cellular biosynthetic process cellular metabolic process organic substance biosynthetic process metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process developmental process wound healing epithelium development morphogenesis of an epithelium epiboly involved in wound healing tissue development morphogenesis of an epithelial sheet wound healing, spreading of epidermal cells tissue morphogenesis anatomical structure morphogenesis anatomical structure development epiboly cell migration wound healing, spreading of cells cell motility response to wounding potassium ion homeostasis regulation of hormone levels organic hydroxy compound metabolic process steroid metabolic process alcohol metabolic process primary metabolic process C21-steroid hormone metabolic process hormone metabolic process mineralocorticoid metabolic process organic cyclic compound metabolic process cellular ketone metabolic process aldosterone metabolic process cellular aldehyde metabolic process olefinic compound metabolic process small molecule metabolic process primary alcohol metabolic process lipid metabolic process response to decreased oxygen levels response to hypoxia response to oxygen levels regulation of tube diameter vascular associated smooth muscle contraction regulation of tube size muscle contraction muscle system process smooth muscle contraction artery smooth muscle contraction vascular process in circulatory system blood vessel diameter maintenance tonic smooth muscle contraction vasoconstriction regulation of anatomical structure size leukocyte activation involved in inflammatory response cell activation inflammatory response leukocyte activation multicellular organism growth developmental growth growth regulation of localization regulation of biological process regulation of transport regulation of monoatomic ion transport regulation of sodium ion transport regulation of metal ion transport response to nutrient levels response to food neutrophil activation immune response cell activation involved in immune response myeloid leukocyte activation myeloid cell activation involved in immune response neutrophil activation involved in immune response leukocyte activation involved in immune response granulocyte activation	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane apical part of cell plasma membrane region apical plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane apical part of cell plasma membrane region apical plasma membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle protein-containing complex sodium channel complex transmembrane transporter complex membrane protein complex cation channel complex transporter complex monoatomic ion channel complex intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle cytoplasm organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth W]	IPR035983	HECT, E3 ligase catalytic domain	Homologous Superfamily
A [auth W]	IPR036020	WW domain superfamily	Homologous Superfamily
A [auth W]	IPR000008	C2 domain	Domain
A [auth W]	IPR000569	HECT domain	Domain
A [auth W]	IPR024928	E3 ubiquitin-protein ligase, SMURF1 type	Family
A [auth W]	IPR035892	C2 domain superfamily	Homologous Superfamily
A [auth W]	IPR001202	WW domain	Domain
B	IPR020903	Epithelial sodium channel, conserved site	Conserved Site
B	IPR004724	Epithelial sodium channel, chordates	Family
B	IPR001873	Epithelial sodium channel	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.