Annotations: 1HYK

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1hyka_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Agouti-related protein	Agouti-related protein	Agouti-related protein	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Agouti-related protein	8025738	4003097	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Agouti-related protein	8038117	3000249	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF05039	e1hykA1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: omega toxin-related	F: PF05039	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	4.10.760.10	Few Secondary Structures	Irregular	Agouti Related Protein	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF05039	Agouti protein (Agouti)	Agouti protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	AGOUTI RELATED PROTEIN	protein binding binding signaling receptor binding melanocortin receptor binding G protein-coupled receptor binding neuropeptide receptor binding type 1 melanocortin receptor binding molecular function activator activity neuropeptide activity signaling receptor activator activity hormone activity molecular function regulator activity neuropeptide hormone activity signaling receptor regulator activity protein binding binding signaling receptor binding melanocortin receptor binding G protein-coupled receptor binding neuropeptide receptor binding type 1 melanocortin receptor binding molecular function activator activity neuropeptide activity signaling receptor activator activity hormone activity molecular function regulator activity neuropeptide hormone activity signaling receptor regulator activity receptor ligand activity	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cell communication G protein-coupled receptor signaling pathway cellular process signal transduction neuropeptide signaling pathway rhythmic process circadian rhythm response to organic substance cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cell communication G protein-coupled receptor signaling pathway cellular process signal transduction neuropeptide signaling pathway rhythmic process circadian rhythm response to organic substance response to hormone response to chemical response to endogenous stimulus response to organonitrogen compound response to peptide hormone response to insulin response to oxygen-containing compound response to nitrogen compound response to light stimulus photoperiodism response to radiation response to abiotic stimulus long-day photoperiodism hormone-mediated signaling pathway cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organic substance cellular response to hormone stimulus multi-multicellular organism process multicellular organismal process maternal process involved in female pregnancy reproductive process multicellular organismal reproductive process female pregnancy multi-organism reproductive process positive regulation of feeding behavior positive regulation of biological process feeding behavior regulation of behavior behavior positive regulation of behavior positive regulation of multicellular organismal process regulation of multicellular organismal process regulation of feeding behavior eating behavior adult feeding behavior adult behavior	membrane-bounded organelle intracellular anatomical structure Golgi apparatus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle organelle lumen organelle cytoplasm somatodendritic compartment membrane-bounded organelle intracellular anatomical structure Golgi apparatus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle organelle lumen organelle cytoplasm somatodendritic compartment cell body neuronal cell body extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR027300	Agouti domain	Domain
A	IPR036836	Agouti domain superfamily	Homologous Superfamily
A	IPR007733	Agouti	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O00253	obesity disorder monogenic obesity acquired metabolic disease inborn carbohydrate metabolic disorder type 2 diabetes mellitus DOID:0081062 eating disorder

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.