Annotations: 1HY3

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1hy3a_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	PAPS sulfotransferase	Estrogen sulfotransferase (STE, sult1e1)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1hy3b_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	PAPS sulfotransferase	Estrogen sulfotransferase (STE, sult1e1)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	P-loop nucleotide/nucleoside kinase-like	8057094	3002021	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	P-loop nucleotide/nucleoside kinase-like	8057094	3002021	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Sulfotransfer_1	e1hy3A1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Sulfotransfer_1	ECOD (1.6)
B	Sulfotransfer_1	e1hy3B1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Sulfotransfer_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
B	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00685	Sulfotransferase domain (Sulfotransfer_1)	Sulfotransferase domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	ESTROGEN SULFOTRANSFERASE	flavonol 3-sulfotransferase activity transferase activity, transferring sulphur-containing groups sulfotransferase activity transferase activity catalytic activity aryl sulfotransferase activity binding organic cyclic compound binding steroid binding lipid binding steroid sulfotransferase activity estrone sulfotransferase activity	catabolic process lipid catabolic process regulation of hormone levels steroid metabolic process biological regulation primary metabolic process hormone metabolic process organic cyclic compound catabolic process estrogen metabolic process organic cyclic compound metabolic process organic substance metabolic process steroid catabolic process estrogen catabolic process metabolic process catabolic process lipid catabolic process regulation of hormone levels steroid metabolic process biological regulation primary metabolic process hormone metabolic process organic cyclic compound catabolic process estrogen metabolic process organic cyclic compound metabolic process organic substance metabolic process steroid catabolic process estrogen catabolic process metabolic process regulation of biological quality organic substance catabolic process hormone catabolic process lipid metabolic process cellular metabolic process sulfur compound metabolic process cellular process sulfation ribose phosphate metabolic process nucleoside bisphosphate metabolic process purine nucleoside bisphosphate metabolic process ribonucleoside bisphosphate metabolic process oxoacid metabolic process carbohydrate derivative metabolic process organic acid metabolic process purine ribonucleoside bisphosphate metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process nucleoside phosphate metabolic process 3'-phosphoadenosine 5'-phosphosulfate metabolic process organonitrogen compound metabolic process nucleotide metabolic process purine-containing compound metabolic process organophosphate metabolic process purine ribonucleotide metabolic process developmental process fat cell differentiation regulation of biological process positive regulation of fat cell differentiation regulation of cellular process regulation of developmental process cellular developmental process positive regulation of biological process regulation of cell differentiation positive regulation of developmental process positive regulation of cell differentiation cell differentiation regulation of fat cell differentiation positive regulation of cellular process alcohol catabolic process primary alcohol catabolic process organic hydroxy compound metabolic process alcohol metabolic process ethanol metabolic process organic hydroxy compound catabolic process ethanol catabolic process small molecule catabolic process primary alcohol metabolic process	membrane-bounded organelle intracellular anatomical structure nuclear membrane membrane nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane cytoplasm membrane-bounded organelle intracellular anatomical structure nuclear membrane membrane nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000863	Sulfotransferase domain	Domain
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P49888	prostate cancer Liver Cirrhosis, Experimental liver disease alcoholic hepatitis cystic fibrosis drug-induced liver injury lung cancer ulcerative colitis asthma endometriosis malignant mesothelioma psoriasis uterine corpus leiomyoma cutaneous lupus erythematosus ischemia reperfusion injury

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	estrone sulfotransferase M-CSA #154	Estrogen sulfotransferase (EST) transfers the sulfate group from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the phenolic oxygen of estrogenic steroids. EST plays a role in many carcinogenic processes, with polymorphism implicated in genetic risk towards some cancers.	Defined by 3 residues: LYS:A-47HIS:A-107SER:A-137 \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 2.8.2.4 (PDB Primary Data) Search M-CSA Motif + EC 2.8.2.4

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